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Saturday, July 23, 2011
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Clasificación Internacional de la
                 Retinopatía del Prematuro




                          Dr. Pedro R Mattar Neri
                           Medico Oftalmólogo

Saturday, July 23, 2011
Es una enfermedad vasoproliferativa de la retina de etiología
         multifactorial que ocurre en el niño prematuro




Saturday, July 23, 2011
Universo de la ROP
                                                                         VASCULARIZACION MADURA
                                                                 L
                                                             RMA
                                                        NO
                                                   ON
                                                 CI
                                             RI
                                               ZA                                                        90%
                                                                                                      85-
                                        U LA                                                      N
                                   SC                                                        IO
                                VA                                                         ES
                                                                                         GR
                                                                                    RE



                                                                                      PRO
                                                                                          G   RE
                           RETRASO                                                                SIO
                                                                                                  DR N
                    16 semana                                          ROP ACTIVA

                                                                     SEMANAS

         Pathogenesis of retinopathy of prematurity L E.H. Smitth Growth Hormone & IGF Research
         14 (2004) S140–S144
         Antivascularendothelial growthfactor for retinopathy of prematurity H.A. Mintz-Hittnera et al.
         CurrentOpinioninPediatrics2009, 21:182–187



Saturday, July 23, 2011
Universo de la ROP
                                                                   VASCULARIZACION MADURA
                                                           L
                                                       RMA
                                                  NO
                                             ON
                                           CI
                                       RI
                                         ZA                                                           90%
                                                                                                   85-
                                  U LA                                                         N
                                  SC                                                      IO
                                VA VASCULOGENESESIS                                     ES
                                                                                      GR
                                                                                 RE
                                FASE I (UTERO HIPOXIA
                                    FISIOLOGICA)
                                         22 - 30 S
                                                                                    PRO
                                                                                        G  RE
                           RETRASO                                                             SIO
                                                                                               DR N
                    16 semana                                    ROP ACTIVA

                                                               SEMANAS

         Pathogenesis of retinopathy of prematurity L E.H. Smitth Growth Hormone & IGF Research
         14 (2004) S140–S144
         Antivascularendothelial growthfactor for retinopathy of prematurity H.A. Mintz-Hittnera et al.
         CurrentOpinioninPediatrics2009, 21:182–187



Saturday, July 23, 2011
Universo de la ROP




                                                                       OX IN O
                                                                     ER M T
                                                                         IA O
                                                                   IP ER EN
                                                                   VASCULARIZACION MADURA




                                                                           )
                                                           L
                                                        MA




                                                                 (H ET IMI
                                                       R
                                                  NO
                                             ON
                                           CI




                                                                  PR AC
                                       RI
                                         ZA                                                           90%
                                                                                                   85-
                                    LA




                                                                    N
                                  U                                                            N
                                  SC                                                      IO
                                VA VASCULOGENESESIS                                     ES
                                                                                      GR
                                                                                 RE
                                FASE I (UTERO HIPOXIA
                                    FISIOLOGICA)
                                         22 - 30 S
                                                                                    PRO
                                                                                        G  RE
                           RETRASO                                                             SIO
                                                                                               DR N
                    16 semana                                    ROP ACTIVA

                                                               SEMANAS

         Pathogenesis of retinopathy of prematurity L E.H. Smitth Growth Hormone & IGF Research
         14 (2004) S140–S144
         Antivascularendothelial growthfactor for retinopathy of prematurity H.A. Mintz-Hittnera et al.
         CurrentOpinioninPediatrics2009, 21:182–187



Saturday, July 23, 2011
Universo de la ROP




                                                                       OX IN O
                                                                     ER M T
                                                                         IA O
                                                                   IP ER EN
                                                                   VASCULARIZACION MADURA




                                                                           )
                                                           L
                                                        MA




                                                                 (H ET IMI
                                                       R
                                                  NO
                                             ON
                                           CI




                                                                  PR AC
                                       RI
                                         ZA                                                           90%
                                                                                                   85-
                                    LA




