11.12 (dr. husun bano) membrane potential part i

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11.12 (dr. husun bano) membrane potential part i

  1. 1. MEMBRANE POTENTIAL(Part-1) Husan Bano Assistant Professor Deptt. Physiology SMC,DUHS
  2. 2. BY THE END OF THIS LECTURE YOU SHOULD BE ABLE TO : <ul><li>COMPARE THE CHRACTERSTIC OF EXCITABLE AND NON EXCITABLE CELLS </li></ul><ul><li>DEFINE THE RESTING MEMBRENE POTENTIAL </li></ul><ul><li>EXPLAIN THE GENERATION AND MAINTAINANCE OF RESTING MEMBRANE POTENTIAL. </li></ul><ul><li> </li></ul>
  3. 3. TYPES OF CELLS <ul><li>EXCITABLE CELLS </li></ul><ul><li>NON-EXCITABLE CELLS </li></ul>
  4. 4. EXCITABLE CELLS <ul><li>EXSIST HIGH ELECTRICAL POTENTIAL DIFFERENCE ACROSS THE MEMBRANE </li></ul><ul><li>GENERATE ACTION POTENTIAL </li></ul><ul><li>PROPAGATE ACTION POTENTIAL </li></ul><ul><li>e.g. Nerve & Muscle </li></ul>
  5. 5. EXCITABLE CELL
  6. 6. NON-EXCITABLE CELLS <ul><li>LOW POTENTIAL DIFFERENCE ACROSS THE MEMBERANE. </li></ul><ul><li>DO NOT GENERATE AND PROPAGATE ACTION POTENTIAL. </li></ul><ul><li>e.g. Glandular cells, Macrophages, Blood cells etc </li></ul>
  7. 7. RESTING STATE
  8. 8. GENERATION OF RESTING MEMBERANE POTENTIAL <ul><li>IONIC DESTRIBUTION OF ICF AND ECF </li></ul>3-5 103-105 Cl - (mEq/L) 200 ABSENT PROTEIN(-) 140 3-5 K + (mEq/L) 10 140 Na + (mEq/L) Intracellular Fluid* Extracellular Fluid Substance and Units
  9. 9. ION FLUXES IN RESTING STATE <ul><li>Na + 142meq/L PO4-- 4meq/L </li></ul><ul><li>K + 5 -10 P- absent </li></ul><ul><li>Cl - 103-105 ECF </li></ul><ul><li>------------------------------------------------------------- </li></ul><ul><li>Na + 10meq/L PO 4 - - 75 m.eq/L ICF </li></ul><ul><li>K + 142 P - 200 mg% </li></ul><ul><li>Cl – 3-5 </li></ul><ul><li>------------------------------------------------------------ </li></ul>
  10. 10. SODIUM-POTASSIUM PUMP
  11. 11. SODIUM-POTASSIUM PUMP
  12. 12. ION FLUXES
  13. 13. REASONS OF RMP <ul><li>ACTIVE TRANSPORT OF SODIUM IONS FROM ICF TO ECF. </li></ul><ul><li>PASSIVE TRANSPORT OF POTASSIUM IONS FROM ICF TO ECF. </li></ul><ul><li>PASSIVE TRANSPORT OF CHLORIDE IONS FROM ECF TOICF. </li></ul>
  14. 14. ~~~ Cont. <ul><li>4. PRESENCE OF NEGATIVELY CHARGED PROTEIN IONS AND PHOSPHATE IONS IN ICF </li></ul>
  15. 15. RMP OF DIFFERENT EXCITABLE CELL <ul><li>Due to the combine reason. the RMP of an excitable cell ranges from -60mv to -90 mv </li></ul><ul><li>eg. </li></ul><ul><li>-60 mv ( Smooth muscle) </li></ul><ul><li>-90 mv ( Skeletal muscle) </li></ul><ul><li>-90 mv ( Nerve fiber ) </li></ul><ul><li>-85mv to -90mv (Cardiac muscle) </li></ul>
  16. 16. DEFINATION OF RMP <ul><li>The potential difference accrose the membrane in resting condition is called resting membrane potential (RMP). </li></ul>
  17. 17. <ul><li>THE END </li></ul>THANKS

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