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EMBRYONA
CARCINOM
ETIOLOGY
•Embryonal carcinoma is a NON-SEMINOMATOUS
germ cell tumour characterized by primitive epithelial
cells with mark...
More aggressive than seminomas .
AGE GROUP : 20 -30 yrs.
2nd most common germ cell tumour -20% cases.
More than 2/3rd ...
MORPHOLOGY
•GROSS
•SIZE: Smaller than seminoma & do not replace entire testis
External surface:
smooth &
glistening
Cut surface:
1) has a
variegated
appearance
2)Poorly
demarcated
margins
3)Areas of
haemorrhage/necrosis
common
4) Tumour extends
into tunica albuginea ,
epididymis or
spermatic cord
MICROSCOPY
•Pattern – the tumour cells are arranged in ALVEOLAR / TUBULAR /
PAPILLARY patterns .
TUBULAR PAPPILLARY
They lack well formed glands with basally
situated nuclei and atypical cytoplasm.
More undifferentiated tumour shows
sheet/cluster of cells
Cells having epithelial appearance are large &
anaplastic.
Cell borders are usually indistinct.
Considerable variation in cell & nuclear size and
shape .
Nuclei are hyperchromatic with prominent
nucleoli .
Mitotic figures and tumour cells are frequent.
IMMUNOHISTOCHEMISTRY
Positive for : OCT ¾ & PLAP( placental alkaline phosphatase)
Positive for : cytokeratin & CD30
Neg...
embryonal carcinoma
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embryonal carcinoma

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embryonal carcinoma

  1. 1. EMBRYONA CARCINOM
  2. 2. ETIOLOGY •Embryonal carcinoma is a NON-SEMINOMATOUS germ cell tumour characterized by primitive epithelial cells with marked pleomorphism and various histologic patterns. It may present in pure form but often is part of a mixed germ cell tumour. The most accepted theory on the development of germ cell tumours involves an initiating event that causes foetal gonocytes to undergo abnormal cell division. DEFINITION
  3. 3. More aggressive than seminomas . AGE GROUP : 20 -30 yrs. 2nd most common germ cell tumour -20% cases. More than 2/3rd of patients metastases – only 10% shows symptoms. the more common sites of metastasis are the retroperitoneum, lung, and liver.
  4. 4. MORPHOLOGY •GROSS •SIZE: Smaller than seminoma & do not replace entire testis
  5. 5. External surface: smooth & glistening Cut surface: 1) has a variegated appearance
  6. 6. 2)Poorly demarcated margins 3)Areas of haemorrhage/necrosis common
  7. 7. 4) Tumour extends into tunica albuginea , epididymis or spermatic cord
  8. 8. MICROSCOPY •Pattern – the tumour cells are arranged in ALVEOLAR / TUBULAR / PAPILLARY patterns . TUBULAR PAPPILLARY
  9. 9. They lack well formed glands with basally situated nuclei and atypical cytoplasm.
  10. 10. More undifferentiated tumour shows sheet/cluster of cells
  11. 11. Cells having epithelial appearance are large & anaplastic.
  12. 12. Cell borders are usually indistinct.
  13. 13. Considerable variation in cell & nuclear size and shape .
  14. 14. Nuclei are hyperchromatic with prominent nucleoli .
  15. 15. Mitotic figures and tumour cells are frequent.
  16. 16. IMMUNOHISTOCHEMISTRY Positive for : OCT ¾ & PLAP( placental alkaline phosphatase) Positive for : cytokeratin & CD30 Negative for c-KIT(CD 117) & EMA There is also increase in alpha fetoprotein & Lactic acid dehydrogenase . CD 30 OCT 3/4

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