Dr.PGA Cosmetics What is gamma-PGA - 2013

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All about the most efficient natural skin moisturizer every developed gamma-PGA (polyglutamic Acid) or short γ-PGA. The unique functional cosmetic line Dr. PGA uses this moisturizer that is 10 time more powerful than Hyaluronic Acid. Lear more in this presentation...

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Dr.PGA Cosmetics What is gamma-PGA - 2013

  1. 1. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-Polyglutamic Acid (γ-PGA) & γ-Polygutamate Hydrogel What is γ-PGA?
  2. 2. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA 5 Dr. PGA products are the most powerful skin care moisturizing products every developed… What is γ-PGA?
  3. 3. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA 5 These trendy Dr.PGA Products contain a new moisturizing agent called: γ-PGA (gamma- PGA). The patented γ-PGA hydrogel used in these products, is the most powerful hydrating agent ever discovered! Most powerful moisturizing agent What is γ-PGA?
  4. 4. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA • γ-PGA is the worlds first Auto-Hydrating Agent….. • γ-PGA is not only Hydrating, but also Lightening…… • γ-PGA is more Hydrating than Hyaluronic Acid / more elastic than Collagen…. • γ-PGA is the best Hydrating Agent, for skin and hair care, ever discovered …. • γ-PGA can also be used as an anti-aging Skin Filler….. The most powerful moisturizing agent 6 What is γ-PGA?
  5. 5. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA is a wonderful and natural agent, ideal to enhance the effects of health care & skin care products. γ-PGA is integrated into the basic skin care product formulation. It dissolves excellently in water. Your can feel the difference on the soothing, refreshing & moisturizing effect immediately! FAST MOISTERIZING & REFRESHMENT! 7 γ-PGA IS ALL NATURAL!! What is γ-PGA?
  6. 6. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Originally the substance was discovered in the marine jellyfish. Which helps the jellyfish to store water in its fragile tissue and therefore dose not dehydrate in salty sea water thanks to γ-PGA. γ-PGA (Gamma-PGA) Dr.PGA – Power Moisturizing
  7. 7. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA A new development for best moisturizing results γ-PGA and polyglutamates are naturally occurred biopolymers with multifunctional ties. γ-PGA is biosythesized from L-glutamic acid with the microbe “Bacillus subtilis var natto” which has been one of the microbes used to make „Natto“ – fermented soybean, a traditional food and very popular in Japan for over 800 Years. 10 What is γ-PGA?
  8. 8. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA is edible, biodegradable, non-toxic to human body and good blood compatible. Its characteristic multi-carboxylic functional groups make it polyanionic bioploymer which has been highly proposed and recommended for use in several fields as…. 1. cosmetics moisturizer improving skin care quality, reducing wrinkle conditions and supporting natural moisturizing factor of the skin 2. health care agent for nutrition supplements, facilitating calcium absorption and improving osteoporosis conditions 11 What is γ-PGA?
  9. 9. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA 3. thickener for the food Industry as well as texture enhancer and as animal feed supplement facilitating mineral absorption 4. absorbent for water treatment for removing heavy metals and radionuclides 5. hydrogel for seed coating and the production of woman tampons due to high water absorbing character 6. hygiene product for baby diapers due to high water absorbent capacity 7. specialty application for biochips, membrane and LCD production due to biocompatibility 8. agriculture agent as natural biocide or inhibitor, it acts anti pathogenic 9. others for the production of biodegradable plastics 12
  10. 10. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Natto is the fermented soybean which contains higher vitamin B2,B6,B12,E,K2, -PGA and many other digestive enzymes. The sticky material of natto is -PGA. NATTO & γ-PGA What is γ-PGA?
  11. 11. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA fills up the los of moisture in the skin and has the ability to keep moisture longer in the skin. What is γ-PGA?
  12. 12. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA salt can easily dissolve into water and becomes ionized. (K+,Na+,NH4 +,Ca+2,Mg+2) • Polyanions • Polyelectrolyte • Macroions 8 What is γ-PGA?
  13. 13. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA – hydrogel γ-PGA powder Water After 3 to 4 minutes the water becomes a gel γ-PGA has the incredible capacity to bind water. Up to 5000 times it's own molecular weight What is γ-PGA?
  14. 14. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA – hydrogel structure Microscopic and 3D images of γ-PGA Microscope image 3D image What is γ-PGA?
  15. 15. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA is a powerful cosmetics moisturizer improving skin care quality, reducing wrinkle conditions and supporting natural moisturizing factor of the skin! A new development for best moisturizing results What is γ-PGA?
  16. 16. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA Helix Structure 15 What is γ-PGA?
  17. 17. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA -PGA is a homopolypeptide made of only glutamic acid in -peptide bond linkage with the degree of polymerization (n) from 1000 to 12´000 16 What is γ-PGA?
  18. 18. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Polyglutamic acid solutions have the abilities of skin miniaturization and of melanin inhibition. The molecular weight of polyglutamic acid can be reduced efficiently by HCl hydrolysis. The viscosity of low molecular weight of polyglutamic acid solutions are not affected by pH values. When polyglutamic acid is added to emulsion, the particle size of emulsion is reduced and the ability of skin moisturization of the emulsion increases. Polyglutamid acid can be used as an excellent ingredient for skin moisturizers. 17 What is γ-PGA?
