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PET-Positron Emission Tomography
What Is PET?• Nuclear medicine scan, Functional imaging  technique.• Quantifiable – amount of radiation depends on  rate o...
How Does PET Work?• Administration of radiopharmacon• Decay of isotope internally, accumulation ofradiopharmacon in diseas...
Detection Of Emission
Collection Of Data – Lines Of                  Conicidence                            Linear sampling – defining          ...
Radioactive Isotopes                Common isotopes used for PET examinations and their main                              ...
Medical Fields Of Application• PET and PET/CT scans are performed to:• detect cancer.• determine spread of cancer• Determi...
Medical Fields Of Application
PET Image Fusion Technique    •Fusion of a PET scan with MRI, CT or alternative image        to give functional and anatom...
CT scan
PET scan
Fused PET and CT image
Benefits And Risks Of PET Benefits of PET: •Image information unique- high sensitivity •yields most useful information com...
Pet presentation, positron emission tomography
Pet presentation, positron emission tomography
Pet presentation, positron emission tomography
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Pet presentation, positron emission tomography

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Pet presentation, positron emission tomography

  1. 1. PET-Positron Emission Tomography
  2. 2. What Is PET?• Nuclear medicine scan, Functional imaging technique.• Quantifiable – amount of radiation depends on rate of metabolic activity• non-invasive, but does involves exposure to ionizing radiation,• Usage of radioactive isotopes (radiopharmacons) emitt β⁺ particles
  3. 3. How Does PET Work?• Administration of radiopharmacon• Decay of isotope internally, accumulation ofradiopharmacon in diseased tissue.• Electron interaction  annihilation emission of 2 gamma photons.• Scintillating detectors ( gamma camera).• Collection and storage of data  reconstructionof 2D distribution map.• Most scans today are combined with CT.
  4. 4. Detection Of Emission
  5. 5. Collection Of Data – Lines Of Conicidence Linear sampling – defining parallel coincidence sampling paths.Each detector can beoperated in multiplecoincidence with manydetectors across from it.
  6. 6. Radioactive Isotopes Common isotopes used for PET examinations and their main propertiesIsotope 11 C 13 N 15 O 18 FHalf-life (minutes) 20.3 9.98 2.05 110Nuclear reaction 14 N (p,α) 11C 16 O(p,α) 13N 14 N(d,n) 15O 18 O (p,n) 18F Manifactured by cyclotrons. Cyclotron = accelerator with a circular path enforced by a magnetic field.
  7. 7. Medical Fields Of Application• PET and PET/CT scans are performed to:• detect cancer.• determine spread of cancer• Determine effectiveness of treatment, such as cancer therapy.• Detect return of a cancer.• determine blood flow to the heart muscle.• determine the effects of a heart attack, or myocardial infarction, on areas of the heart.• Identification whether certain areas of the hear would or wouldn’t benefit from surgery.• Evaluate brain abnormalities; tumors, memory disorders, seizures and other central nervous system disorders.• To map normal human brain and heart function.
  8. 8. Medical Fields Of Application
  9. 9. PET Image Fusion Technique •Fusion of a PET scan with MRI, CT or alternative image to give functional and anatomical information.
  10. 10. CT scan
  11. 11. PET scan
  12. 12. Fused PET and CT image
  13. 13. Benefits And Risks Of PET Benefits of PET: •Image information unique- high sensitivity •yields most useful information compared to other imaging techniques from a pathological view. •High spatial resolution • more precise, cheaper, and more esthetical than exploratory surgery. •Can detect a disease at an earlier stage than ex. CT scans or MRI. •Result in low radiation exposure. (obs. not more than any other type of imaging method!)Risks with PET:•Allergic reactions to radiopharmaceuticals may occur but are rare.•Injection of the radiotracer may cause slight pain and redness which shouldrapidly resolve.•Expensive – due to cyclotrons needed to produce short lived radionuclides.•Low accecssbility• takes time

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