                                                                    N
                                  U                                                            N
                                  SC                                                      IO
                                VA VASCULOGENESESIS                                     ES
                                                                                      GR
                                                                                 RE
                                FASE I (UTERO HIPOXIA
                                    FISIOLOGICA)                            ANGIOGENESIS
                                         22 - 30 S                       (NEOV. PATOLOGICA)
                                                                                PRO
                           RETRASO                                         FASE II (HIPOXIA)
                                                                                    GR
                                                                                       ESI
                                                                                           O
                                                                                31 - 45DR N
                                                                                         S
                    16 semana                                    ROP ACTIVA

                                                               SEMANAS

         Pathogenesis of retinopathy of prematurity L E.H. Smitth Growth Hormone & IGF Research
         14 (2004) S140–S144
         Antivascularendothelial growthfactor for retinopathy of prematurity H.A. Mintz-Hittnera et al.
         CurrentOpinioninPediatrics2009, 21:182–187



Saturday, July 23, 2011
Retinopatía del Prematuro




           “ROP es una enfermedad de las Unidades de
            Neonatologia y hay que buscarlas en ellas”
                                    J.C. Serrano
Saturday, July 23, 2011
Retinopatía del Prematuro




           “ROP es una enfermedad de las Unidades de
            Neonatologia y hay que buscarlas en ellas”
                                    J.C. Serrano
Saturday, July 23, 2011
Retinopatía del Prematuro


                                               “ROP
                                       EN EL CONSULTORIO”




Saturday, July 23, 2011
The International Classification of Retinopathy
             of Prematurity (ICROP) 1981-1984
    •     1981 Ross Laboratories ROP symp.


              •     23 Oftalmologos


              •     11 Paises


    •     Calgary, Alberta, Canada - Sept 1982


    •     Bethesda, Maryland - Sept 1983


    •     Arch Ophthalmol 1984;102:1130-1134


    •     San Francisco, California – 1985 – Further Classification of RD


    •     Arch Ophthalmol 1987;105:906-912

Saturday, July 23, 2011
ICROP- Revisited
               Canada - Anna Ells, MD (Co-chair)
             United Kingdom - Alistair Fielder, MD
             United States -Antonio Capone, Jr., MD
                           John Flynn, MD
                         William Good, MD,
                        Jonathan Holmes, MD
                         Arch McNamara, MD
                           Earl Palmer, MD
                     Graham Quinn, MD, MSCE
                            (Co-chair)
                        Michael Shapiro, MD
                         Michael Trese, MD
                         David Wallace, MD
                   Australia - Glen Gole, MD
              Sweden - Gerd Holmstrom, MD, PhD ICROP. Arch Ophthalmol.102: 1984
               Latin America - Ximena Katz, MD ICROP.R; Arch Ophthalmol.123: 2005


Saturday, July 23, 2011
Principio Básico del ICROP-R

            “Mientras mas posterior es la
             enfermedad, mas retina esta
               afectada, mas seria es la
                     enfermedad”

                          ICROP.R; Arch Ophthalmol.123: 2005


Saturday, July 23, 2011
CLASIFICACION ROP
                        Localización: Zonas
                     Extensión: Horas (Reloj)
                             Severidad:
                            Estadios 1-5
                Aggressive Posterior ROP (AP-ROP)
                     Plus (+) disease/Pre-plus

                               ICROP. Arch Ophthalmol.102: 1984
                              ICROP.R; Arch Ophthalmol.123: 2005

Saturday, July 23, 2011
Progresión ROP




                            Anna Ells M.D. cortesia Graham Quinn M.D.
Saturday, July 23, 2011
LOCALIZACION
      • Zona I      (polo
            posterior)
      • Zona II     (Ora
            Serrata Nasal)
      • Zona III (Ora
            Serrata
            Temporal)

                                         ICROP
Saturday, July 23, 2011
Zona 1




               Cortesía W. Tasman
                                    Cortesía Dr. Gonzalez

Saturday, July 23, 2011
EXTENSION
                          EXTENSION




                                      ICROP
Saturday, July 23, 2011
SEVERIDAD

      •     Inmadura - Sin ROP

      •     Estadio 1 – Linea Demarcación

      •     Estadio 2 – Pliegue

      •     Estadio 3 – Neovascularización Extraretinal desde el
            área del pliegue