  19. 19. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Long lasting effects of γ-PGA The material γ-PGA Hydrogel is with unique surpassing moisture holding capability, combining with functions of different molecules of γ-PGA, can develop longer time of one-way slow release action to thoroughly infiltrate encapsulated active ingredients into deep layer of skin. What is γ-PGA?
  20. 20. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA plays a role as a filler, being able to penetrate into 3 different levels of our facial skins due to its different molecule sizes. γ-PGA can create water channel beneath the skin:
  21. 21. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA That's why γ-PGA can quickly fill the gaps between skin cells, diminish the pores and re-firm your facial skin within a moment!. 10 What is γ-PGA?
  22. 22. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA is not only an hydrating ingredient for skin but also a good “ carrier “ for other ingredients! γ-PGA with abundant of negative charges is so good for binding with positively charged trace elements provide the optimal adhesion to the skin which is normally negatively charged. 11 What is γ-PGA?
  23. 23. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Dr.PGA Super Hydration for Skin & body 12 γ-PGA Hydrogel It is a proven fact that the moistur- izing capability of is 10 times more than that of Hyaluronic Acid!
  24. 24. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Fermented soybean = NATTO GUM = γ-PGA •International Nomenclature Cosmetic Ingredient (INCI) NATTO GUM •EINECS No. : 310-127-6 The European Inventory of Existing Commercial Substances (EINECS) •CAS No. : 9079-02-1 Chemical Abstracts Service Registry No. Function : film forming What is γ-PGA?
  25. 25. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Polyglutamic Acid Solution •International Nomenclature Cosmetic Ingredient (INCI) Polyglutamic acid •CTFA No.: 5788 The Cosmetic, Toiletry, and Fragrance Association (CTFA) •CAS No. : 26247-79-0 Chemical Abstracts Service Registry No. Function : film forming •CN-Code: 39139080 EU Combined Nomenclature (CN) code What is γ-PGA?
  26. 26. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA vs. Regular Peptides γ-PGA Regular Peptides Body Units Glutamic Acid 20 Amino Acids Photosensitivity Both in L&D-form Mostly in L-form Amide Linkage γ-peptide α-peptide R-group Super Hydrophilic Hydrophilic & Hydrophobic Bonding Molecules 10000 Less than 10000 Bio-degradable Slow Fast Bio-synthetic germ Few Many Essential to Body Non-essential Essential What is γ-PGA?
  27. 27. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Schematic representation of the cross-linked structure of a hydrogel including tetrafuncional (A) and multifunctional (B) cross-links, chain ends (C.D.), entanglements (E), loops (F) and unreacted polymer chains (G). The distance between two consecutive cross-links when expressed as molecular weight. Is the molecular weight between cross-links Mc . Upon swelling by a penetrant (•) the space between cross-links (H) is available for diffusion solute flow, etc… γ-PGA – hydrogel What is γ-PGA?
  28. 28. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA applied onto the skin, can enhance the Natural Moisturizing Factors ( NMF ) from deep inside the skin such as Pyrolidone Carboxylic Acid (PCA), Lactic Acid and Urocanic Acid, so that the skin will recover the natural rehydrating ability. This effect will never happen for example on Hyaluronic Acid (HA). γ-PGA truly enhances NMF Natural Moisturizing Factor
  29. 29. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA is known today as the most powerful moisturizer for skin care ever discovered. After using γ-PGA for a minimum of 28 days, it can positively influence and regulate the Natural Moisturizing Factor of the skin. It also has a special characteristic in supporting active agents of cosmetic products, as a carrier, to penetrate the skin more efficiently. Natural Moisturizing Factor / NMF of the skin γ-PGA truly enhances NMF
  30. 30. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA 、Hyaluronic Acid (HA)、Collagen stimulating effect on skin NMF 150 100 50 0 % 0 11 28 days PGA HA Collagen Note: Applied once daily
  31. 31. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Moisturizing effect Test - Comparison between γ-PGA、 Hyaluronic Acid (HA) and Collagen in stratum corneum layer of skin Collagen HA γ-PGA Moisturizing Effect
  32. 32. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Trans-Epidermal Water Loss – Test comparison between γ-PGA 、Hyaluronic Acid (HA) and Collagen 80 85 90 95 100 105 110 1 14 28 Days Collagen HA γ-PGA TEWL Test%
  33. 33. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Skin Elasticity Test - comparison between γ-PGA 、 Hyaluronic Acid (HA) and Collagen 80 85 90 95 100 105 110 115 1 14 28 Days Collagen HA γ-PGA % Skin Elasticity 27
  34. 34. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Skin Moisture comparison Skin Moisture An age related definciancy state (rough and dark) γ-PGA replenishes the skin‘s own moisture balance (Brighter, smoother, softer )
  35. 35. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA Hyarulonic Acid Collagen skin miniaturization water loss of skin elasticity extension NMF growth Conclusion Enhance skin moisture by functional film Cover skin with physical film Cover skin with physical film Skin Care Comparison between γ-PGA, Hyarolonic Acid and Collagen
