Benetos 1

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  • P332 Figure 5.6
  • Benetos 1

    1. 1. Athanase Benetos University of Nancy, France Can we slow down the aging process with caloric restriction? 4th International Seminar in Preventive Geriatrics Athens, April 2011
    2. 2. (1214-1294) The father of the prolongevity movement “Secret Arts of The Past” Roger Bacon We live short because we live immoral and unhealthy lives
    3. 3. Roger Bacon <ul><li>Controlled diet </li></ul><ul><li>Proper rest </li></ul><ul><li>Exercise </li></ul><ul><li>Moderation life style </li></ul><ul><li>Good hygiene </li></ul><ul><li>Inhaling the breath of a young virgin </li></ul>
    4. 4. Is there one or several « anti-aging » diets?
    5. 5. Korean team filming how Azeri villagers prepare yogurt. Shirali died at 168 years-old
    6. 6. Fish Oils
    7. 8. Mediterranean- Cretian Diet
    8. 9. <ul><li>Vital energy with aging </li></ul><ul><li>The solution : Moderation </li></ul>1467-1569 Luigi Cornaro “ The art of living long” “ The Sober life” Eating less
    9. 11. Nutrient caloric intake ‘dose response’ and life span in the lab fly. Life Span, days Food Concentration (x normal) Food Concentration (x normal)
    10. 13. (A) A 19-year-old male rhesus monkey weighing 13.6 kg on the control diet. (B) A 19-year-old male rhesus monkey weighing 7.9 kg on CR for 17 years. (C) A 38-year-old (estimated age) male rhesus monkey weighing 6.8 kg on CR for 17 years. He died 18 April 2004 at a minimal estimated age of 40 years, but he could have been as old as 44 years, making him one of the oldest recorded of this species. Aging in Rhesus Monkeys: Relevance to Human Health Interventions George S. Roth, Julie A. Mattison, Mary Ann Ottinger, Mark E. Chachich, Mark A. Lane, and Donald K. Ingram Science 2004: 1423-1426 .
    11. 16. What Calorie Restriction is? Control group: 2,500 kcal/day, 17% protein, 52% carbohydrates, 31% fat, (11% saturated fat). CR subjects: 1,650 kcal/day (p<0.0001 vs. controls), 23% protein, (p <0.0001 vs. control group), 49% carbohydrates, 28% fat, (6% saturated fat) Daily salt intake was lower in the CR group (2.6 + 1.3g vs. 3.4 + 1.0g; p<0.007).
    12. 17. Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans Timothy E. Meyer, PHD St. Louis, Missouri and Rome, Italy JACC Vol. 47, No. 2, 2006
    13. 18. Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans Timothy E. Meyer, PHD St. Louis, Missouri and Rome, Italy JACC Vol. 47, No. 2, 2006
    14. 19. Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans Timothy E. Meyer, PHD St. Louis, Missouri and Rome, Italy JACC Vol. 47, No. 2, 2006
    15. 21. Data from People on CR <ul><li>18 persons from the “Caloric Restriction Optimal Nutrition Society” </li></ul><ul><li>Body fat: Controls = 22%; CR = 7% </li></ul>Fontana et al. (2004) PNAS 101 : 6659-63
    16. 22. Carotid IMT of the common carotid artery was 40% less in the CR than in the comparison group (P < 0.0001). None of the individuals on CR had evidence of atherosclerotic plaque, defined as an IMT of more than 1.0 mm and an increase of at least 100% compared to an adjacent wall segment Fontana et al. (2004) PNAS 101 : 6659-63
    17. 23. Improve your life style <ul><li>Eat better </li></ul><ul><li>Avoid obesity </li></ul><ul><li>Make exercise </li></ul>
    18. 24. I don ’ t know if life would be longer (if we use CR) but I am sure that life would seem much longer! Jay Olshansky, Chicago

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