2007
The current UK situation… <ul><li>Increasing herd size </li></ul><ul><li>Increasing 305 day yields </li></ul><ul><li>Worse...
Cell counts are increasing (NMR Data 2006)
Diagnosed Mastitis Pathogens (VIDA Data 2006)
Most farms have mixed infections… 2/3 of these included both a Gram -ve and a Gram +ve organism  That’s a total of  42%  o...
…  and of the farms with mixed infections …
Farmfile Data - Conclusions <ul><li>Most  farms have  multiple pathogens  that cause mastitis </li></ul><ul><li>Many farms...
Studies confirm the benefits of a longer dry period <ul><li>Milk yields were reduced for lactations following less than a ...
High risk of new dry cow infections during… <ul><li>Involution </li></ul><ul><ul><li>Intramammary pressure increases – wid...
<ul><li>Colostrogenesis </li></ul><ul><li>During the mid dry period the fully involuted udder is relatively resistant to b...
Cepravin delivers up to 10 weeks protection <ul><li>Cepravin remains active for at least 10 weeks against major mastitis p...
Cepravin Continues to Perform   EU sensitivity study 2000-2005 <ul><li>Major mastitis pathogens remain sensitive to cefalo...
Duration of activity…  <ul><li>Product LR provides up to 3 weeks cover for penicillin-sensitive organisms  (NOAH Data Shee...
Cepravin has been proven to speed up natural teat sealing (Williamson JH et al.) weeks 1  3  5  7  9  11  13
Do teat sealants seal? <ul><li>Recent trial, 232 cows ‘clean’ at drying off treated with internal sealant </li></ul><ul><l...
New infections post teat sealant 11 E. coli 81 All major pathogens 11 Strep. other 11 Strep. uberis 2 Strep. dysgalactiae ...
Teat sealants used alone <ul><li>New infections arise in teats that have been internally sealed </li></ul><ul><li>Gram +ve...
Cepravin delivers broad-spectrum cover <ul><li>Major Gram +ve pathogens </li></ul><ul><ul><li>S. aureus </li></ul></ul><ul...
Cepravin– the only dry cow tube licensed to reduce cell counts (Cepravin data sheet)
Summary: <ul><li>Cepravin DC  provides </li></ul><ul><ul><li>Up to 10 weeks protection </li></ul></ul><ul><ul><li>Broad sp...
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Cepravin 2007 q2 - vet presentation MSD Salud Animal Salud Lechera

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MSD Salud Animal Salud Lechera

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  • Contagious not as important, now environmental. E.coli is topical, but doesn’t have the impact of S.uberis on whole farm SCC….se next slides
  • Cepravin 2007 q2 - vet presentation MSD Salud Animal Salud Lechera

