The main problems in big companies are well known of product managers and entrepreneurs.
loss of ownership and loss of empowerment (it's like nobody is never responsible for anything),
which all leads to big cycle and lead time.
We had all those problems when we started to build chooseyourboss.com within the biggest french web based classifieds company. our marketing team was working for 4, or 5 products at the same time. Their role wasn't always clear : were they working on the product? On the growth only?
Our sales were in the same situation : they had a big product making millions, and for most of them, were afraid to sell a new product without any 'proof' that it was going to make it.
I imagine that a lot of product managers and intrapreneurs have seen the same situations.
What helped us is a framework we crafted during 18 months, that we called experiments. Experiments are testable and measurable actions that allow to validate or invalidate assumptions and hypothesis we make everyday as product managers.