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Delirium in the ICU ,[object Object],Dr. Andrew Ferguson MEd FRCA FCARCSI DIBICM FCCP
[object Object],Gallway MB (1838). Nature and treatment of delirium. Lond Med Gazette 1: 46–49.
Overview ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What is Delirium? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
How is Delirium Categorised? Hyperactive Hypoactive Mixed 1.6% of cases,  “ ICU psychosis ”, agitation, restlessness, “picking”, emotional lability 54.1% % of cases 43.5% of cases,  “ encephalopathy ”, often unrecognised, withdrawal, flat affect, apathy, lethargy, decreased responsiveness, may be misdiagnosed as depression
Why does delirium matter? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],* Ely et al, Intensive Care Med 2001; 27: 1892-1900 ** Ely et al, JAMA 2004; 291: 1753-62 *** Milbrandt et al, CCM 2004; 32: 955-62
 
Why does delirium happen? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Why does delirium happen? Serotonin Acetylcholine Dopamine Opioids & benzo’s 2 o  brain infection Decreased cerebral metabolism 1 o  intracranial disease Systemic disease Hypoxia Metabolic derangement Withdrawal syndromes Toxins
Risk factors for delirium Van Rompaey Intensive and Critical Care Nursing 2008;  24: 98—107
Age Severity Benzo’s Pun & Ely, Chest 2007; 132: 624–636 Pandharipande et al, Anesthesiology 2006; 104: 21-26
DELIRIUM(S) - causes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
I WATCH DEATH ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnosis & monitoring Level  of consciousness Content  of consciousness
Diagnosis & monitoring ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
ICDSC
CAM-ICU
Treating delirium ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treating delirium -  haloperidol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Girard & Ely, Handbook of Clinical Neurology 2008; 90: chapter 3
Treating delirium – atypical antipsychotics ,[object Object],[object Object],[object Object],[object Object],Girard & Ely , Handbook of Clinical Neurology 2008; 90: chapter 3 Skrobik YK, Bergeron N, Dumont M et al . (2004). Olanzapine vs haloperidol: treating delirium in a critical care set- ting. Intensive Care Med 30: 444–449.107: 341–351. Han CS, Kim YK  (2004). A double-blind trial of risperidone and haloperidol for the treatment of delirium. Psychosomatics 45: 297–301  Breitbart W,  Marotta R, Platt M  et al. (1996). A double- blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am J Psychiatry 153: 231–237.
Internet Resources ,[object Object]

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Preventing and Treating Delirium in the ICU

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  • 5. How is Delirium Categorised? Hyperactive Hypoactive Mixed 1.6% of cases, “ ICU psychosis ”, agitation, restlessness, “picking”, emotional lability 54.1% % of cases 43.5% of cases, “ encephalopathy ”, often unrecognised, withdrawal, flat affect, apathy, lethargy, decreased responsiveness, may be misdiagnosed as depression
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  • 9. Why does delirium happen? Serotonin Acetylcholine Dopamine Opioids & benzo’s 2 o brain infection Decreased cerebral metabolism 1 o intracranial disease Systemic disease Hypoxia Metabolic derangement Withdrawal syndromes Toxins
  • 10. Risk factors for delirium Van Rompaey Intensive and Critical Care Nursing 2008; 24: 98—107
  • 11. Age Severity Benzo’s Pun & Ely, Chest 2007; 132: 624–636 Pandharipande et al, Anesthesiology 2006; 104: 21-26
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  • 14. Diagnosis & monitoring Level of consciousness Content of consciousness
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  • 18. ICDSC
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