Goldman Sachs
Global Healthcare Conference
                Martin Mackay
  President, Global Research & Development




  ...
Forward-Looking Statements And
Non-GAAP Financial Information


  Discussions at this meeting will include forward-looking...
Our Path Forward


     Maximize Revenues
   from Existing, New and
      Diverse Sources
                                ...
Our Path Forward:
Strategies For Growth
                                    US Lipitor                   Post
            ...
Optimizing The Patent Protected Portfolio


                        Pipeline as of Feb 28, 2008



                       ...
Aggressive Goal To Rebuild Our
Phase 3 Portfolio


  Total of 15–20 Phase 3 starts 2008–2009


  Phase 3 total programs gr...
Today’s Phase 3 Portfolio



               axitinib – Pancreatic Cancer       PD-332334 – GAD

               apixaban – ...
Projected 15–20 Phase 3 Starts 2008–2009



               CP-751871          PF-885706 – GERD           PF-868554    PF-7...
Pfizer Disease Area Priorities

                    Invest to Win

      First or       High Market                High
  ...
Recent Oncology Phase 3 Starts

             Phase 3 Starts Since ASCO 2007
              Sutent           First line CRC
...
Potential New Indications Expected
To Drive Value




                                                       Colorectal


...
Pfizer Oncology Clinical Portfolio
           TSP-1
                                                                      ...
Axitinib Phase 3                                                            First or      High Market   High Unmet
       ...
CP-751871:                                                                    First or      High Market        High Unmet
...
Recent Oncology Licensing And Acquisitions


   Company/Compound                     Value to Pfizer Portfolio

          ...
First or      High Market   High Unmet
CP-690550:                                                        Best in Class    ...
PF-4383119 (RN-624):                          First or      High Market   High Unmet
                                     ...
PF-4383119:
Osteoarthritis Knee Pain

  Single IV Infusion: Mean Change from Baseline (mm) Over 8 Weeks

                 ...
86 Biotherapeutics In The Pipeline


     Research             Development                Marketed


      60             ...
Rebuilding The Phase 3 Portfolio

               Number of Phase 3 Programs

                                             ...
Building Momentum


     Sutent, Champix,      Approved for GIST and RCC, Smoking Cessation, PAH (Japan)
         sildenaf...
Goldman Sachs
Global Healthcare Conference
                Martin Mackay
  President, Global Research & Development




  ...
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Pfizer Invites Public to View and Listen to Webcast of Pfizer Participation at Healthcare Conference

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Pfizer Invites Public to View and Listen to Webcast of Pfizer Participation at Healthcare Conference

