4. DEFINITION OF PORTAL HYPERTENSION.
Portal hypertension occurs when the pressure in the portal venous
system is raised. This may happen as a result of chronic liver
disease, particularly in the cirrhotic stage, when the nodular and
fibrosed nature of the parenchyma impedes the flow of blood into
6. • The portal venous system extends from
the intestinal capillaries to the hepatic
sinusoids. This venous system carries the
blood from the abdominal gastrointestinal
tract, the pancreas, gallbladder, and
spleen back to the heart (coursing
through the liver).
• The portal vein supplies 70% of the blood
flow to the liver, but only 40% of the liver
oxygen supply. The remainder of the
blood comes from the hepatic artery,
and blood from both of these vessels
mixes in the sinusoids.
• The liver receives a tremendous volume of
blood, on the order of 1.5 liters per
Normal portal vein pressures range from 5–10 mm Hg.
Portal hypertension is present when the portal vein pressure exceeds 12 mmHg.
1) Prehepatic or Infrahepatic Causes.
2) Intrahepatic or Hepatic Causes .
3) Posthepatic or Suprahepatic Causes.
8. 1. PREHEPATIC OR INFRAHEPATIC CAUSES
i. Congenital Atresia Or Stenosis.
ii. Thrombosis Of Portal Vein.
iii. Thrombosis Of Splenic Vein.
iv. Extrinsic compression (e.g , tumor). Portal Vein
9. 2. INTRAHEPATIC OR HEPATIC CAUSES .
i. liver cirrhosis
ii. hepatic fibrosis (e.g. due to Wilson's
iii. less commonly noncirrhotic causes
such as schistosomiasis, massive
fatty change and diffuse
10. 3. POSTHEPATIC OR SUPRAHEPATIC CAUSES.
i. Budd-chiari Syndrome ( Hepatic
Vein Thrombosis )
ii. IVC thrombosis.
iii. Cardiac Disease:
a. Constrictive Pericarditis.
b. Valvuar Heart Disease.
c. Right Heart Failure.
11. • Ascites (free fluid in the peritoneal
cavity) & Cirrhotic liver
Transabdominal ultrasound shows loops of
small bowel with thickened walls floating
within ascitic fluid due to portal hypertension
Cirrhotic right hepatic lobe
with the surrounding ascites.
12. • Splenomegaly.
Splenomegaly in portal hypertension. The
inferior splenic margin is blunted, descending
below and medial to the left kidney.
Varices at the splenic hilum
in portal hypertension.
13. • Dilated portal veins
The Normal Portal Vein is < 1.3 cm,
> 20% change in caliber with respiration
14. • Ligamentum Teres
Para-umbilical channel running along the ligamentum teres to the anterior abdominal
wall in a patient with end-stage chronic liver disease and portal hypertension.
15. • Porto System Collaterals
Splenic Vein Occlusion
Longitudinal color Doppler ultrasound shows
an umbilical vein collateral extending
anteriorly from left portal vein branch
17. • Portal vein thrombosis
A, Longitudinal view ofthe main portal
vein (arrow) shows hypoechoic
thrombus throughout the venous
B, Transverse view ofthe left portal vein
shows focal isoechoic thrombus (arrow)
C, Longitudinal view of the main portal
vein shows focal hyperechoic thrombus
(arrows) within the lumen.
D, Transverse view of the main portal
vein shows a large hyperechoic
thrombus (arrow) near the splenic vein
Portal vein thrombosis in different patients.
18. • Hepatofugal (reversed) portal flow
Reversed PV flow in portal hypertension. Note the increased velocity of hepatic arterial flow indicated.