Oxytocin andheart ratevariability: A rolein social behaviorand psychiatricillnessDaniel S. Quintana, PhD CandidateSCAN res...
Oxytocin hastraditionally beenassociated withuterine contractionand the milk let-down reflex.               Dale (1906); O...
BackgroundOT studies on social cognition                     4x                  increase     1992-2002      2002-2012
Oxytocinincreasesgaze tothe eyeregion.Guastella et al.,(2008) BiologicalPsychiatry, 63(1).
Oxytocin is acardiovascularhormone.Gutkowska & Janowski (2012) Journalof Neuroendocrinology, 24(4).
BackgroundGutkowska et al., (2007) Am J Physiol,24(4).
The regulation of theautonomic nervoussystem plays a crucialrole in social behavior.Porges (1998)
The autonomic nervous system         The vagus         nerve is part of         a system that         communicates        ...
The autonomic nervous system     Sinoatrial node
Autonomic nervoussystem activity can beindexed by heart ratevariability (HRV).Berntson et al. (1997)
The autonomic nervous systemHRV is the temporal variation of beats
Why is high variability   ‘good’?
The autonomic nervous systemA kr. 2500 NOKPolar heartrate monitor isas good as akr. 90,000 NOKECG system tomeasure HRV.   ...
HRV is                            The autonomic nervous systemreduced indepressionKemp, Quintana et al., (2010) Biological...
Is HRV reduced in MDD?*P > 0.01            Kemp, Quintana et al., (2012) PLoS One
Is HRV reduced in MDD with comorbid anxiety?        *P > 0.01                    Kemp, Quintana et al., (2012) PLoS One
HRV is reduced inalcoholdependence             Quintana, Guastella, Kemp et al., (in               press) Alcoholism: Expe...
The autonomic nervoussystem regulates theprojection and theperception of emotion.
Polyvagal theory and social behavior         Facial         muscles     Laryngeal &Porges (2007) Biological     Pharyngeal...
What is this manthinking or feeling?
HRV is related toemotion recognition.
Oxytocin increasesHRV and protectsagainst socialisolation.
Oxytocin and HRV in animals      Grippo et al., (2009). Psychoneuroendochronology 34 (10)
Oxytocin nasal sprayincreases HRV in humans.               Kemp, Quintana, Guastella et al., (2012) PLoS One
Almost 10% of Backgroundglobal diseaseburden has beenattributed toalcohol.Rehm et al., (2009) Lancet, 373                 ...
BackgroundAlmost 60% ofpatients relapse a              Almost 60% of             patients relapseyear after     a year aft...
BackgroundAlcohol is highly accessible for outpatients
HRV is an index ofinhibitory processesand is also related tocognitive flexibility.                   Thayer & Lane (2000)
We hypothesized Backgroundthat HRV wouldAlmost 60% ofpredict craving             patients relapse               a year aft...
Relationship between HRV and OCDS
We have almostcompleted oxytocintreatment trials onautism, first episodepsychosis, andschizophrenia.
Oxytocin treatment  Backgroundtrial for alcohol                Almost 60% ofdependence.    patients relapse               ...
Discussion•   Oxytocin may ‘break the loop’ of repetitive behaviors    related to drug taking (McGregor & Bowen, 2012)•   ...
Oxytocin showspromise in thetreatment of disorderscharacterized by poorsocial functioning dueto its influence onautonomic ...
Acknowledgements   Dr. Andrew Kemp                 A/Prof. Adam Guastella                  Prof. Iain McGregorSCAN researc...
Questions?For more info on research or any questions:Email - daniel.quintana@sydney.edu.auWeb – http://dsquintana.comTwitt...
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Oxytocin and heart rate variability

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Oxytocin and heart rate variability