    1. 1. 2007
    2. 2. The current UK situation… <ul><li>Increasing herd size </li></ul><ul><li>Increasing 305 day yields </li></ul><ul><li>Worsening cell counts </li></ul><ul><li>Longer calving intervals </li></ul><ul><li>Increasing average age at first </li></ul><ul><li>calving </li></ul>(NMR Data 2006)
    3. 3. Cell counts are increasing (NMR Data 2006)
    4. 4. Diagnosed Mastitis Pathogens (VIDA Data 2006)
    5. 5. Most farms have mixed infections… 2/3 of these included both a Gram -ve and a Gram +ve organism That’s a total of 42% of all herds! (Farmfile Data 2004)
    6. 6. … and of the farms with mixed infections …
    7. 7. Farmfile Data - Conclusions <ul><li>Most farms have multiple pathogens that cause mastitis </li></ul><ul><li>Many farms have BOTH Gram positive and Gram negative pathogens </li></ul><ul><li>These farms require broad spectrum dry cow therapy </li></ul>
    8. 8. Studies confirm the benefits of a longer dry period <ul><li>Milk yields were reduced for lactations following less than a 60 day dry period </li></ul><ul><li>(Makuza & McDaniel) </li></ul><ul><li>Studies where half udders were subjected to 30 or 70 day dry periods showed that </li></ul><ul><ul><li>over the first 100 days of lactation 70 day dry periods produced 23% more milk than 30 day dry periods (Gulay et. al.) </li></ul></ul>
    9. 9. High risk of new dry cow infections during… <ul><li>Involution </li></ul><ul><ul><li>Intramammary pressure increases – widening of streak canal and teat orifice </li></ul></ul><ul><ul><li>Physical flushing out of bacteria stops </li></ul></ul><ul><ul><li>Teat hygiene measures cease </li></ul></ul><ul><ul><li>Milk fat and debris impair leucocyte function </li></ul></ul>
    10. 10. <ul><li>Colostrogenesis </li></ul><ul><li>During the mid dry period the fully involuted udder is relatively resistant to bacterial infection. However, many of the resistance mechanisms are reversed during colostrogenesis. </li></ul><ul><ul><li>Colostrum production increases intramammary pressure </li></ul></ul><ul><ul><li>Leucocyte concentration falls </li></ul></ul><ul><ul><li>The levels of natural bacterial inhibitors, such as lactoferrin, are reduced </li></ul></ul>High risk of new udder infections during… Therefore, antibiotic cover is required throughout the dry period
    11. 11. Cepravin delivers up to 10 weeks protection <ul><li>Cepravin remains active for at least 10 weeks against major mastitis pathogens including: </li></ul><ul><ul><li>S. aureus </li></ul></ul><ul><ul><li>S. uberis </li></ul></ul><ul><ul><li>S. dysgalactiae </li></ul></ul><ul><ul><li>A. pyogenes </li></ul></ul><ul><li>Up to 5 weeks cover against E. coli </li></ul>
    12. 12. Cepravin Continues to Perform EU sensitivity study 2000-2005 <ul><li>Major mastitis pathogens remain sensitive to cefalonium at MIC 90 levels which are achieved in the udder </li></ul><ul><li>Confirms 10 weeks activity vs </li></ul><ul><ul><li>S. uberis </li></ul></ul><ul><ul><li>S. aureus </li></ul></ul><ul><ul><li>S. dysgalactiae </li></ul></ul><ul><ul><li>A. pyogenes </li></ul></ul><ul><li>All tested strains of E.coli sensitive to </li></ul><ul><li>cefalonium </li></ul>
    13. 13. Duration of activity… <ul><li>Product LR provides up to 3 weeks cover for penicillin-sensitive organisms (NOAH Data Sheet) </li></ul><ul><li>Product CG provides up to 5 weeks cover </li></ul><ul><li>(Thomas et. al.) </li></ul><ul><li>Product OE has no activity against Gram –ve organisms (NOAH Data Sheet) </li></ul><ul><li>Cepravin provides up to 10 weeks cover against the most commonly diagnosed Gram +ve and Gram –ve pathogens </li></ul>
    14. 14. Cepravin has been proven to speed up natural teat sealing (Williamson JH et al.) weeks 1 3 5 7 9 11 13
    15. 15. Do teat sealants seal? <ul><li>Recent trial, 232 cows ‘clean’ at drying off treated with internal sealant </li></ul><ul><li>81 new infections with major mastitis pathogens isolated immediately post-calving </li></ul><ul><li>Gram +ve and Gram -ve bacteria isolated </li></ul><ul><ul><li>14% of these infections were E.coli </li></ul></ul>(Huxley et al, 2002)
    16. 16. New infections post teat sealant 11 E. coli 81 All major pathogens 11 Strep. other 11 Strep. uberis 2 Strep. dysgalactiae 9 Staph. aureus New infections Pathogen
    17. 17. Teat sealants used alone <ul><li>New infections arise in teats that have been internally sealed </li></ul><ul><li>Gram +ve and Gram -ve infections occur </li></ul><ul><li>If considering using antibiotic DCT as well </li></ul><ul><ul><li>Effective cover against Gram +ve and </li></ul></ul><ul><ul><li>Gram –ve bacteria required </li></ul></ul><ul><ul><li>Ensure covers entire dry period </li></ul></ul>
    18. 18. Cepravin delivers broad-spectrum cover <ul><li>Major Gram +ve pathogens </li></ul><ul><ul><li>S. aureus </li></ul></ul><ul><ul><li>S. uberis </li></ul></ul><ul><ul><li>S. dysgalactiae </li></ul></ul><ul><ul><li>A. pyogenes </li></ul></ul><ul><li>Gram –ve pathogens, including E. coli </li></ul>
    19. 19. Cepravin– the only dry cow tube licensed to reduce cell counts (Cepravin data sheet)
    20. 20. Summary: <ul><li>Cepravin DC provides </li></ul><ul><ul><li>Up to 10 weeks protection </li></ul></ul><ul><ul><li>Broad spectrum cover including E. coli </li></ul></ul><ul><ul><li>Earlier teat sealing </li></ul></ul><ul><ul><li>Proven ability to lower SCC </li></ul></ul><ul><li>Proven activity against A. pyogenes , cause of Summer Mastitis </li></ul><ul><li>43% of dry cow antibiotic treatments are Cepravin DC </li></ul>

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