      •     Estadio 4 – Desprendimiento parcial de Retina

      •     Estadio 5 – Desprendimiento Total de Retina

Saturday, July 23, 2011
Vascularizacion Inmadura




                          Cortesía G. Quinn

Saturday, July 23, 2011
Fetal Fundus




                               CA 46 days, AA 30 6/7 weeks

                          OD                                   OS


                                           Cortesía G. Quinn

Saturday, July 23, 2011
ESTADIO 1
                          (Línea de Demarcación)




                                                   ICROP
Saturday, July 23, 2011
ESTADIO 2
                          (Cresta o pliegue +/- Proliferación)




                                                                 ICROP
Saturday, July 23, 2011
ESTADIO 3 (+)
               (Cresta o pliegue +/- Proliferación Extraretinal)




                                                            ICROP
Saturday, July 23, 2011
Progresion ROP




                          Anna Ells M.D. cortesia Graham Quinn M.D.
Saturday, July 23, 2011
ESTADIO 4A (DR Subtotal)
                                Extrafoveal




                                                     ICROP
Saturday, July 23, 2011
ESTADIO 4B (DR Subtotal)
                                  Fovea




                                                     ICROP
Saturday, July 23, 2011
ESTADIO 5
                           (DR Total)




                                        ICROP
Saturday, July 23, 2011
Aggressive Posterior
                          ROP

   • Forma mas Severa, de progresion
     rapida
   • Retinopatia Virulenta
   • Localizacion Posterior
   • Agresiva enfermedad Plus

                                       ICROP-R
Saturday, July 23, 2011
Indicadores de Severidad
       PLUS (+)
          •
          Moderada tortuosidad y dilatación
          Vasos Polo Posterior en presencia de
          ROP
          •
          Vasos del Iris ingurgitados
          •
          Poca Dilatacion Pupilar



                                          ICROP
Saturday, July 23, 2011
Cuanta Tortuosidad es Plus ?
                             Fotografia Standard




   Define la minima dilatacion y tortuosisdad vascular para
    Enf. Plus




     ETROP, Pediatrics 2005                 CRYO-ROP, Arch Ophth 1988

Saturday, July 23, 2011
ICROP, Arch Ophth
            1984

                                 Plus disease



  CRYO-ROP, Arch Ophth 1988




                              ETROP, Pediatrics 2005

Saturday, July 23, 2011
Enfermedad Pre-Plus
      Dilatacion insuficiente para Plus, que puede
                       progresar




                                          ICROP-R
Saturday, July 23, 2011
Plus o Pre-Plus?




                                             ICROP-R
Saturday, July 23, 2011
Seré un
                           Ciego




Saturday, July 23, 2011
O duermo
                          tranquilo

Saturday, July 23, 2011
Gracias al cuidado
                                 neonatal este bebe no
                                      tiene ROP
                          Text




Saturday, July 23, 2011
ESTADIO 4




                          Anna Ells M.D. cortesia Graham Quinn M.D.
Saturday, July 23, 2011

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Classification of Retinopathy of Prematurity

