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The mHealth “revolution” has promised to deliver in-home healthcare that parallels the care we might receive in a physician’s office. However, the panacea of digital health has proven to be more problematic and messy than its vision, especially for collecting and interpreting medical quantities from the home. In this talk I will discuss several successful projects for sensing medical quantities from a mobile phone using the embedded sensors (i.e., camera, microphone, accelerometer) and how these projects can increase compliance as well as enhance doctor patient relationships. I will focus on the reliability and calibration of the sensing and the role of computer scientists and engineers in the future of mHealth.