Dhananjay TR35 Award Final

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Dhananjay TR35 Award Final

  1. 1. Point-of-care medical diagnostics for improved healthcare outcomes Emtech India 2010 Conference, Bangalore Dhananjaya Dendukuri, CEO & Co-Founder, Achira Labs Pvt. Ltd. 03/18/10
  2. 2. Background & Motivation <ul><ul><li>The problem of inaccessible medical Dx </li></ul></ul><ul><ul><ul><li>High costs and infrastructure needed </li></ul></ul></ul><ul><ul><ul><li>Centralized testing </li></ul></ul></ul><ul><ul><ul><li>Correlation of results </li></ul></ul></ul><ul><ul><ul><li>Drug resistant strains </li></ul></ul></ul><ul><ul><ul><li>Spread of epidemics </li></ul></ul></ul><ul><ul><li>The solution - (POC) tests </li></ul></ul><ul><ul><ul><li>Faster, simpler, cheaper </li></ul></ul></ul><ul><ul><ul><li>Multiplexed, sensitive, automated and integrated </li></ul></ul></ul>Yager et al., Ann. Rev. Biomed. Eng. 2008 Microfluidics – a tool for sample processing and fluid manipulation Disease Annual Deaths HIV 2.9 million TB 1.6 million Malaria 2 million Other IDs > 2 million
  3. 3. Chip <ul><ul><li>Microchannel architecture - fabrication enabled by IC technologies. Reagent storage on chip simplifies testing </li></ul></ul><ul><ul><li>Multiplexing – novel IP enabled manufacturing methods for chip loading with multiple reagents (patents filed) </li></ul></ul><ul><ul><li>High sensitivity - enabled by newly engineered materials and sensitivity </li></ul></ul>03/18/10 b 0.1 mm Dendukuri et al, Lab Chip (2007)                                                                                                                                                                 Test 1   Test 2   Test 3   Test 4
  4. 4. Reader <ul><li>Characteristics </li></ul><ul><li>Highly sensitive optical detection techniques - sub nM sensitivity </li></ul><ul><li>Optimized internal electronics for high signal-to-noise ratio measurements </li></ul><ul><li>Automated with fluid control algorithms </li></ul><ul><li>Future Plans </li></ul><ul><li>Field testing on protein panels over the next 12 months </li></ul><ul><li>Commercial Release 2012 </li></ul>03/18/10 2.2nM
  5. 5. Acknowledgements <ul><li>Achira Labs is part of Group Lifespring </li></ul><ul><li>Investors – Nadathur </li></ul><ul><li>Chairman, Achira Labs – Suri Venkatachalam </li></ul><ul><li>Connexios Life Sciences </li></ul><ul><li>Advisors at MIT – Patrick S. Doyle & T. Alan Hatton </li></ul><ul><li>Team at Achira Labs </li></ul><ul><li>www.achiralabs.com </li></ul>03/18/10

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