  • 9. Clasificación Internacional de la Retinopatía del Prematuro Dr. Pedro R Mattar Neri Medico Oftalmólogo Saturday, July 23, 2011
  • 10. Es una enfermedad vasoproliferativa de la retina de etiología multifactorial que ocurre en el niño prematuro Saturday, July 23, 2011
  • 11. Universo de la ROP VASCULARIZACION MADURA L RMA NO ON CI RI ZA 90% 85- U LA N SC IO VA ES GR RE PRO G RE RETRASO SIO DR N 16 semana ROP ACTIVA SEMANAS Pathogenesis of retinopathy of prematurity L E.H. Smitth Growth Hormone & IGF Research 14 (2004) S140–S144 Antivascularendothelial growthfactor for retinopathy of prematurity H.A. Mintz-Hittnera et al. CurrentOpinioninPediatrics2009, 21:182–187 Saturday, July 23, 2011
  • 12. Universo de la ROP VASCULARIZACION MADURA L RMA NO ON CI RI ZA 90% 85- U LA N SC IO VA VASCULOGENESESIS ES GR RE FASE I (UTERO HIPOXIA FISIOLOGICA) 22 - 30 S PRO G RE RETRASO SIO DR N 16 semana ROP ACTIVA SEMANAS Pathogenesis of retinopathy of prematurity L E.H. Smitth Growth Hormone & IGF Research 14 (2004) S140–S144 Antivascularendothelial growthfactor for retinopathy of prematurity H.A. Mintz-Hittnera et al. CurrentOpinioninPediatrics2009, 21:182–187 Saturday, July 23, 2011
  • 13. Universo de la ROP OX IN O ER M T IA O IP ER EN VASCULARIZACION MADURA ) L MA (H ET IMI R NO ON CI PR AC RI ZA 90% 85- LA N U N SC IO VA VASCULOGENESESIS ES GR RE FASE I (UTERO HIPOXIA FISIOLOGICA) 22 - 30 S PRO G RE RETRASO SIO DR N 16 semana ROP ACTIVA SEMANAS Pathogenesis of retinopathy of prematurity L E.H. Smitth Growth Hormone & IGF Research 14 (2004) S140–S144 Antivascularendothelial growthfactor for retinopathy of prematurity H.A. Mintz-Hittnera et al. CurrentOpinioninPediatrics2009, 21:182–187 Saturday, July 23, 2011
  • 14. Universo de la ROP OX IN O ER M T IA O IP ER EN VASCULARIZACION MADURA ) L MA (H ET IMI R NO ON CI PR AC RI ZA 90% 85- LA N U N SC IO VA VASCULOGENESESIS ES GR RE FASE I (UTERO HIPOXIA FISIOLOGICA) ANGIOGENESIS 22 - 30 S (NEOV. PATOLOGICA) PRO RETRASO FASE II (HIPOXIA) GR ESI O 31 - 45DR N S 16 semana ROP ACTIVA SEMANAS Pathogenesis of retinopathy of prematurity L E.H. Smitth Growth Hormone & IGF Research 14 (2004) S140–S144 Antivascularendothelial growthfactor for retinopathy of prematurity H.A. Mintz-Hittnera et al. CurrentOpinioninPediatrics2009, 21:182–187 Saturday, July 23, 2011
  • 15. Retinopatía del Prematuro “ROP es una enfermedad de las Unidades de Neonatologia y hay que buscarlas en ellas” J.C. Serrano Saturday, July 23, 2011
  • 16. Retinopatía del Prematuro “ROP es una enfermedad de las Unidades de Neonatologia y hay que buscarlas en ellas” J.C. Serrano Saturday, July 23, 2011
  • 17. Retinopatía del Prematuro “ROP EN EL CONSULTORIO” Saturday, July 23, 2011
  • 18. The International Classification of Retinopathy of Prematurity (ICROP) 1981-1984 • 1981 Ross Laboratories ROP symp. • 23 Oftalmologos • 11 Paises • Calgary, Alberta, Canada - Sept 1982 • Bethesda, Maryland - Sept 1983 • Arch Ophthalmol 1984;102:1130-1134 • San Francisco, California – 1985 – Further Classification of RD • Arch Ophthalmol 1987;105:906-912 Saturday, July 23, 2011