  1. 1. Goldman Sachs Global Healthcare Conference Martin Mackay President, Global Research & Development June 11, 2008
  2. 2. Forward-Looking Statements And Non-GAAP Financial Information Discussions at this meeting will include forward-looking statements. Actual results could differ materially from those projected in the forward-looking statements. The factors that could cause actual results to differ are discussed in Pfizer’s 2007 Annual Report on Form 10-K and in our reports on Form 10-Q and Form 8-K. Also, discussions during this meeting may include certain financial measures that were not prepared in accordance with generally accepted accounting principles. Reconciliations of those non-GAAP financial measures to the most directly comparable GAAP financial measures can be found in Pfizer’s Current Report on Form 8-K dated April 17, 2008. These reports are available on our website at www.pfizer.com in the “Investors—SEC Filings” section.
  3. 3. Our Path Forward Maximize Revenues from Existing, New and Diverse Sources Take Advantage of Size, Scale of Pfizer Establish a Lower, More Operate with Agility, Flexible Cost Base Speed, Focus of an Entrepreneurial Organization Innovate Our Business Model Drive Greater Total Shareholder Return
  4. 4. Our Path Forward: Strategies For Growth US Lipitor Post Today LOE Lipitor Optimize the Patent-Protected Portfolio Maximize the Value of New and Inline Products Advance Compounds in the Pipeline Maximize Capitalize on Established Products Revenues Sustainable TSR Growth Grow in Emerging Markets Revenue growth Invest in Complementary Businesses EPS Aggressively Manage Costs growth Flexible Cost Create More Flexible Operating Model Base Continuous Improvement in Processes Innovate Our Business Model
  5. 5. Optimizing The Patent Protected Portfolio Pipeline as of Feb 28, 2008 Approved Selzentry More than 300 Lyrica for Phase 1 Phase 2 Phase 3 In Reg. Discovery Fibromyalgia 47 37 16 2 Projects fesoterodine (EU) Accelerating Pipeline with sharpened focus on key disease areas Strong flow of medicines expected to progress from Phase 2 to Phase 3
  6. 6. Aggressive Goal To Rebuild Our Phase 3 Portfolio Total of 15–20 Phase 3 starts 2008–2009 Phase 3 total programs grow to 24–28 by December 2009 15–20 regulatory submissions between 2010–2012
  7. 7. Today’s Phase 3 Portfolio axitinib – Pancreatic Cancer PD-332334 – GAD apixaban – VTE Prevention S,S-reboxetine – Fibromyalgia NMEs CP-945598 – Obesity Zithromax/chloroquine – Malaria CP-751871 - Lung Cancer PF-1228305 (Thelin) – PAH New apixaban – Indications Atrial Fibrillation / apixaban – VTE Treatment
  8. 8. Projected 15–20 Phase 3 Starts 2008–2009 CP-751871 PF-885706 – GERD PF-868554 PF-734200 – Lung Cancer – HCV – Diabetes PF-299804 – Cancer PF-4383119 PF-4194471 PF-4522625 PH-797804 – RA – OA Pain – HIV – Seasonal Flu NMEs IV sulopenem/Oral PD-200390 CP-690550 UK-453061 sulopenem pro-drug – Insomnia – RA – HIV – Bacterial Infections UK-369003 – LUTS apixaban – VTE PF-4383119 treatment – Chronic Pain apixaban – ACS New S,S-reboxetine – DPN axitinib – RCC & Indications sildenafil citrate IV Lung
  9. 9. Pfizer Disease Area Priorities Invest to Win First or High Market High Best in Class Growth Unmet Need Oncology Pain Immunology/Inflammation Diabetes/Obesity Alzheimer’s Disease Schizophrenia
  10. 10. Recent Oncology Phase 3 Starts Phase 3 Starts Since ASCO 2007 Sutent First line CRC Sutent Second line NSCLC Sutent Adjuvant RCC Axitinib Pancreatic cancer CP-751871 First line NSCLC CP-751871 Refractory NSCLC Phase 3 Trials Expected to be Initiated in 2008 Sutent First line HCC Sutent Second line mHRPC Axitinib Second line mRCC Axitinib First line NSCLC CP-751871 First line NSCLC
  11. 11. Potential New Indications Expected To Drive Value Colorectal es nu ve Non Small Cell Lung Re Hepatocellular Carcinoma Breast Renal Cell Carcinoma & Gastrointestinal Stromal Tumor Time
  12. 12. Pfizer Oncology Clinical Portfolio TSP-1 Platform Key (CVX-045)* Anti-Angiogenesis Ang-2 Ant (CVX-060)* Transitions Since ASCO 2007 Signal Transduction ALK1 mAb (PF-3446962) Immunotherapy sVEGFR (PF-337,210) Cytotoxic/ Potentiators mRTK P-Cad mAb (SU-14,813) (PF-3, 732,010) Pan-ErbB FAK Sutent® (PF-00299804) (PF-562,271) Sutent® EGFRvlll C-Met Aromasin® (CDX-110) (PF-2,341,066) Axitinib (AG-013,736) Tremelimumab C-Met BU Camptosar® (CP-675,206) (PF-4217903) IGF-1R mAb TLR9 (CP-751,871) Hsp90 Ellence ® (PF-3,512,676) (SNX 5422) CD40 mAb PARP (CP-870,893) AG-14,699 *Pfizer Biotherapeutics and Bioinnovation Center CDK 4/6 (PD-332991) CHK1 (PF-477,736) AUR2 (PF-3,814,735 13 6 3 4 Phase I Phase 2 Phase 3 Approved
