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sistem limfatik


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sistem limfatik

  1. 1. Lecture OverviewLecture Overview Lymphatic System and Components – What is lymph and how does it travel? General Immune Reaction- Inflammation – What is one function of the cells carried in lymph? Selected Topics in Immunity
  2. 2. Lymphatic SystemLymphatic System Absorbs excess fluid from the tissues Returns this fluid to the circulatory system or the heart Additional function in Immunity
  3. 3. Components of the LymphaticComponents of the Lymphatic SystemSystem Lymph Lymphatic Tissue Lymphatic Vessels Thymus Bone Marrow Spleen
  4. 4. LymphLymph Lymph – The clear fluid absorbed by the lymphatic system Lymphatic Tissue – Clusters of Lymphocytes and macrophages
  5. 5. Lymphatic TissueLymphatic Tissue Malt: (Mucosa Associated Lymphatic Tissue) – Diffuse array of lymphocytes found along body passages in mucous membranes. – Examples of malt: lining of the stomach and respiratory tract Lymph nodules: – Dense clusters of Lymphocytes – Transient: pop up during infection
  6. 6. Lymphatic VesselsLymphatic Vessels  Carry and Transport Lymph and proteins  Similar Structure to veins – Tunica Interna: Thin inner lining and valves – Tunica Media: Elastic fibers and Smooth Muscle – Tunica Externa: Thin Outer Layer
  7. 7. Lymphatic FiltersLymphatic Filters Lymph Nodes- Screen and Filter Lymph for infectious particles Spleen- Screen and Filter Blood for old, dead cells and infectious particles
  8. 8. Subclavian 2 collecting Trunks 6 Lymphatic Trunks More Collecting Vessels Lymph Nodes Collecting Vessels Lymphatic Vessels
  9. 9. Lymphatic MovementLymphatic Movement No pump Rhythmic contraction of the lymph vessels Skeletal Muscles How is backflow prevented?
  10. 10. Immune Cell GeneratorsImmune Cell Generators Bone Marrow- Makes B- Cells Thymus- Makes T- Cells
  11. 11. ThymusThymus
  12. 12. Break for Dynamic Human
  13. 13. InflammationInflammation Non-specific response to tissue trauma or infection
  14. 14. 44 signs of Inflammationsigns of Inflammation
  15. 15. 44 signs of Inflammationsigns of Inflammation Redness Swelling Heat Pain What’s the purpose of pain?
  16. 16. Purpose of InflammationPurpose of Inflammation Remove Invading Pathogens Remove Debris of Damaged Tissues Initiate Tissue Repair
  17. 17. Mediators of InflammationMediators of Inflammation Chemical Messengers Leukocyte
  18. 18. Chemical MessengersChemical Messengers  Released by mast cells in response to damage  Bradykinin, Histamine, and Leukotrienes – Increases Local Blood Flow to distressed area  Stimulates Vasodilation  Increases Permeability of Capillaries  What’s Accomplished?
  19. 19. Chemical MessengersChemical Messengers Bradykinin, Histamine, and Leukotrienes – Increases Local Blood Flow  Stimulates Vasodilation  Increases Permeability of Capillaries What’s Accomplished? – Heats area causes redness and swelling – Dilutes toxins and helps Remove waste – Supplies oxygen and nutrients for tissue repair
  20. 20. Pain ResponsePain Response Purpose? Causes?
  21. 21. Pain ResponsePain Response Purpose? Prevents further injury to area. Causes? – Direct Nerve Damage – Pressure from Swelling – Chemical Stimulation particularly bradykinin
  22. 22. Leukocyte DeploymentLeukocyte Deployment Leukocyte: any white blood cell including T cells, B cells, granulocytes, platelets, basophils, mast cells, monocytes and macrophages Leukocytes Migrate toward inflammed area Why? TO KILL and RECRUIT
  23. 23. Leukocyte DeploymentLeukocyte Deployment Leukocytes Migrate to inflammed tissue How? 1. Margination or pavementing: To migrate to the wall of a capillary 2. Diapedesis: Passage of blood cells through vessel wall into tissue 3. Chemotaxis: Movement of a cell towards or away a chemical source
  24. 24. What do the leukocytes planWhat do the leukocytes plan to do?to do? Phagocytosis: release of toxic chemicals Recruit more leukocytes
  25. 25. PhagocytosisPhagocytosis Leukocytes consume and destroy foreign invaders and dead cells Ejected as Pus
  26. 26. Break forBreak for Dynamic HumanDynamic Human
  27. 27. Selected Topics in ImmunitySelected Topics in Immunity