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Refrences partial automated experiment

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Refrences partial automated experiment

  1. 1. ‫רשימה‬ ‫ביב‬ ‫ליוגרפי‬ ‫ת‬ )‫(חלקית‬ ‫להרצאה‬ ‫מיום‬ 26.5.2021 : ‫א‬ ‫על‬ ‫"ניסוי‬ ‫הגנטי‬ ‫לתרכיב‬ ‫הילדים‬ ‫יגיבו‬ ‫איך‬ :‫וטומט‬ ? " ‫מאמרים‬ ‫נבחרים‬ ‫בהרצאה‬ ‫שהוזכרו‬ ‫לעיונכם‬ ‫נלווה‬ ‫טקסט‬ ‫בצירוף‬ , : ‫שקפים‬ 4 - 3 : ‫הבדלים‬ ‫וטרא‬ ‫לפגיעות‬ ‫רלוונטיים‬ ‫אשר‬ ‫למבוגרים‬ ‫ילדים‬ ‫מח‬ ‫בין‬ ‫ופיזיולוגיים‬ ‫אנטומיים‬ ‫ומה‬ : 1. Figaji A. A. et al. (2017) "Anatomical and Physiological Differences between Children and Adults Relevant to Traumatic Brain Injury and the Implications for Clinical Assessment and Care". Frontiers in Neurology, 8:685. :‫ילדים‬ ‫של‬ ‫אנטומיה‬ ‫ה‬ ‫ב‬ ‫בדלים‬ ‫כבד‬ ‫לוואי‬ ‫לתופעות‬ ‫והקשר‬ ‫מבוגרים‬ ‫לעומת‬ ‫ילדים‬ , ‫בה‬ ‫למשל‬ ‫קשר‬ ‫אפילפסיה‬ ‫של‬ ‫תרופות‬ ‫של‬ 2. Anderson G.D. et al. (2002) "Children versus adults: pharmacokinetic and adverse-effect differences". Epilepsia (2002) 43 Suppl 3:53-9. ‫בין‬ ‫ומבוגרים‬ ‫ילדים‬ ‫אצל‬ ‫ובלב‬ ‫במח‬ ‫דם‬ ‫בזרימת‬ ‫גיל‬ ‫תלויי‬ ‫הבדלים‬ :‫ילדים‬ ‫של‬ ‫אנטומיה‬ ) 3-4 ‫(שקפים‬ :‫שנים‬ 61-‫ל‬ ‫חודשים‬ 7 ‫גילאי‬ 3. Wu, C., Honarmand, A. R., et al. (2016). "Age-Related Changes of Normal Cerebral and Cardiac Blood Flow in Children and Adults Aged 7 Months to 61 Years". Journal of the American Heart Association, 5(1), e002657. ‫שקף‬ 5 – ‫עיגודלי‬ :‫מרנ"א‬ ‫של‬ ‫ם‬ ,‫הטכנולוגיה‬ ‫על‬ ,‫העיגולד‬ ‫בניית‬ ‫והסכנות‬ ‫הרעילות‬ 4. Whitehead K. "Lipid Nanoparticles for mRNA vaccine delivery", youtube, "The technology behind the new COVID-19 mRNA vaccines" 18/2/21 https://www.youtube.com/watch?v=lJO51Sguyaw Hongtao Ly. Shubjao Zhang et al. (2006) "Toxicity of Cationic lipids and cationic polymers in gene delivery" ACS Nano Review, Controlled Release Vol: 114, 100−109. 5. Morille M., Passirani C., et al. (2008) "Progress in Developing Cationic Vectors for Non-viral Systemic Gene Therapy against Cancer", Biomaterials, 29, 3477−3496 6. Juszkiewicz K., Sikorski A. et al. (2020) "Building Blocks to Design Liposomal Delivery Systems", Int. J. Mol. Sci. 2020, 21(24), 9559 ‫שקף‬ 6 : ‫ל‬ - 70 ‫מהאוכלוסיה‬ ‫אחוז‬ ‫יש‬ ‫כנג‬ ‫נוגדנים‬ ‫ד‬ PEG ( ‫בסביבת‬ ‫יותר‬ ‫מאוחר‬ ‫גם‬ ‫מופיע‬ ‫הנושא‬ ‫ש‬ ‫קף‬ 20 ) 7. Hoang T. Thi, Pilkington E.H. et al. "The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation"
  2. 2. 8. Zhang P, Sun F, et al. (2016). "Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation". J Control Release (2016) 244(Pt B):184-193. 9. Mohamed M., Abu Lila Amr S. et al. (2019) "PEGylated liposomes: immunological responses", Sci Technol Adv Mater. 2019; 20(1): 710–724. 10. Abu Lila Amr S, Kiwada H. et al. (2013) "The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage", Journal of Controlled Release, Vol 172(1):38-47 ‫וקוגין‬ ‫פגני‬ ‫בשם‬ ‫תרופה‬ ,‫חריפה‬ ‫כלילית‬ ‫תסמונת‬ ‫שק‬ ‫פים‬ 8 - 7 ‫לאן‬ ‫ה‬ ?