1.
APPLICATION of MOUSE MODEL
for Effective Evaluation of FMD Vaccine
l Efficacy evaluation of FMD vaccines has been conducted in ta
rget animals.
→ expensive, time and labor for the experiments.
l In the present study, we made a series of lethal challenge viruse
s for adult C57BL/6 mice.
l Types O, A, and Asia1 was evaluated in the mouse model.
l In-house and commercial vaccines demonstrated vaccine-mediated protec
tion in a dose-dependent manner.
Seo-Yong Lee1
, Mi-Kyeong Ko1
, Kwang-Nyeong Lee1
, Joo-Hyung Choi1, Su-Hwa
You1
, Hyun-Mi Pyo1
, Myoung-Heon Lee1
, Byounghan Kim1
, Jong-Soo Lee2
, Jo
ng-Hyeon Park1
1 Center for FMD Vaccine Research, Animal and Plant Quarantine Agency, Republic of Korea,

2.
Strategy for obtaining lethal FMDVs and charact
erizing the pathogenic viruses

3.
Evaluation of the experimental in-house va
ccines in the mouse model

4.
Evaluation of the commercial type O FMD v
accine in the mouse model

5.
Variation of mouse survival according to the vario
us adjuvants and various challenge points
Challenge after type Asia1 vaccination

6.
l At least, using this methods, we can predict whi
ch one is better in short times
l We propose that FMD vaccine evaluation shoul
d be carried out using mouse-adapted challenge vi
ruses as a swift, effective efficacy test of experime
ntal or commercial vaccines.
Conclusions