  1. 1. Oxytocin andheart ratevariability: A rolein social behaviorand psychiatricillnessDaniel S. Quintana, PhD CandidateSCAN research & teaching unit, School of PsychologyBrain & Mind Research Institute
  2. 2. Oxytocin hastraditionally beenassociated withuterine contractionand the milk let-down reflex. Dale (1906); Ott & Scott (1910)
  3. 3. BackgroundOT studies on social cognition 4x increase 1992-2002 2002-2012
  4. 4. Oxytocinincreasesgaze tothe eyeregion.Guastella et al.,(2008) BiologicalPsychiatry, 63(1).
  5. 5. Oxytocin is acardiovascularhormone.Gutkowska & Janowski (2012) Journalof Neuroendocrinology, 24(4).
  6. 6. BackgroundGutkowska et al., (2007) Am J Physiol,24(4).
  7. 7. The regulation of theautonomic nervoussystem plays a crucialrole in social behavior.Porges (1998)
  8. 8. The autonomic nervous system The vagus nerve is part of a system that communicates between the brain and body
  9. 9. The autonomic nervous system Sinoatrial node
  10. 10. Autonomic nervoussystem activity can beindexed by heart ratevariability (HRV).Berntson et al. (1997)
  11. 11. The autonomic nervous systemHRV is the temporal variation of beats
  12. 12. Why is high variability ‘good’?
  13. 13. The autonomic nervous systemA kr. 2500 NOKPolar heartrate monitor isas good as akr. 90,000 NOKECG system tomeasure HRV. Quintana et al. (2012)
  14. 14. HRV is The autonomic nervous systemreduced indepressionKemp, Quintana et al., (2010) BiologicalPsychiatry, 34 (6); Kemp, Quintana etal., (2012) PLoS One
  15. 15. Is HRV reduced in MDD?*P > 0.01 Kemp, Quintana et al., (2012) PLoS One
  16. 16. Is HRV reduced in MDD with comorbid anxiety? *P > 0.01 Kemp, Quintana et al., (2012) PLoS One
  17. 17. HRV is reduced inalcoholdependence Quintana, Guastella, Kemp et al., (in press) Alcoholism: Experimental & Clinical research
  18. 18. The autonomic nervoussystem regulates theprojection and theperception of emotion.
  19. 19. Polyvagal theory and social behavior Facial muscles Laryngeal &Porges (2007) Biological PharyngealPsychology, 74. muscles
  20. 20. What is this manthinking or feeling?
  21. 21. HRV is related toemotion recognition.
  22. 22. Oxytocin increasesHRV and protectsagainst socialisolation.
  23. 23. Oxytocin and HRV in animals Grippo et al., (2009). Psychoneuroendochronology 34 (10)
  24. 24. Oxytocin nasal sprayincreases HRV in humans. Kemp, Quintana, Guastella et al., (2012) PLoS One
  25. 25. Almost 10% of Backgroundglobal diseaseburden has beenattributed toalcohol.Rehm et al., (2009) Lancet, 373 3
  26. 26. BackgroundAlmost 60% ofpatients relapse a Almost 60% of patients relapseyear after a year aftercommencing commencing treatment fortreatment. alcohol dependenceIlgen et al., (2008) Drug and Alcoholdependence, 92 3
  27. 27. BackgroundAlcohol is highly accessible for outpatients
  28. 28. HRV is an index ofinhibitory processesand is also related tocognitive flexibility. Thayer & Lane (2000)
  29. 29. We hypothesized Backgroundthat HRV wouldAlmost 60% ofpredict craving patients relapse a year afterseverity. commencing treatment for alcohol dependence 3
  30. 30. Relationship between HRV and OCDS
  31. 31. We have almostcompleted oxytocintreatment trials onautism, first episodepsychosis, andschizophrenia.
  32. 32. Oxytocin treatment Backgroundtrial for alcohol Almost 60% ofdependence. patients relapse a year after commencing treatment for alcohol dependence 3
  33. 33. Discussion• Oxytocin may ‘break the loop’ of repetitive behaviors related to drug taking (McGregor & Bowen, 2012)• Placebo controlled, between-subjects design (n = 30).• Participants received oxytocin or placebo for 4 weeks.• Pre and post measures include alcohol intake, social cognition and psychophysiology.• 4 week follow-up after treatment completion.
  34. 34. Oxytocin showspromise in thetreatment of disorderscharacterized by poorsocial functioning dueto its influence onautonomic function.
  35. 35. Acknowledgements Dr. Andrew Kemp A/Prof. Adam Guastella Prof. Iain McGregorSCAN research and teaching unit BMRI School of Psychology School of Psychology University of Sydney University of Sydney University of Sydney Prof. Gin Malhi Prof. Ian Hickie Dr. Maree Abbott Gail Alvares James Heathers Cristina Caccioti-Saija Tim Outhred Ruth Wells John Chalmers CJ Yatawara 17
  36. 36. Questions?For more info on research or any questions:Email - daniel.quintana@sydney.edu.auWeb – http://dsquintana.comTwitter - @dsquintana

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