Regulation of blood glucose (catabolism)

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This is the presentation depicting the major catabolic effects and the various hormones responsible for increasing the concentration of Glucose in blood stream in times of stress and starvation.

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Regulation of blood glucose (catabolism)

  1. 1. Regulationof BloodGlucose (Part-II) Dr. Abhishek Roy JR, Dept. of Biochemistry Grant Govt. Medical College and Sir JJ Group of Hospitals, Mumbai Email: mail@abhishek.ro
  2. 2. Main effects of Growth Hormone
  3. 3. Main effects of Epinephrine
  4. 4. Main effects of Glucocorticoids
  5. 5. Enzyme induction and repression by Glucagon Glu-6-Pase + Fruc-1,6- BPase + PEPCK + Glucokinase - PFK-1 - Pyruvate Kinase -
  6. 6. Variation in glucose phosphorylating activity of hexokinase and glucokinase with increasing blood glucose concentration.The Km for glucose of hexokinase is 0.05 mmol/L and of glucokinase is 10 mmol/L.
  7. 7. Control Of Glycogen Synthase in muscle
  8. 8. Control of Phosphorylase in Muscle
  9. 9. Cori’s Cycle (Lactate Cycle) and Glucose-Alanine Cycle
  10. 10. Triacylglycerol metabolism in adipose tissue. Hormone- sensitive lipase is activated by ACTH,TSH, glucagon, epinephrine, norepinephrine, and vasopressin and inhibited by insulin, prostaglandin E1 , and nicotinic acid. Lipolysis
  11. 11. Lipolysis
  12. 12. Ketogenesis

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