‫בגוף‬ ‫מגיע‬ ‫חומר‬ ‫מדו"ח‬ ‫ציטטות‬ EMA 11. EMA, Assessment report /707383/2020. p. 47. EMA/707383/2020 Corr, Committee for Medicinal Products for Human Use (CHMP), Assessment report Comirnaty Common name: COVID-19 mRNA vaccine (nucleoside-modified) Procedure No. EMEA/H/C/005735/0000 , page no. 46 of 140 12. EMA, EMA/707383/2020 Corr, Committee for Medicinal Products for Human Use, (CHMP) Assessment report Comirnaty Common name: COVID- 19 mRNA vaccine (nucleoside-modified) Procedure No. EMEA/H/C/005735/0000, (study 185350), page no. 47 of 140 ‫שקף‬ 11 : ‫בין‬ ‫הקשר‬ GGT ‫לסכרת‬ ‫מסוג‬ 2 - ‫ו‬ ‫לגלוקוז‬ ‫סבילות‬ ‫אי‬ 13. Haghighi S, Amini M, et al. (2011) "Relationship between gamma-glutamyl transferase and glucose intolerance in first degree relatives of type 2 diabetics patients". J Res Med Sci, 16(2):123-9. 14. Ortega E., Koska J. et al. (2006) "Serum γ-Glutamyl Transpeptidase Is a Determinant of Insulin Resistance Independently of Adiposity in Pima Indian Children", The Journal of Clinical Endocrinology & Metabolism, 91(4): 1419– 1422 19 ‫קוביד‬ ‫עם‬ ‫מבוגרים‬ ‫אצל‬ ‫יותר‬ ‫ארוכה‬ ‫שהיה‬ ‫מנבא‬ GGT :11 ‫שקף‬ 15. Shao T, Tong Y, et al. (2020),"γ-Glutamyltransferase Elevations Are Frequent in Patients With COVID-19: A Clinical Epidemiologic Study". Hepatology Communications, 4(12):1744–50. ‫שקף‬ 11 : ‫קוביד‬ ‫עם‬ ‫זיהום‬ ‫חומרת‬ ‫שמנבאים‬ ‫פקטורים‬ - 19 – ‫אנזים‬ GGT ‫התפתחות‬ ‫ניבא‬ ‫מחלה‬ ‫יותר‬ ‫קשה‬ 16. Sánchez R., Lepe-Balsalobre R., et al. (2021) "Prognostic factors for the severity of SARS-CoV-2 infection" Advances in Laboratory Medicine (Avances en Medicina de Laboratorio), Published Ahead of Print / Just Accepted ‫שקף‬ 11 : ‫אנזים‬ GGT ‫ילדים‬ ‫במיון‬ ‫ילדים‬ ‫של‬ ‫פרוגנוזה‬ ‫מנבא‬ : 17. Aygun F., Kirkoc R., Aygun D, et al. (2018) "Gamma Glutamyl Transferase and Uric Acid Levels Can Be Associated with the Prognosis of Patients in the Pediatric Intensive Care Unit." Children (Basel) 30; 5(11):147
  3. 3. ‫שקף‬ 11 : GGT ‫כללית‬ ‫אוכלוסייה‬ ‫מבוסס‬ ‫מחקר‬ ‫לפי‬ – ‫הרב‬ ‫עון‬ ‫מנבא‬ ‫שלו‬ ‫העליון‬ ‫בהשתלת‬ ‫צורך‬ ‫להחלפתה‬ ‫התחלתי‬ ‫טיפול‬ ‫או‬/‫ו‬ ‫כליה‬ 18. Lee, D.Y., Han, K., et al. (2020) "Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study". Sci Rep, 10, 11668. ‫שקף‬ 12 : ‫אנזים‬ GGT - ‫קשור‬ ‫בסי‬ ‫לאתרוס‬ ‫כון‬ ‫(גרמניה‬ ‫כלילית‬ ‫לב‬ ‫ומחלת‬ ‫קלרוזה‬ 2018 ) – ‫התרשים‬ ‫מכאן‬ ‫במצגת‬ ‫שתרגמתי‬ 19. Ndrepepa G., Colleran R., et al. (2018) "Gamma-glutamyl transferase and the risk of atherosclerosis and coronary heart disease." Clin Chim Acta (2018) 476:130-138. ‫רעיל‬ ‫מכימיקל‬ ‫מסונתז‬ ‫פג‬ :17 ‫שקף‬ 20. D'souza AA, Shegokar R. (2016)"Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications". Expert Opin Drug Deliv. 13:1257‐1275 21. Hussein S.Z., Belkind G. J. et al. "Probable neuropsychiatric toxicity of polyethylene glycol: roles of media, internet and the caregivers", GastroHep, ‫שקפים‬ 16 - 13 : ‫שעס‬ ‫מהמאמרים‬ ‫מקצת‬ ‫ב‬ ‫קו‬ ‫רעילות‬ ‫ו‬ ‫של‬ ‫אימונוגניות‬ ‫נשיאה‬ ‫מערכות‬ - ‫מיצלות‬ - ‫פגילציה‬ ‫שעברו‬ ‫תופעת‬ ‫ועל‬ ABC ‫על‬ ‫מדברת‬ ‫אבל‬ ‫במצגת‬ ‫עליה‬ ‫פירטתי‬ ‫(שפחות‬ ‫הצט‬ ‫ברות‬ ‫רעילה‬ )‫מהדם‬ ‫מהיר‬ ‫פינוי‬ ‫בגלל‬ 22. Shiraishi K, Yokoyama M. et al. (2019) "Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review" Sci Technol Adv Mater. 