Oxytocin increasesHRV and protectsagainst socialisolation.
Oxytocin and HRV in animals Grippo et al., (2009). Psychoneuroendochronology 34 (10)
Oxytocin nasal sprayincreases HRV in humans. Kemp, Quintana, Guastella et al., (2012) PLoS One
Almost 10% of Backgroundglobal diseaseburden has beenattributed toalcohol.Rehm et al., (2009) Lancet, 373 3
BackgroundAlmost 60% ofpatients relapse a Almost 60% of patients relapseyear after a year aftercommencing commencing treatment fortreatment. alcohol dependenceIlgen et al., (2008) Drug and Alcoholdependence, 92 3
BackgroundAlcohol is highly accessible for outpatients
HRV is an index ofinhibitory processesand is also related tocognitive flexibility. Thayer & Lane (2000)
We hypothesized Backgroundthat HRV wouldAlmost 60% ofpredict craving patients relapse a year afterseverity. commencing treatment for alcohol dependence 3
We have almostcompleted oxytocintreatment trials onautism, first episodepsychosis, andschizophrenia.
Oxytocin treatment Backgroundtrial for alcohol Almost 60% ofdependence. patients relapse a year after commencing treatment for alcohol dependence 3
Discussion• Oxytocin may ‘break the loop’ of repetitive behaviors related to drug taking (McGregor & Bowen, 2012)• Placebo controlled, between-subjects design (n = 30).• Participants received oxytocin or placebo for 4 weeks.• Pre and post measures include alcohol intake, social cognition and psychophysiology.• 4 week follow-up after treatment completion.
Oxytocin showspromise in thetreatment of disorderscharacterized by poorsocial functioning dueto its influence onautonomic function.
Acknowledgements Dr. Andrew Kemp A/Prof. Adam Guastella Prof. Iain McGregorSCAN research and teaching unit BMRI School of Psychology School of Psychology University of Sydney University of Sydney University of Sydney Prof. Gin Malhi Prof. Ian Hickie Dr. Maree Abbott Gail Alvares James Heathers Cristina Caccioti-Saija Tim Outhred Ruth Wells John Chalmers CJ Yatawara 17
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