  • 19. ICROP- Revisited Canada - Anna Ells, MD (Co-chair) United Kingdom - Alistair Fielder, MD United States -Antonio Capone, Jr., MD John Flynn, MD William Good, MD, Jonathan Holmes, MD Arch McNamara, MD Earl Palmer, MD Graham Quinn, MD, MSCE (Co-chair) Michael Shapiro, MD Michael Trese, MD David Wallace, MD Australia - Glen Gole, MD Sweden - Gerd Holmstrom, MD, PhD ICROP. Arch Ophthalmol.102: 1984 Latin America - Ximena Katz, MD ICROP.R; Arch Ophthalmol.123: 2005 Saturday, July 23, 2011
  • 20. Principio Básico del ICROP-R “Mientras mas posterior es la enfermedad, mas retina esta afectada, mas seria es la enfermedad” ICROP.R; Arch Ophthalmol.123: 2005 Saturday, July 23, 2011
  • 21. CLASIFICACION ROP Localización: Zonas Extensión: Horas (Reloj) Severidad: Estadios 1-5 Aggressive Posterior ROP (AP-ROP) Plus (+) disease/Pre-plus ICROP. Arch Ophthalmol.102: 1984 ICROP.R; Arch Ophthalmol.123: 2005 Saturday, July 23, 2011
  • 22. Progresión ROP Anna Ells M.D. cortesia Graham Quinn M.D. Saturday, July 23, 2011
  • 23. LOCALIZACION • Zona I (polo posterior) • Zona II (Ora Serrata Nasal) • Zona III (Ora Serrata Temporal) ICROP Saturday, July 23, 2011
  • 24. Zona 1 Cortesía W. Tasman Cortesía Dr. Gonzalez Saturday, July 23, 2011
  • 25. EXTENSION EXTENSION ICROP Saturday, July 23, 2011
  • 26. SEVERIDAD • Inmadura - Sin ROP • Estadio 1 – Linea Demarcación • Estadio 2 – Pliegue • Estadio 3 – Neovascularización Extraretinal desde el área del pliegue • Estadio 4 – Desprendimiento parcial de Retina • Estadio 5 – Desprendimiento Total de Retina Saturday, July 23, 2011
  • 27. Vascularizacion Inmadura Cortesía G. Quinn Saturday, July 23, 2011
  • 28. Fetal Fundus CA 46 days, AA 30 6/7 weeks OD OS Cortesía G. Quinn Saturday, July 23, 2011
  • 29. ESTADIO 1 (Línea de Demarcación) ICROP Saturday, July 23, 2011
  • 30. ESTADIO 2 (Cresta o pliegue +/- Proliferación) ICROP Saturday, July 23, 2011
  • 31. ESTADIO 3 (+) (Cresta o pliegue +/- Proliferación Extraretinal) ICROP Saturday, July 23, 2011
  • 32. Progresion ROP Anna Ells M.D. cortesia Graham Quinn M.D. Saturday, July 23, 2011
  • 33. ESTADIO 4A (DR Subtotal) Extrafoveal ICROP Saturday, July 23, 2011
  • 34. ESTADIO 4B (DR Subtotal) Fovea ICROP Saturday, July 23, 2011
  • 35. ESTADIO 5 (DR Total) ICROP Saturday, July 23, 2011
  • 36. Aggressive Posterior ROP • Forma mas Severa, de progresion rapida • Retinopatia Virulenta • Localizacion Posterior • Agresiva enfermedad Plus ICROP-R Saturday, July 23, 2011
  • 37. Indicadores de Severidad PLUS (+) • Moderada tortuosidad y dilatación Vasos Polo Posterior en presencia de ROP • Vasos del Iris ingurgitados • Poca Dilatacion Pupilar ICROP Saturday, July 23, 2011
  • 38. Cuanta Tortuosidad es Plus ? Fotografia Standard Define la minima dilatacion y tortuosisdad vascular para Enf. Plus ETROP, Pediatrics 2005 CRYO-ROP, Arch Ophth 1988 Saturday, July 23, 2011
  • 39. ICROP, Arch Ophth 1984 Plus disease CRYO-ROP, Arch Ophth 1988 ETROP, Pediatrics 2005 Saturday, July 23, 2011
  • 40. Enfermedad Pre-Plus Dilatacion insuficiente para Plus, que puede progresar ICROP-R Saturday, July 23, 2011
  • 41. Plus o Pre-Plus? ICROP-R Saturday, July 23, 2011
  • 42. Seré un Ciego Saturday, July 23, 2011
  • 43. O duermo tranquilo Saturday, July 23, 2011
  • 44. Gracias al cuidado neonatal este bebe no tiene ROP Text Saturday, July 23, 2011
  • 45. ESTADIO 4 Anna Ells M.D. cortesia Graham Quinn M.D. Saturday, July 23, 2011