2019; 20(1): 324–336. 23. The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to 24. Onoue S., Yamada S. wt al. (2014) "Nanodrugs: pharmacokinetics and safety", Int J Nanomedicine. 2014; 9: 1025–1037 ‫שקפים‬ 31 - 17 : 25. Rose, J. PhD, MSc, BSc. "Potential dangers associated with COVID-19 injectable products", a letter to Dr. Simone Gold, May 8, 2021 https://www.slideshare.net/enave2609/letter-for-simone-goldjessica-rose 26. Rose J. "VAERS report for VCC", 4/5/21 https://www.youtube.com/watch?v=CfeiZzXcjNw 27. Blétry O, Piette AM. (1997) "Recurrent fetal loss and antiphospholipid antibodies: clinical and therapeutic aspects". Infect Dis Obstet Gynecol, 5(2):183-191 28. A Study of the Potential for Polyethylene Glycol (Miralax) to Metabolize into Toxic Oxalate - ‫דם‬ ‫וקרישי‬ ‫תרומבוטיים‬ ‫אירועים‬ – ‫גוצקו‬ ‫ג'וש‬ ‫ד"ר‬ ‫מצגות‬ 29. https://drive.google.com/file/d/1wLCnMibfoEcX9GDBN_rHNRodK5E5cr Oe/view?usp=sharing
  4. 4. 30. https://www.slideshare.net/enave2609/reports-of-blood-clot-related- adverse-events-may-23-josh-g 31. https://www.slideshare.net/enave2609/reports-of-blood-clot-related- adverse-events-ipc-may-23 ‫שקפי‬ 20 :+ ‫מוד‬ ‫(בחיסון‬ ‫בדם‬ ‫משוטטות‬ ‫הספייק‬ ‫של‬ ‫חתיכות‬ ‫רנ‬ ‫ה‬ :) 32. Ogata A.F., Cheng C.A., et al. (2021)"Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients", Clinical Infectious Diseases (2021) ‫חלבון‬ S 1 ‫מג‬ :‫למח‬ ‫יע‬ 33. Rhea, E.M., Logsdon, A.F., Hansen, K.M. et al. The S1 protein of SARS-CoV- 2 crosses the blood–brain barrier in mice. Nat Neurosci (2021) 24, 368–378 ‫מ‬ ‫שעבר‬ ‫מרנ"א‬ ‫תרכיבי‬ ‫של‬ ‫רעילות‬ ‫ודיפיקציה‬ 34. Jeonghwan K., Eygeris Y. et al. (2021) "Self assembled mRNA vaccines", Adv Drug Deliv Rev., 170: 83–112 35. Andries O., Mc Cafferty S. et al. (2015) "N(1)-methylpseudouridine- incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice", J. Control Release 10;217:337-44 36. McKenzie R., W. Fried M., et al. (1995) "Hepatic Failure and Lactic Acidosis Due to Fialuridine (FIAU), an Investigational Nucleoside Analogue for Chronic Hepatitis B", N Engl J Med 1995; 333:1099-1105 :‫מחדש‬ ‫החיסון‬ ‫מערכת‬ ‫תכנות‬ 37. Research suggests that Pfizer-Biontech Covid-19 vaccined reporograms innate immune responses : ‫וגינליים‬ ‫דימומים‬ 38. Thrombosis after covid-19 vaccination BMJ 2021; 373 (Published 14 April 2021)Cite this as: BMJ 2021;373:n958 https://www.bmj.com/content/373/bmj.n958/rr-2 ‫ועמיתים‬ ‫יאנג‬ 2016 ‫ששמו‬ ‫אחר‬ ‫ממחקר‬ ‫כציטוט‬ ‫לקחנו‬ : The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation Thai Thanh Hoang Thi 1 , Emily H. Pilkington 2 , Dai Hai Nguyen 3,4 , Jung Seok Lee 5 , Ki Dong Park 6 and Nghia P. Truong 2 , *

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