  36. 36. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA Hyaluronic Acid Collagen Origin Vegetable (natto germ) Animal (chicken crown) Animal (pig or sheep) Structure Mono-peptide Bi-saccharide Tri-peptide Germ Resistance Elasticity NMF Growth Hydrophilicity strong fair weak pH-balance excellent good good Skin film smooth sticky sticky Skin Water Loss (TEWL) Conclusion Excellent Good Good Skin Care Comparison between γ-PGA, Hyaluronic Acid & Collagen
  37. 37. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA truly enhances NMF Test Results. Corneometry
  38. 38. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA applied to hair improves surface structure Before treatment with γ-PGA After 1 week of treatment with γ-PGA γ-PGA truly enhances NMF
  39. 39. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Nucleus contains vital bioinformation for intra & extra cellular communication Mitochondria (cross-section) Each cell disposes of several of these „power-stations“ Mitochondria Energy Reservoir Adenosin- triphosphate (ATP) ATP is a form to keep cellular energy Mitochondria of each skin cell is involved supporting NMF O2 ATP ADP A From the Blood CO2 Back to Blood Energy DNA H2O = Natural Moisterizing Factor / NMF 33
  40. 40. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA New research reveals - Our top layer of the skin, the stratum corneum, takes its oxygen straight from the air & surrounding. But only moist skin can efficiently absorb oxygen to supply the skin cells. Skin moisturizing is crucial. The skin surface gets its oxygen from the atmosphere, not the blood! Insufficient oxygen supply to the cells reduces the natural moisturizing ability of the skin significantly. Visual signs of dry and ageing skin appear O2 O2 O2 O2O2 O2 What is γ-PGA?
  41. 41. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Markus Stücker of the Ruhr-University in Bochum, Germany, and his dermatologist colleagues have found that air supplies the top 0.25 - 0.4 mm of the skin with oxygen. This is almost 10 times deeper than previous estimates. This zone includes the entire outermost layer of living cells - the epidermis - and some of the dermis below, which contains sweat glands and hair roots. R&D Background 35 What is γ-PGA?
  42. 42. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA The finding could change skin care specialists approach to skin conditions. Says David Harrison, who studies the use of oxygen by the skin at the University Hospital of North Durham, UK: "Everyone thought that atmospheric oxygen was unimportant, but a significant depth of the skin is supplied from the air and environment." This fact opens new aspects on using skin care products containing γ-PGA! R&D Background 36 What is γ-PGA?
  43. 43. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA The achievement on the development of γ-PGA received the 2003 national Biotechnology Gold Prize 37 R&D Background What is γ-PGA?
  44. 44. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA 2003.12 2003-423533 Biodegradable, High Water Absorbable PGA Hydrogel BY 3- Dimentional Cross-Linking and ITS Preparation Method 2003.12 200410004665.6 1-2004-00210 2003.12 092136155 2003.12 03258255.3 10/740,977 γ-PGA – global patent as brand new hydrating agent 38 What is γ-PGA?
  45. 45. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA • Visible signs of dry and aging skin are mainly due to reduced ability of the skin to produce and store moisture. Solution - γ-PGA is the worlds first Auto-Hydrating Agent and can support and regulate in-depth the natural moisturizing factor of skin cells. • Many are looking today for a natural and non-aggressive way to lighten skin. Solution - γ-PGA is not only a great Hydrating agent but also has excellent Skin Lightening qualities. Skin Care research offers different interesting aspects for the use and application of γ-PGA : 39 What is γ-PGA?
  46. 46. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA •Moist skin is able to absorb much more oxygen then dry skin. Solution - Super hydration of skin with γ-PGA. To ensure a long lasting hydration γ-PGA has the ability to support and store moister in the skin •Moist skin looks fresher and younger due to hydration and more efficient oxygen supply from the surface. •Solution: γ-PGA supports the skin to optimize oxygen supply to the skins cells on the surface (the stratum corneum) 40 What is γ-PGA?
  47. 47. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA •Hyaluronic Acid and collagen as cosmetic agents are animal based and for many cosmetic users out today. •Solution – The patented γ-PGA is plant based and more Hydrating than Hyaluronic Acid Hyaluronic Acid reduces, after longer application, the cells natural moisturizing factor of the skin. Additionally γ-PGA A provides more elasticity to the skin than Collagen. γ-PGA can therefore also be used as an effective anti- aging Skin Filler 41 What is γ-PGA?
  48. 48. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-PGA is today’s best choice for skin hydration. γ-PGA is the best & most powerful Hydrating Agent ever discovered! 42 What is γ-PGA?
  49. 49. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Then contact us: FIBD GmbH Wolleraustrasse 41a CH-8807 Freienbach Switzerland Email info@fibd.biz Web www.fibdbusiness.com Interested in this product line?
  50. 50. Dr.PGA - Super HydrationYENA TRADING COMPANY Dr.PGA - What is γ-PGA Thank you for your attention!

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