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Fanconi Anemia:The Molly Nash Story
What is Fanconi Anemia?• Genetic disorder• Causes bone marrow failure• Causes leukemia• Usually leads to death in early  c...
Symptoms• Abnormal hands and arms• Skeleton problems (hips,  spine)• Skin discoloration• Short stature• Mental retardation...
Molly Nash was  diagnosed with  Fanconi Anemiashortly after she was         born
Molly’s Timeline    Birth                    3 years             4 years         6 yearso   hand                   bone ma...
Treatment•Bone Marrow Transplant (BMT)  • Cells from the patient’s bone marrow are replaced     by                        ...
The Nash Family•Lisa Nash underwent in vitro fertilization•Doctors used pre-implantation geneticdiagnosis (PGD)
Pre-Implantation Genetic    Diagnosis (PGD)
The Nash Family•The Nashs selected embryos that:   o   did not have FA   o   were a protein match with Molly (this       i...
Molly Nash - Treatment•Molly received umbilical cord blood cellsfrom her baby brother when she was 6years old•She is no lo...
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Intro to fanconi anemia and molly nash pdf

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Intro to fanconi anemia and molly nash pdf

  1. 1. Fanconi Anemia:The Molly Nash Story
  2. 2. What is Fanconi Anemia?• Genetic disorder• Causes bone marrow failure• Causes leukemia• Usually leads to death in early childhood
  3. 3. Symptoms• Abnormal hands and arms• Skeleton problems (hips, spine)• Skin discoloration• Short stature• Mental retardation• Digestive system problems• Hearing problems• Bone marrow failure• Susceptible to infections• Predisposition to leukemia and other cancers
  4. 4. Molly Nash was diagnosed with Fanconi Anemiashortly after she was born
  5. 5. Molly’s Timeline Birth 3 years 4 years 6 yearso hand bone marrow failure pre-leukemia successful cord abnormalities blood transplanto hip dislocationo deaf in the left earo heart abnormalitieso abnormal digestive system
  6. 6. Treatment•Bone Marrow Transplant (BMT) • Cells from the patient’s bone marrow are replaced by OR donor bone donor umbilical marrow cells chord blood cells
  7. 7. The Nash Family•Lisa Nash underwent in vitro fertilization•Doctors used pre-implantation geneticdiagnosis (PGD)
  8. 8. Pre-Implantation Genetic Diagnosis (PGD)
  9. 9. The Nash Family•The Nashs selected embryos that: o did not have FA o were a protein match with Molly (this increased the chances that the bone marrow transplant would be successful)
  10. 10. Molly Nash - Treatment•Molly received umbilical cord blood cellsfrom her baby brother when she was 6years old•She is no longer at risk for leukemia•She still needs treatments for herdigestive and skeletal systemabnormalities

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