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Essential hypertension

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Essential hypertension

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Essential hypertension

  1. 1. OPTOM FASLU MUHAMMED .
  2. 2. What is Hypertension Hypertension is also referred to as high blood pressure or high BP in common terms It is a medical condition in which the arterial blood pressure is elevated. It is termed as silent killer – Patients asymptomatic - leads to fatal complications
  3. 3. Definition Greater than 140 mm hg of systolic blood pressure and or more than 90 mm hg of diastolic blood pressure at least on 2 of 3 occasions while measuring the pressure.
  4. 4. 1. How to measure blood pressure?
  5. 5. Nokolai Korotkoff, 1905 Ascultatory method of blood pressure measurement
  6. 6. How to measure Blood pressure??? Always measure B.P when the patient is completely relaxed. The instrument used is mercury sphygmomanometer . The cuff of the apparatus should cover up to three – fourth of his arm.
  7. 7. How to measure Blood pressure??? The tubings must be parallel to arteries of the arm. You must then inflate it until there is radial pulse depression. Then deflate and measure the value. The sound as korotkoff sound Details in the video link and audio link http://www.youtube.com/watch?v=u6saTO8_o2g&feature=related http://www.thinklabsmedical.com/stethoscope_community/Sound_Library
  8. 8. Terms What is Systolic blood pressure- upper limit of the pressure at which korotko’s sounds start appearing ---state of contraction in heart. Diastolic blood pressure is the lower limit of sounds heard - state of relaxation in peripheral blood vessels.
  9. 9. Normative values Systolic-90 mm hg – 120 mm hg. Diastolic-60 mm hg -80 mm hg.
  10. 10. JNC classification Systolic diastolic interpretation Less than 120 mm Hg Less than 80 mm Hg Normal 120 to 139 80 to 89 Pre hypertensive 140 to 159 90 to 99 Stage 1 Hypertension More than or equal to 160 More than or equal to 100 Stage 2 Hypertension > 220 > 120 Hypertensive emergency Source: Joint national committee on cardiovascular diseases 2003
  11. 11. Nearly 1 in 3 adults (31%) in the US has hypertension Fields LE et al. Hypertension. 2004;44:398-404. Hypertension: How Big Is the Problem? At Least 65 Million Americans Require Treatment for Hypertension
  12. 12. Magnitude of problem in India Prevalence 1 in 3 in urban population among 40 yrs or more More than 50% among persons aged 65 or more India is the capital of Diabetes Mellitus and the associated HT is > 60% The prevalence increasing with years
  13. 13. Types of Hypertension The most common cause for Hypertension is idiopathic and hence if the cause is not known it is called as primary or essential Hypertension--90% If it is secondary to other diseases -it is called as secondary hypertension.-10%
  14. 14. Pathophysiology The main reason is vasoconstriction which occurs due to sympathetic over-activity An overactive renin – angiotensin system leads to vasoconstriction and retention of sodium and water.
  15. 15. ESSENTIAL HTN Benign(chronic) Rise in B.P is slight to moderate Complications: heart failure, cerebrovascular accident or MI Risk factors
  16. 16. Malignant (accelerated) Rapid & aggressive acceleration Diastolic pressure in excess of 120 mmHg Eg: haemorrhages into the retina, pappillo-edema & progressive renal disease- cardiac failure
  17. 17. SECONDARY(ACCELERATED) Kidney disease: retention of salt and water Endocrine disorders: Secretion of excess aldosterone and cortisol stimulates the retention of excess sodium & water by the kidneys, raising the Blood volume & pressure
  18. 18. Endocrine causes  Acromegaly - increased secretion of growth hormone in adults. Cushings syndrome – increased secretion of steroid hormone in children and adults . Pheochromocytoma - tumor of adrenal medulla. Drug such as corticosteroid and hormones like estrogen.
  19. 19. Renal causes of Hypertension Glomerulo nephritis-- acute or chronic or / and infective or non infective. . Bacterial infection of kidney-chronic pylo-nephritis. . Polycystic kidney disease – It is a genetic cystic disorder of the kidney. Apart from these any renal disease which can cause renal failure like Diabetes Mellitus will result in secondary hyper tension.
  20. 20. Risk factors Primary hypertension Age (older the risk is higher) Diet (High salt intake/ fatty diet) Physical activity (sedentary life style) Alcohol >15ml /day Obesity----BMI>30 Drugs (steroids, oral contraceptives) Stress - Chronic job stress Family history—overcrowding Ethnic groups- black africans Males
  21. 21. Diagnosis of Hypertension The gold standard for hypertension is only clinical measurement using mercury sphygmomanometer But we need to do investigations to rule out secondary causes Better to screen everyone above 40 years every year and every six months if there is a risk factor
  22. 22. Hypertensive at first visit In the first measurement if there is >220 mm hg of systolic pressure and >120 mm hg of diastolic pressure then we can call the patient as hypertensive - an emergency.
  23. 23. Symptoms No specific symptoms in majority. weakness Sub-occipital headache Restlessness. Sleepiness. Dizziness. Epistaxis– nose bleed
