Endobiogeny a Global Overview

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  • The image on the left illustrates the focused view of a reductionist model. It looks at the part at the expense of the wholeThe image on the right illustrates the holistic view, which contextualizes man within the circadian cycle and appreciates the dynamism of his physiology, but lacks a reflective analysis of the particular components of adaptability and adaptation
  • If one accepts the premise that the human organism is a true system, the level of activity of this system must be considered. Most researchers engaging in systems research are going down the level of systems analysis to the most basic rather than going up to higher levels of complexity. Biological information is encoded in a multi-scale information hierarchy: DNA, RNA, proteins, interactions, biological networks, cells, tissues and organs, individuals and, finally, ecologies. The important point is that the environment impinges upon each of these levels of the hierarchy and modulates the digital informational output from the genome. Thus, systems-level investigations demand the collection of data at each relevant level of the hierarchy between the phenotypic measurement (features of the cell) and the core digital genome—Leroy Hood et al., Institute for Systems Biology39In a global systems approach, if one takes the eye, we can demonstrate how a global systems approach contextualizes retinal cells within a larger context while appreciating every level of the system. The images, from top left clockwise:Top Left: Retinal cellsTop Right: Contextualization of retinal cells within the entire occular apparatusBottom Right: Contextualization of the eye within the context of light/dark variations, pineal glandBottom Left: Contextualization of the eye, the pineal gland, and adaptability at the level of the adrenals and the thyroid
  • It is a false dichotomy to chose between reductionism and holism. Endobiogeny encompasses both, which his what is required for a global approach to systems theory.
  • From the unicity of metabolism arises the dualism of Catabolism and Anabolism. From Dualism arises Multiplicity in the alternation of two sets of catabolic and anabolic endocrine axes. From this arises further multiplicity of central and peripheral activity in its strictly vertical control mechanisms of classical feedback loops.
  • The image in the top right illustrates the network of relationships between various proteins within a single cell within a 24 hour period of time.
  • Over 60% of the biomarkers used in the BoF are derived from the bone marrow, from these three types of cells
  • NocturnalAnti-oxidant: most powerful endogenousAnti-inflammatory, free radical scavengerAnti-tumoral: Night-shift nurses have a higher incidence of breast cancer than day-shift nursesReorganizes cerebral connectionsDiurnalProtects skin against UV damageStimulates pancreatic enzymesGastric motility (patients with Irritable Bowel have low AM melatonin levels)Adrenal adaptability (c.f. next slide)Thyroid adaptability (c.f. next slide)
  • First animation: Melatonin in its well-known role in sleepSecond Animation: Hypo-functioning pineal activity in the face of insufficient adrenal activity: relaunching of Alpha, CRF, ACTH Third animation: Hypo-functioning pineal activity in the face of thyroid insufficiencyFourth animation: Hyper-functioning pineal activity and relaunching of DA and TRH by diversion of Serotonin away from metabolism into Melatonin
  • Endobiogeny a Global Overview

    1. 1. ASEMIP Endobiogeny: A global approach to systems biology Kamyar M. Hedayat, MD President, American Society of Endobiogenic Medicine and Integrative Physiology (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    2. 2. ASEMIP INTRODUCTION ““Living systems are organized in such a way that they form multi-leveled structures, each level consisting of subsytems which are wholes in regard to their parts, and parts with respect to the larger wholes ”--Fritjof Capra, The turning point: science, society and the rising culture, p. 43 (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    3. 3. ASEMIP Differing views REDUCTIONISM HOLISM (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    4. 4. ASEMIP Systems Theory (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology “Systems theory looks at the world in terms of the interrelatedness and interdependence of all phenomenon, and in this framework an integrated whole whose properties cannot be reduced to those of its parts is called a system.” Fritjof Capra, The turning point: science, society and the rising culture, p. 43
    5. 5. ASEMIP Determining level of study (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    6. 6. ASEMIP OVERVIEW OF ENDOBIOGENY (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    7. 7. ASEMIP A false dichotomy Reductionism Quantitative Function of the parts Hierarchy Categorical Separate Independent Static Control Holism Qualitative Function of the System Relationships Individualized Interconnected Interdependence Dynamic Creative chaos (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology ENDOBIOGENY
