Metal Complexes as DNA Intercalators HONG-KE LIU &PETER J. SADLER Fatemeh BabaeiIntercalation induces structural distortions
Ethidium intercalated between two adenine-thymine base pairsThese molecules cause structural modifications that can lead to functional changes, oftento inhibition of transcription and replication and DNA repair processes, which makeintercalators potent mutagens.
Two major modes of inercalation Classical intercalation Threading intercalation benzo[α]pyrene acridine-4-carboxamides Inserted between GpG base pair Occupy and interact with both majorThat form the top and the bottom of and minor grooves of DNA intercalation site
Intercalation by Inert Square-Planar and Octahedral Metal ComplexesSquare-planar complexes containingaromatic fragments can bind to DNAby intercalation without direct metalcoordination to DNA bases. Octahedral metallointercalators permit the targeting of specific DNA sites by matching the shape, symmetry, and functionalities of the metal complex to that of the DNA target.
Interaction of Metallointercalators with DNAMetallo intercalation Metallo insertion
Intercalation by Dual-Function Metal Complexes with σ-Bonded Side Arm IntercalatorsWhen do the Dual function happen?When the aromatic side arms or areneligands can intercalate between DNAbases while the metal coordinatesdirectly to a DNA base.N7 Increasing the cytotoxicity by adding pyridine and quinoline Using as an anticancer drug pyridine and quinoline have intercalation with DNA duplex