Klinefelter Syndrome

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Klinefelter syndrome, also known as the XXY condition, is a term used to describe males who have an extra X chromosome in most of their cells. Instead of having the usual XY chromosome pattern that most males have, these men have an XXY pattern.


Klinefelter syndrome is named after Dr. Henry Klinefelter, who first described a group of symptoms found in some men with the extra X chromosome.  Even though all men with Klinefelter syndrome have the extra X chromosome, not every XXY male has all of those symptoms.


Because not every male with an XXY pattern has all the symptoms of Klinefelter syndrome, it is common to use the term XXY male to describe these men, or XXY condition to describe the symptoms.  


Scientists believe the XXY condition is one of the most common chromosome abnormalities in humans.  About one of every 500 males has an extra X chromosome, but many don’t have any symptoms. 


National Institute of Child Health & Human Development:

Klinefelter Syndrome

  1. 1. http://www.fitango.com/categories.php?id=332Fitango EducationHealth TopicsKlinefelter Syndrome
  2. 2. 1OverviewKlinefelter syndrome, also known as the XXYcondition, is a term used to describe males whohave an extra X chromosome in most of their cells.Instead of having the usual XY chromosomepattern that most males have, these men have anXXY pattern.
  3. 3. 2OverviewKlinefelter syndrome is named after Dr. HenryKlinefelter, who first described a group ofsymptoms found in some men with the extra Xchromosome. Even though all men with Klinefeltersyndrome have the extra X chromosome, not everyXXY male has all of those symptoms.Because not every male with an XXY pattern has allthe symptoms of Klinefelter syndrome, it iscommon to use the term **XXY male**
  4. 4. 3Overviewto describe these men, or **XXY condition**to describe the symptoms.Scientists believe the XXY condition is one of themost common chromosome abnormalities inhumans. About one of every 500 males has anextra X chromosome, but many don’t have anysymptoms.
  5. 5. 4OverviewNational Institute of Child Health & HumanDevelopment:
  6. 6. 5SymptomsNot all males with the condition have the samesymptoms or to the same degree. Symptomsdepend on how many XXY cells a man has, howmuch testosterone is in his body, and his age whenthe condition is diagnosed.The XXY condition can affect three main areas ofdevelopment:
  7. 7. 6Symptoms**Physical development:**As babies, many XXY males have weak musclesand reduced strength. They may sit up, crawl, andwalk later than other infants. After about agefour, XXY males tend to be taller and may have lessmuscle control and coordination than other boystheir age.
  8. 8. 7Symptoms**Physical development:**As XXY males enter puberty, they often don’t makeas much testosterone as other boys. This can leadto a taller, less muscular body, less facial and bodyhair, and broader hips than other boys. As teens,XXY males may have larger breasts, weaker bones,and a lower energy level than other boys.
  9. 9. 8Symptoms**Physical development:**By adulthood, XXY males look similar to maleswithout the condition, although they are oftentaller. They are also more likely than other men tohave certain health problems, such as autoimmunedisorders, breast cancer, veindiseases, osteoporosis, and tooth decay.
  10. 10. 9Symptoms**Physical development:**XXY males can have normal sex lives, but theyusually make little or no sperm. Between 95percent and 99 percent of XXY males are infertilebecause their bodies don’t make a lot of sperm.**Language development: **
  11. 11. 10Symptoms**Physical development:**As boys, between 25 percent and 85 percent ofXXY males have some kind of languageproblem, such as learning to talk late, trouble usinglanguage to express thoughts and needs, problemsreading, and trouble processing what they hear.As adults, XXY males may have a harder time doingwork that involves reading and writing, but mosthold jobs and have successful careers.
  12. 12. 11Symptoms**Social development:**As babies, XXY males tend to be quiet andundemanding. As they get older, they are usuallyquieter, less self-confident, less active, and morehelpful and obedient than other boys.
  13. 13. 12Symptoms**Social development:**As teens, XXY males tend to be quiet and shy. Theymay struggle in school and sports, meaning theymay have more trouble “fitting in” with other kids.However, as adults, XXY males live lives similar tomen without the condition; they havefriends, families, and normal social relationships.
  14. 14. 13Symptoms**Social development:**National Institute of Child Health & HumanDevelopment:
  15. 15. 14TreatmentThe XXY chromosome pattern can not be changed.But, there are a variety of ways to treat thesymptoms of the XXY condition.
  16. 16. 15Treatment**Educational treatments**– As children, many XXY males qualify for specialservices to help them in school. Teachers can alsohelp by using certain methods in the classroom,such as breaking bigger tasks into small steps.
  17. 17. 16Treatment**Therapeutic options**– A variety of therapists, such asphysical, speech, occupational, behavioral, mentalhealth, and family therapists, can often helpreduce or eliminate some of the symptoms of theXXY condition, such as poor muscle tone, speechor language problems, or low self-confidence.
  18. 18. 17Treatment**Medical treatments**– Testosterone replacement therapy (TRT) cangreatly help XXY males get their testosterone levelsinto normal range. Having a more normaltestosterone level can help develop biggermuscles, deepen the voice, and grow facial andbody hair. TRT often starts when a boy reachespuberty. Some XXY males can also benefit fromfertility treatment to help them father children.
  19. 19. 18Treatment**Medical treatments**One of the most important factors for all types oftreatment is starting it as early in life as possible.National Institute of Child Health & HumanDevelopment:

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