    8. 8. ASEMIP Endobiogeny: A theory of terrain • Terrain: functional expression of structural constitution in its internal equilibrium – Constitution: Genetic heritage, potential capacity of the structure – Structure: materialized constitutive elements that assure life. The achievement of constitution – Function: all the biologic and metabolic mechanics that assure functioning of structure and dynamics of the organism
    9. 9. ASEMIP Manager of the System • In order to ensure the integrity of the system, the manager must possess 3 qualities: 1) Ubiquity of interaction with each structural element 2) Constancy of relationship with those elements 3) Auto-regulation. • The Endocrine system is the manager of the terrain and the system most worthy of study (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    10. 10. ASEMIP Towards an Integrative Physiology (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology METABOLISM CATABOLISM ANABOLISMANABOLISM CATABOLISM CRH ACTH ADRENALS LHRH FSH LH GONADS TRH TSH THYROID GHRH GH PL PANCREASπΣ αΣ βΣ Corticotropic Gonadotropic Thyrotropic Somatotropic ANS ENDOCRINE MANAGEMENT
    11. 11. ASEMIP IntegrativePhysiology (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    12. 12. ASEMIP Elements of the Endobiogenic Method • Theory of Terrain • History • Physical Exam • Systems-based biomarker interpretation • Treatment – Rational clinical phytotherapy – Alimentation – Lifestyle (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    13. 13. ASEMIP THE BIOLOGY OF FUNCTIONS "The new mathematics...is one of relationships and patterns. It is qualitative rather than quantitative and thus embodies the shift of emphasis that is characteristic of systems thinking—from objects to relationships, from quantity to quality, from substance to pattern." Fritjof Capra (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    14. 14. ASEMIP Need to use blood-based biomarkers Advantages • Objective • Quantitative • Accurate • Reproducible • Minimally invasive Short-comings • Binary • Reductionist • Confusion of – Cause vs. Effect – Cause vs. Effect vs. Mechanism (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    15. 15. ASEMIP Wisdom of using blood Blood and Physiology • The life of the flesh is in the blood (Lev. 17:10) • The blood is the life (Deut 12:23) Blood, Thought and Emotions • And indeed We have created man, and We know whatever thoughts his inner self develops, and We are closer to him than (his) jugular vein. (50:16) (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    16. 16. ASEMIP Cellular Elements Image 2: (left to right) Erythrocytes, Thrombocytes, Leukocytes
    17. 17. ASEMIP Table 1: Biomarkers Origin Biomarker Bone Marrow Red blood cell White blood cell, total Neutrophil Lymphocytes Eosinophils Monocytes Basophils Hemoglobin Platelets Marrow-Blood interaction Erythrocyte sedimentation rate Bone Stroma Enzymes Osteocalcin Alkaline phosphatase bone isoenzyme General Enzymes Lactate dehydrogenase Creatine phosphokinase Endocrine: Pituitary Thyroid stimulating hormone Electrolytes Potassium Calcium, total serum 70% bone and blood 30% other
    18. 18. ASEMIP Direct and Indirect ratios Direct Indices • Direct relationship of biomarkers • Genital Ratio (GR) – RBC/WBC • Adaptation Index – Eosinophils/Monocytes Indirect Indices • Indirect relationship of direct indexes and other indirect indexes • Genital ratio corrected =(RBC/PMI) / (WBC/LMI)
    19. 19. ASEMIP CASE STUDIES IN PINEAL PHYSIOLOGY (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    20. 20. ASEMIP Pineal physiology: Seasonal entrainment • Seasonal entrainment – Shorter duration of light, greater production of melatonin – Pineal adapts adrenal gland to increase activity during the winter months – Pineal adapts thyroid in similar fashion • Cosmobiology: evaluates the effects of cosmologic events such as solar flares and lunar cycles on human physiology
    21. 21. ASEMIP Pineal Physiology: Other • Nocturnal – Anti-oxidant: most powerful endogenous – Anti-inflammatory, free radical scavenger – Anti-tumoral – Reorganizes cerebral connections • Diurnal – Protects skin against UV damage – Stimulates pancreatic enzymes – Gastric motility – Adrenal adaptability – Thyroid adaptability
    22. 22. ASEMIP Pineal Physiology πΣ Serotonin Melatonin CRF ACTH Cortisol Adaptation, Alertness, Memory Sleep (-) βMSH Dopamine TRH Imagination, Rumination, Expansive, tangential thinking, emotional labiality, explosive energy Executive thinking, Rational thought, pleasure and reward Thyroid Drive, Energy, Cell turnover and “spring cleaning” αΣ Impulsivity, Extroversion Hyperalertness, Increased perception and intake of stimuli
    23. 23. ASEMIP Review of clinical studies of melatonin and neuropsychiatric disorders Disorder Melatonin-AM Melatonin-PM Mania -  Anorexia   Bulemia  - Schizophrenia - Blunted peak Depression -  Seizures -  Aging -  Alzheimer’s -  Verster GC. Melatonin and its agonists, circadian rhythms and psychiatry. Afr J Psychiatry (Johannesbg). Feb 2009;12(1):42-46.
