The main problem while adopting Agile Methodologies is related to the Cultural Change. Imagine this happening in teams that work together with other teams, with different management strategies and different software development lifecycles. Different projects will be presented. With all these different scenarios, we will focus to understand challenges, actions taken and their results, success situations and failure situations transformed into lessons learned in this Agile adoption path. It’s a presentation to share a research work being developed for almost two years now, with some teams, and share lessons learned about applying Agile Methodologies inside a Global Company.