  24. 24. TIA = transient ischemic attack; LVH = left ventricular hypertrophy; CHD = coronary heart disease; HF = heart failure. Retinopathy Renal failure Peripheral vascular disease Complications of Hypertension: LVH, CHD, HF TIA, stroke HypertensionHypertension is a risk factoris a risk factor
  25. 25. Complications • Myocardial infarction (Heart attack) or coronary artery disease • Cerebro vascular accident / stroke • Left ventricular hypertrophy causes cardiac failure • Renal failure • Hypertensive Retinopathy
  26. 26. Investigations • We have to rule out secondary hypertension by investigating for other diseases. • Renal – urine microscopy is done to detect the presence of albumin. • Presence of RBC, Cast is an indications of glomerulo- nephritis. • Excess of WBC indicates kidney infection. • Renal doppler / technicium scan (nuclear scan) is done to know about blood supply to the kidney.
  27. 27.  Most patients will experience better control if they modify diet and exercise.  Physician advice sometimes works and should always be given along with a follow-up visit appointment to monitor both blood pressure and lifestyle change efforts.  Most of us do not do lifestyle counseling beyond simple advice and admonishment – the time factor is a problem.  Nevertheless, lifestyle modification is at the top of medical management.
  28. 28. Modification Approximate SBP reduction (range) Weight reduction 5-20 mmHg / 10 kg weight loss Adopt DASH eating plan 8-14 mmHg Dietary sodium reduction 2-8 mmHg Physical activity 4-9 mmHg Moderation of alcohol consumption 2-4 mmHg Benefits of Lifestyle Modification
  29. 29. Management of patients • Diet • Use <5 gms of salt per day • Avoid oily food / fatty diet • Low calorie high fiber diet • Exercise • Brisk walking, jogging, Swimming etc… Avoid smoking & alcohol.
  30. 30. Average Percent Reduction Stroke incidence 35–40% Myocardial infarction 20–25% Heart failure 50% TROPHY Study ACC 2006: Even lowering BP in those with pre-HTN appears to reduce incidence of new HTN by up to 60%
  31. 31. Drugs For Hypertension • Usually divided into 4 categories: • Diuretics • ACE (Angiotensin converting enzyme) inhibitors and AT receptor blockers • Beta blockers • CCB (calcium channel blockers) • vasodilators
  32. 32. ACE inhibitors Blocks the conversion of Angiotensin to Renin by inhibiting angiotensin converting enzyme Eg: Enalapril , Lisinopril. • Side effects • Produce dry cough • Altered taste sensations (dysguesia)
  33. 33. AT receptors blocker • More potent than ACE inhibitors - it blocks the receptors on which enzymes will act Eg : Losartan
  34. 34. Beta blockers Beta 1:cardiac selective ( Eg: Atenolol ) Non cardiac selective beta blockers ( Eg:Timolol, Propanalol). Beta blockers with intrinsic sympathomimetic activity.
  35. 35. Beta Blockers • Mechanism of action: • Acts on the beta adrenergic receptors. Side effects: • Can precipitate asthma in asthmatics-Beta receptors are present on the bronchus causing broncho constriction. • Decreases the cardiac output as well as the heart rate. • Can increase the cholesterol level. • Can mask hypoglycemia in diabetics
  36. 36. Calcium channel blockers(CCB) Allows peripheral vaso dilatation Causes decrease in the peripheral vascular resistance Very safe during pregnancy  Eg: Nifidepine, Amlodepine. Side effect: Postural hypotension, Headache, Edema, Tachycardia
  37. 37. Other drugs • Diuretics Eg: Thiazide diuretics, Hydro chlor thiazide • Alpha blockers: Prazosin • Vasodilators: Hydralazine and sodium nitroprusside • Centrally acting drugs: Methyldopa, Arkamine
  38. 38. Management of Hypertension • Depends upon the blood pressure • If person is pre-hypertensive or stage 1 is – life style modification should be done first. • Diet and exercises are first modes to control mild hypertension • If Blood pressure is high – Polypharmacy 3 or 4 drugs can be given.
  39. 39. Some guidelines for drugs • If the patient has • Renal problem – ACE inhibitors • Diabetes mellitus – ACE inhibitors • Asthma – ACE inhibitors • Diabetic / pregnancy – CCB • Anxiety /hyperthyroidism – Beta blockers
  40. 40. Hypertensive emergencies • They may result in end organ damage e,g., Kidney retina • Blood pressure should be reduced fast to prevent end organ damage. Drugs commonly used are: • Alpha blockers –Prazosin • Vasodilators – Sodium nitroprusside / Nitrates • Alpha + beta blockers – Labatelol • CCB - Nifedepine
  41. 41. Barriers to Controlling Hypertension Healthcare System Patients Providers
  42. 42. The Initial Confrontation of the HTN Problem Upon making a diagnosis of HTN, tell patient the BP reading and what it should be (provide a written copy). Prepare patient for the probable necessity for polypharmacy to control BP with a minimum of side effects Advise Home BP measurement (135/85 mmHg is considered to be hypertensive). Table 28. JNC 7 Report. Hypertension. 2003;42(6):1240.
  43. 43. Self-Measurement of BP  Provides information useful for: 1. assessing response to antihypertensive Rx 2. improving adherence with therapy 3. evaluating white-coat HTN  Home BP is more strongly related to target organ damage and has better prognostic accuracy than office BP.
  44. 44. Thank you for your patience

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