    24. 24. ASEMIP Indices relevant to Pineal function • Corticotropic – ACTH index – Corisol index – Adrenal cortex index • Thyrotropic – Thyroid metabolic index – Thyroid yield – TRH/TSH index • Somatotropic – Prolactin index – Peripheral Serotonin • Pineal Gland – Adaptogen index: relative level of participation of pineal gland in adaptation – βMSH/αMSH: Relative level of participation of pineal vs. pituitary in adaptation
    25. 25. ASEMIP Case 1: Insufficient pineal adaptation 10 year old boy hearing voices, death wish • 10 yo boy with anxiety, death wish from voices in head • H/O: Severe atopy: food allergies, environmental allergies, asthma, arrested growth, < 5% for weight • Symptoms – ANXIETY: mood swings, sad, but cannot express exactly what makes him feel that way; stated he wanted to kill himself due to feeling overwhelmed from hearing voices. Claims to have had visions since 2 years of age, telepathy, empathic – Asthma: daily use with constant dyspnea – Fatigue: chronic, cannot play at recess, tired in school
    26. 26. ASEMIP Case 1: Insufficient Pineal adaptation • Treatment: – Mind blend: California poppy, Annual Mercury, Cassis buds, Lithy tree buds, DOSE: 2.5 ml tid • 48 hours: Voices and death wish resolved – Treatment for asthma started 2 weeks later after biology of functions performed • 3 months: full energy, need for daily asthma inhaler resolved—went 6 months before requiring again • 12 months: Happy, healthy boy, gaining weight (6 lbs), growing in height (5.5’’), expanding list of tolerable foods, mild asthma with colds
    27. 27. ASEMIP Case 1: Biology of Functions Index Value Low High Adrenal cortex 1.62 2.7 3.3 Evoked Histamine 10,221 20 60 Thyroid metabolic 1.64 3.5 5.5 Thyroid yield 0.79 2 3 bMSH/aMSH 1.87 6 8 Prolactin 4.81 0.8 1.2 Peripheral Serotonin 0.22 1.5 7.5
    28. 28. ASEMIP Case Study 2: Excessive Pineal activity Cyclic Dysthymia • Chief Complaints: Hormonal and mood fluctuations • Symptoms – EMOTIONS: Phases last for months at a time: • Depressed, chornic fatigue easily irritated, brain fog • Suddenly improves during ovulation – 15: ADRENAL FATIGUE with late onset of puberty – 18-26: Anxiety attacks after caffeine or chocolate – 34: nearly died from traumatic birth with severe hemorrhaging became hypersensitive to noise; – 36: 8th month of pregnancy: insomnia, anemia (Hg 10), anxiety, panic attacks--started on Armor thyroid which worsened her situation; Child born with trisomy 21 – SLEEP: Variable: Cannot shut off mind when tries to sleep, hard to fall asleep; Dreams: Vivid, engaging, but not fatiguing
    29. 29. ASEMIP Case Study 2 (cont): Pineal Over-adaptation • Based on history, physical exam and biology of functions, started on following treatment • #1: Nervous tension: California poppy, Salad burnett, Yarrow, White deadnettle, Artichoke leaf, 2.5 ml BID • #2: Mood swings: Strawberry leaf, Gypsywort, Arnica, Buggleweed, Pichi, 2.5 ml bid • Magnesium oligoelement: 20 drops qAM • 6 weeks: reduction in amplitude of swings • 7 months: increased functionality and delayed onset of cyclic dysthymia and as above
    30. 30. ASEMIP Case 2: Biology of functions 10 months on treatment Index 8/30/11 6/29/12 Low High Adrenal Cortex 1.83 6.51 2.7 3.3 Thyroid index 8.93 7.94 3.5 5.5 Thyroid yield 4.85 2.93 2 3 TRH/TSH 31.13 0.19 0.33 1.7 bMSH/aMSH 9.72 9.37 6 8 Thyroid relaunching corrected 1.5 0.75 0.1 0.5 Insulin index 10.67 4.28 1.5 5 Insulin resistance 0.07 0.11 0.75 1.25
    31. 31. Summary of Pineal function
    32. 32. ASEMIP RESEARCH, LEARNING AND PRACTICE (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    33. 33. ASEMIP Endobiogeny around the world • Europe – France: Home of Endobiogeny – UK: taught in conjunction with Middlesex University – Lithuania: Taught through affiliation with medical school (starting 2014) • Americas – US: Fellowship underway – Mexico: Official form of medicine, used by public health system • North Africa – Tunisia: Masters degree in endobiogeny (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    34. 34. ASEMIP Areas of research • Cancer • Autoimmune disorders • Neuro-psychiatric disorders • Cardiovascular disorders • Septic Shock • PTSD (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology
    35. 35. ASEMIP Conclusions • Endobiogeny is a theory of terrain • Offers a Global systems approach to biology – Quantitative – Qualitative – Humanistic – Clinical solutions open to all forms of treatment, prefers medicinal plants, diet, lifestyle (c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology

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