Petiveria alliacea L. Extract for the Treatment ofGastroesophageal Reflux Disease Edwin J. Alvarado
Petiveria alliacea L.• Petiveria alliacea L., also known as Anamú or garlic weed, is a very influential plant in traditional medicine.• Proved to possess antibacterial1 and analgesic2 properties, among others.• Both contribute to the plant’s reputation for calming GERD symptoms.
Question/Problem• Can the extract from the Petiveria alliacea L. affect the stomach’s pH or, more ideally, the stomach’s acid irrigation?
Hypothesis• If the contents of the stomach are irrigated with the plant’s extract, the pH levels of the acid will increase, inhibiting the stomach’s acid irrigation over a long term exposition, sparing damage to the organs involved.
Chemical Experiment• Prepare a solution of HCl, KCl and NaCl, among others, add consecutive doses of extract and record pH.• To determine if extract acts as a buffer solution.• If true, determine buffer region.
In Vivo Experiment• Organism: Mice / Rats• Quantity: 20 per group (80 in total)• Variables:Presence of extract in ingestion Presence of acid promoters Prowess over time• Period: 4 weeks
Experimental Groups • Group A • P. alliacea extract • No acid promoter foods
Control Group• Group D (NEGATIVE CONTROL) • No P. alliacea extract • No acid promoter foods
Methodology• Strict, standardized diets, varying only aforementioned factors.• After each week, collect five specimens from each group and extract stomach contents.• Analyze pH, acid concentration, gastric component concentration.• Interpret results.
Objectives• To determine if the extract “neutralizes” the stomach’s pH and in what capacity.• To determine if the extract affects the stomach’s acid irrigation and in what capacity.• To determine efficiency, if any, in abnormal stomach conditions.• To determine the efficiency, if any, of short term treatment versus long term.
Goal• Provide those afflicted with GERD an alternative treatment that both relieves pain and controls the disease
References1. Kim S, Kubic R, Musah RA. Antibacterial and antifungal activity of sulfur-containing compounds from Petiveria Alliacea L. 2005. Available from: http://www.sciencedirect.com. Accessed: 2012 June 21.2. Lopes-Martins RAB, Pegoraro DH, Woisky R, Penna SC, Sertié JAA. The anti-Inflammatory and analgesic effects of a crude extract of Petiveria Alliacea L. (Phytolaccaceae). 2004. Available from: http://www.sciencedirect.com. Accessed: 2012 June 21.