  13. 13. Axitinib Phase 3 First or High Market High Unmet Best in Class Growth Need In 1st Line NSCLC Axitinib demonstrates activity as a single-agent in refractory NSCLC patients (14.6 months median survival) Axitinib demonstrates good combinability with chemotherapy Overall Survival Phase 3 Study Design 1.0 R R A A 0.8 Axitinib + N N Gem/Cis Survival Probability D D O 0.6 Stage IIIb or O M IV NSCLC M II n=1000 0.4 Z Z A A T Placebo + T 0.2 Median Overall Survival: 14.6 months II Gem/Cis (95% CI: 107, undefined) O O N 0.0 N 0 5 10 15 20 Establish Efficacy of Axitinib Survival Time (Months) in 1st Line NSCLC Schiller et al., ASCO 2007
  14. 14. CP-751871: First or High Market High Unmet Best in Class Growth Need Phase 2 NSCLC Activity Carboplatin/Paclitaxel Treatment-naïve Stage IIIB/IV NSCLC Patients Carboplatin/Paclitaxel + CP-751,871 Overall Population Dose (mg/kg) 0 10 20 Sample size (n) 50 46 53 100 Dose: Median PFS (months) 4.3 3.6 5.0 0 80 10 p = 0.017 20 60 Population 20 mg/kg demonstrated 40 significantly improved PFS 20 Highest ORR in squamous histologies linked to highest PFS 0 (5.6mo @ 20mg/kg) 0 50 100 150 200 250 300 350 Time (Days) Karp et al ASCO 2008
  15. 15. Recent Oncology Licensing And Acquisitions Company/Compound Value to Pfizer Portfolio Novel vaccine in Phase 2b/3 for GBM Avant – license CDX-110 (EGFRvIII vaccine) High unmet medical need Serenex – acquisition Phase I, novel mechanism SNX-5422 (Hsp90 inhibitor) Complementary to portfolio Two Phase I agents CovX – acquisition CVX 045 (thrombospondin), Novel anti-angiogenesis mechanisms CVX 060 (angiopoietin) Expands vaccine development capability Coley – acquisition Vaccine platform, TLR-7 and TLR-9 Strengthens immuno-oncology portfolio programs
  16. 16. First or High Market High Unmet CP-690550: Best in Class Growth Need JAK-3 Inhibitor RA Phase 2a Response Rate 100 80 60 40 20 0 0 2 4 6 Weeks Phase 2b dose ranging in rheumatoid Placebo 5 mg 15 mg 30 mg arthritis ongoing – anticipate Kremer JM et al, ACR 2006 presentation at ACR 2008 Simultaneous Development Programs in Psoriasis, Transplant Rejection, Rheumatoid Arthritis and Crohn’s Disease
  17. 17. PF-4383119 (RN-624): First or High Market High Unmet Best in Class Growth Need Nerve Growth Factor Inhibitor Heavy Projected 1st Biotherapeutic for Pain Chain Blocks Nerve Growth Factor (NGF) Humanized monoclonal antibody NGF Efficacy demonstrated in Phase 2 osteoarthritis (OA) pain study Favorable safety profile to date >600 patients treated Light Chain
  18. 18. PF-4383119: Osteoarthritis Knee Pain Single IV Infusion: Mean Change from Baseline (mm) Over 8 Weeks Panel 1 Panel 2 Baseline Pain = 43–46 mm Baseline Pain = 54–60 mm n=12 n=6 n=6 n=6 n=26 n=27 n=26 0 -5 -10 -15 -20 -25 * * -30 * * -35 Placebo 0.1 mg/kg 0.3 mg/kg 1.0 mg/kg Encouraging Phase 1/2 Efficacy and Safety Data * p<0.05 vs placebo
  19. 19. 86 Biotherapeutics In The Pipeline Research Development Marketed 60 26 5 $1.4 B 2007 Diverse Portfolio Revenues 8 TAs (dalteparin sodium injection) (interferon beta-1a) 6 Modalities 53 MAbs 8 Vaccines (pegvisomant for injection)
  20. 20. Rebuilding The Phase 3 Portfolio Number of Phase 3 Programs 24–28 22–24 16 Mar '08 Mar '09 Dec '09 Projected Projected NMEs New Indications
  21. 21. Building Momentum Sutent, Champix, Approved for GIST and RCC, Smoking Cessation, PAH (Japan) sildenafil Zithromac SR, Xalacom, Submitted for Bacterial Infections, Glaucoma, HIV Treatment Experienced Patients (Japan) Maraviroc Lyrica, Fablyn Submitted for Fibromyalgia, Osteoporosis Treatment (Europe) CP-751871, Geodon Adj Depression, apixaban (VTE treatment) Advanced to Phase 3 Sutent CRC, axitinib and Neurontin Peds (Japan) Potential New Oncology Sutent and axitinib Indications Avant, Encysive, Serenex, CovX Business Development 3 POCs, 13 FIPs, 8 FIHs Early Portfolio
  22. 22. Goldman Sachs Global Healthcare Conference Martin Mackay President, Global Research & Development June 11, 2008

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