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Xof711	
  
Be#s-­‐LaCroix	
  




11514661	
  
0%	
  
1	
  

        2428036	
  
2	
  
        14159022	
  
Navicore	
     9503344	
  
Beverly	
  &	
  Pack	
  
3?	
  
Is	
  that	
  such	
  good	
  idea?	
  
7	
  years	
  old	
  
Life	
  Expectancy	
  




Year	
  
                                    2217793	
  
2217793	
  




                         No	
  AnLbioLcs	
  
Life	
  Expectancy	
  




                                  Year	
  
Life	
  Expectancy	
  




                         No	
  AnLbioLcs	
  




                                               Year	
  
200	
  




Life	
  Expectancy	
  




                         No	
  AnLbioLcs	
  




                                               Year	
  
200	
  




                         No	
  AnL-­‐Aging	
  
Life	
  Expectancy	
  
                          Therapies	
  



                           No	
  AnLbioLcs	
  




                                                 Year	
  
OverpopulaLon?	
  
Niger	
  
Niger	
  




    World	
  
Niger	
  




    World	
  




                Switzerland	
  
Life	
  

                          Extension	
  



Joep	
  de	
  Graaff	
  
Health	
  
Extension	
  
Aging	
  Theories	
  
•    Wear	
  and	
  Tear	
  
•    DNA	
  Damage/Errors	
  
•    Programmed	
  Limits	
  
•    Senescent	
  Cells	
  
•    Mitochondria/Free	
  Radicals	
  
•    Telomere	
  Shortening	
  
•    Garbage	
  AccumulaLon	
  
•    Etc.	
  
DR.	
  AUBREY	
  DE	
  GREY	
  
 SENS	
  FoundaLon	
  	
  




Metabolism                         Damage   Pathology
Geriatric$



Metabolism   Damage       Pathology
Gerontology



Metabolism      Damage   Pathology
Metabolism   Damage   Pathology


             Repair
+	
  


                        +	
  
Tianhe-­‐1A	
  	
  
                      Watson	
  Jeopardy	
  
37,500-­‐probe	
  spobed	
  oligo	
  microarray	
  
Nissim	
  Benvenisty	
  


RegeneraLve	
  Medicine	
  /	
  Stem	
  Cells	
  
Roman	
  Klementschitz	
  
9503344	
  
marcusjroberts	
  
1	
        Usual	
  




            50	
  Years	
  




2	
     Slow	
  Aging	
  
1	
        Usual	
  




            50	
  Years	
  




2	
     Slow	
  Aging	
  
                              New	
  
                              Stuff	
  
1	
        Usual	
  




            50	
  Years	
  




2	
     Slow	
  Aging	
  
                              New	
  
                              Stuff	
  
1	
        Usual	
  




            50	
  Years	
  




2	
     Slow	
  Aging	
  
                              New	
  
                              Stuff	
  
                                         More	
  
                                         Stuff	
  
possible	
  
possible	
  
possible	
  
possible	
  
possible	
  
join	
  us!	
  
A	
  community	
  
extending	
  healthy	
  life	
  
beyond	
  current	
  limits	
  
Thank	
  you!	
  
Healthy	
  
   Happy	
  
123-­‐Year-­‐Old	
  
122	
  
123	
  
          1915	
  
Aging	
  is	
  separate	
  from	
  disease	
  
Most	
  fatal	
  diseases	
  result	
  from	
  aging	
  
We	
  are	
  treaLng	
  symptoms,	
  	
  
              not	
  causes	
  	
  
Cancer	
  




            Age	
  
hbp://www.mabstrust.co.uk/incidence/	
  
Cancer	
  




  Age	
  
Cancer	
  




Aging	
  


       Age	
  
Alzheimer’s	
  


                             Aging	
  

                                               age	
  


hbp://chronopause.com/index.php/2012/04/02/much-­‐less-­‐than-­‐half-­‐a-­‐chance-­‐part-­‐1/	
  
Cardiovascular	
  disease	
  
                        Stroke	
  

           Aging	
  

              age	
  


              Heart	
  Aback	
  

           Aging	
  

              age	
  
 hbp://ajcn.nutriLon.org/content/76/1/93.full.pdf+html	
  
Funding	
  
	
  
Healthcare:	
   	
   	
   	
   	
   	
  $2,500	
  Billion	
  
Funding	
  
	
  
Healthcare:	
   	
   	
   	
   	
   	
