Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

sistem limfatik

1,253 views

Published on

Published in: Health & Medicine, Technology
  • Be the first to comment

  • Be the first to like this

sistem limfatik

  1. 1. Lecture OverviewLecture Overview Lymphatic System and Components – What is lymph and how does it travel? General Immune Reaction- Inflammation – What is one function of the cells carried in lymph? Selected Topics in Immunity
  2. 2. Lymphatic SystemLymphatic System Absorbs excess fluid from the tissues Returns this fluid to the circulatory system or the heart Additional function in Immunity
  3. 3. Components of the LymphaticComponents of the Lymphatic SystemSystem Lymph Lymphatic Tissue Lymphatic Vessels Thymus Bone Marrow Spleen
  4. 4. LymphLymph Lymph – The clear fluid absorbed by the lymphatic system Lymphatic Tissue – Clusters of Lymphocytes and macrophages
  5. 5. Lymphatic TissueLymphatic Tissue Malt: (Mucosa Associated Lymphatic Tissue) – Diffuse array of lymphocytes found along body passages in mucous membranes. – Examples of malt: lining of the stomach and respiratory tract Lymph nodules: – Dense clusters of Lymphocytes – Transient: pop up during infection
  6. 6. Lymphatic VesselsLymphatic Vessels  Carry and Transport Lymph and proteins  Similar Structure to veins – Tunica Interna: Thin inner lining and valves – Tunica Media: Elastic fibers and Smooth Muscle – Tunica Externa: Thin Outer Layer
  7. 7. Lymphatic FiltersLymphatic Filters Lymph Nodes- Screen and Filter Lymph for infectious particles Spleen- Screen and Filter Blood for old, dead cells and infectious particles
  8. 8. Subclavian 2 collecting Trunks 6 Lymphatic Trunks More Collecting Vessels Lymph Nodes Collecting Vessels Lymphatic Vessels
  9. 9. Lymphatic MovementLymphatic Movement No pump Rhythmic contraction of the lymph vessels Skeletal Muscles How is backflow prevented?
  10. 10. Immune Cell GeneratorsImmune Cell Generators Bone Marrow- Makes B- Cells Thymus- Makes T- Cells
  11. 11. ThymusThymus
  12. 12. Break for Dynamic Human
  13. 13. InflammationInflammation Non-specific response to tissue trauma or infection
  14. 14. 44 signs of Inflammationsigns of Inflammation
  15. 15. 44 signs of Inflammationsigns of Inflammation Redness Swelling Heat Pain What’s the purpose of pain?
  16. 16. Purpose of InflammationPurpose of Inflammation Remove Invading Pathogens Remove Debris of Damaged Tissues Initiate Tissue Repair
  17. 17. Mediators of InflammationMediators of Inflammation Chemical Messengers Leukocyte
  18. 18. Chemical MessengersChemical Messengers  Released by mast cells in response to damage  Bradykinin, Histamine, and Leukotrienes – Increases Local Blood Flow to distressed area  Stimulates Vasodilation  Increases Permeability of Capillaries  What’s Accomplished?
  19. 19. Chemical MessengersChemical Messengers Bradykinin, Histamine, and Leukotrienes – Increases Local Blood Flow  Stimulates Vasodilation  Increases Permeability of Capillaries What’s Accomplished? – Heats area causes redness and swelling – Dilutes toxins and helps Remove waste – Supplies oxygen and nutrients for tissue repair
  20. 20. Pain ResponsePain Response Purpose? Causes?
  21. 21. Pain ResponsePain Response Purpose? Prevents further injury to area. Causes? – Direct Nerve Damage – Pressure from Swelling – Chemical Stimulation particularly bradykinin
  22. 22. Leukocyte DeploymentLeukocyte Deployment Leukocyte: any white blood cell including T cells, B cells, granulocytes, platelets, basophils, mast cells, monocytes and macrophages Leukocytes Migrate toward inflammed area Why? TO KILL and RECRUIT
  23. 23. Leukocyte DeploymentLeukocyte Deployment Leukocytes Migrate to inflammed tissue How? 1. Margination or pavementing: To migrate to the wall of a capillary 2. Diapedesis: Passage of blood cells through vessel wall into tissue 3. Chemotaxis: Movement of a cell towards or away a chemical source
  24. 24. What do the leukocytes planWhat do the leukocytes plan to do?to do? Phagocytosis: release of toxic chemicals Recruit more leukocytes
  25. 25. PhagocytosisPhagocytosis Leukocytes consume and destroy foreign invaders and dead cells Ejected as Pus
  26. 26. Break forBreak for Dynamic HumanDynamic Human
  27. 27. Selected Topics in ImmunitySelected Topics in Immunity

×