Ezastatin ( The Art of Combination Therapy)

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Ezastatin combines 10 mg ezetimibe with 40 mg atorvastatin
Marked improvement in lipid profile compared to plain Atorvastatin.
Reduction in Oxidized LDL, an effect not achieved by up-titration of statin dose.
Reduces cholesterol absorption specially in diabetic patients with CAD.
Ezastatin with 40 mg atorvastatin concentration to benefit from pleiotropic effects of atorvastatin.
Ezastatin reduces CIMT compared to standard and aggressive therapy.
Higher safety profile than maximizing atorvastatin dose to 80mg

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  • Very High Risk Patients:1-Documented CVD whether by invasive such as coronary angiography or non invasive such as stress echocardiography, previous MI , PCI , CABAG ,and other arterial revascularization procedures , stroke , PAD2-Patients with Type-2 Diabetes or Type-1 with target organ damage ( Microalbuminuria )3-Patient with moderate to sever CKD with GFR < 604-A calculated 10 risk score >= 10
  • Ezastatin ( The Art of Combination Therapy)

    1. 1. Coronary Artery Disease Risk
    2. 2. Coronary Artery Disease Risk
    3. 3. Are LDL-C Goals The Same ForAll Patients With Dyslipideamia?
    4. 4. Coronary Artery Disease RiskATP III modification
    5. 5. Debate Can we achieve these goals with Statinmono therapy alone ? At which Statin concentration ? Is it enough to achieve normal lipid profileonly ? what else ? What about increase exogenouscholesterol absorption in diabetics?
    6. 6. Coronary Artery Disease RiskStatins monotherapy limitations
    7. 7. Coronary Artery Disease RiskStatins monotherapy limitations
    8. 8. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    9. 9. MANAGEMENT OF DIABETICDYSLIPIDEMIA: RECENTADVANCES IN COMBINATIONTHERAPY
    10. 10. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    11. 11. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    12. 12. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    13. 13. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    14. 14. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    15. 15. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    16. 16. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    17. 17. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    18. 18. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    19. 19. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    20. 20. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    21. 21. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    22. 22. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    23. 23. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    24. 24. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    25. 25. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
    26. 26. Why Ezastatin Ezastatin combines 10 mg ezetimibe with 40 mg atorvastatin Marked improvement in lipid profile compared to plainAtorvastatin. Reduction in Oxidized LDL, an effect not achieved by up-titrationof statin dose. Reduces cholesterol absorption specially in diabetic patientswith CAD. Ezastatin with 40 mg atorvastatin concentration to benefit frompleiotropic effects of atorvastatin. Ezastatin reduces CIMT compared to standard and aggressivetherapy. Higher safety profile than maximizing atorvastatin dose to 80mg.
    27. 27. Ezastatinatorvastatin + ezetimibeFill the unmet need inlipid lowering management
    28. 28. THANK YOU

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