•Embryonal carcinoma is a NON-SEMINOMATOUS
germ cell tumour characterized by primitive epithelial
cells with marked pleomorphism and various histologic
patterns. It may present in pure form but often is part
of a mixed germ cell tumour.
The most accepted theory on the development of germ
cell tumours involves an initiating event that causes
foetal gonocytes to undergo abnormal cell division.
More aggressive than seminomas .
AGE GROUP : 20 -30 yrs.
2nd most common germ cell tumour -20% cases.
More than 2/3rd of patients metastases – only 10% shows symptoms.
the more common sites of metastasis are the retroperitoneum, lung,
•SIZE: Smaller than seminoma & do not replace entire testis
1) has a
4) Tumour extends
into tunica albuginea ,
•Pattern – the tumour cells are arranged in ALVEOLAR / TUBULAR /
PAPILLARY patterns .
They lack well formed glands with basally
situated nuclei and atypical cytoplasm.
More undifferentiated tumour shows
sheet/cluster of cells
Cells having epithelial appearance are large &
Considerable variation in cell & nuclear size and
Nuclei are hyperchromatic with prominent
Mitotic figures and tumour cells are frequent.
Positive for : OCT ¾ & PLAP( placental alkaline phosphatase)
Positive for : cytokeratin & CD30
Negative for c-KIT(CD 117) & EMA
There is also increase in alpha fetoprotein & Lactic acid