  $2,500	
  Billion	
  
Biological	
  Research:	
   	
  	
  	
  	
  	
  	
  	
  $60	
  Billion	
  
Funding	
  
	
  
Healthcare:	
   	
   	
   	
   	
   	
  $2,500	
  Billion	
  
Biological	
  Research:	
   	
  	
  	
  	
  	
  	
  	
  $60	
  Billion	
  
Biology	
  of	
  Aging:	
   	
   	
   	
  	
  	
  	
  	
  	
  	
  	
  	
  $0.25	
  Bn	
  
Funding	
  
	
  
Healthcare:	
   	
   	
   	
   	
   	
  $2,500	
  Billion	
  
Biological	
  Research:	
   	
  	
  	
  	
  	
  	
  	
  $60	
  Billion	
  
Biology	
  of	
  Aging:	
   	
   	
   	
  	
  	
  	
  	
  	
  	
  	
  	
  $0.25	
  Bn	
  
Applied	
  Biology	
  of	
  Aging:	
  	
  	
  $0.025	
  Bn	
  
	
  
Funding	
  
	
  
Healthcare:	
   	
   	
   	
   	
   	
  $2,500	
  Billion	
  
Biological	
  Research:	
   	
  	
  	
  	
  	
  	
  	
  $60	
  Billion	
  
Biology	
  of	
  Aging:	
   	
   	
   	
  	
  	
  	
  	
  	
  	
  	
  	
  $0.25	
  Bn	
  
Applied	
  Biology	
  of	
  Aging:	
  	
  	
  $0.025	
  Bn	
  
	
  
                  0.001%	
  à	
  1%	
  
Funding	
  
	
  
Healthcare:	
   	
   	
   	
   	
   	
  $2,500	
  Billion	
  
Biological	
  Research:	
   	
  	
  	
  	
  	
  	
  	
  $60	
  Billion	
  
Biology	
  of	
  Aging:	
   	
   	
   	
  	
  	
  	
  	
  	
  	
  	
  	
  $0.25	
  Bn	
  
Applied	
  Biology	
  of	
  Aging:	
  	
  	
  $0.025	
  Bn	
  
	
  
                  0.001%	
  à	
  1%	
  
Prof.	
  Stuart	
  Kim,	
  Stanford	
  
Dr.	
  Judith	
  Campisi,	
  Buck	
  InsLtute	
  
Dr.	
  Oki	
  O’Connor,	
  SENS	
  FoundaLon	
  
Dr.	
  Saul	
  Villeda,	
  UCSF	
  
“Young	
  blood	
  enhances	
  
synapLc	
  plasLcity	
  and	
  
cogniLve	
  funcLon	
  in	
  the	
  old	
  
brain.”	
  
Next	
  Thursday,	
  27-­‐Feb	
  
	
  
6PM	
  
	
  
Y	
  Combinator,	
  Mt.	
  View	
  
	
  
HealthExtension.co	
  
	
  
Science	
  Pitches	
  
Health	
  Extension	
  Retreat	
  
                             Santa	
  Cruz	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  Jan	
  2-­‐9	
  
Dinelle	
  Lucchesi	
  
Helen	
  Huang	
  
Jason	
  Xu	
  
Minda	
  Myers	
  
Brian	
  Null	
  
Ryan	
  Gibson	
  
Tanya	
  Jones	
  
Alex	
  Carmichael	
  
Adam	
  Sheppard	
  
Lisa	
  Bebs-­‐LaCroix	
  
Joe	
  Bebs-­‐LaCroix	
  
Barrie	
  Robinson	
  
John	
  Schloendorn	
  
Aging	
  Variants	
  Database	
  Project	
  
ScienLfic	
  Ideas	
  




      (cc:	
  AT-­‐SA)	
  Sarah	
  Katzenell	
  
Money	
  
join	
  us!	
  
Ways	
  to	
  get	
  involved	
  
•    Abend	
  a	
  dinner	
  Salon	
  
•    Pitch	
  your	
  project	
  
•    Do	
  research	
  as	
  an	
  intern	
  
•    Pursue	
  a	
  project	
  in	
  our	
  incubator	
  
•    Abend	
  a	
  brainstorming	
  retreat	
  
•    Help	
  at	
  a	
  workshop	
  
        HealthExtension.co	
  
Thank	
  you!	
  
            	
  




joe@HealthExtension.co	
  
Backup	
  
Laura	
  Deming	
  

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