Definiens Tissue Studio™<br />The Most Advanced Digital Pathology Image Analysis Solution <br />
Definiens Tissue Studio™ overview<br />Enables simple, fast, and accurate ROI detection via the new Definiens Composer Tec...
Definiens Composer Technology™<br />What is it?<br />Definiens Composer Technology™ was developed to enable the user to ea...
ROI Detection and Cell by Cell Analysis across and within selected ROIs<br />Definiens Tissue Studio™ Workflow<br />
Load training images<br />
Define image analysis solution<br />
Load up to four different images:Detect tissue / Background / Segment images<br />
Definiens Composer Technology™:“Paint” on a few representative ROIs<br />
Definiens Composer Technology™:After painting a few ROIs, click the “Learn” button<br />
Definiens Composer Technology™:Computer has now been “trained”<br />
Definiens Composer Technology™:Merge “Object Primitives”<br />
Second Definiens Composer step:Re-classify Islets into “tumor” and “normal”<br />
Select ROIs in tumor islets<br />
ROIs at 20xParameters can be adjusted and previewed here<br />
Detect nuclei<br />
Batch Process:Analyze selected images<br />
Export multi-parametric quantitative features<br />
List of supported instruments<br />Hamamatsu: Nanozoomer<br />Zeiss: Mirax<br />Aperio: Scanscope<br />Applied Imaging: Ar...
Summary<br />Deeper insights <br />Quantifies nuclear, membrane and cytoplasmic biomarkers on a cell-by-cell basis <br />S...
Questions Contact:<br />Daniel R. Nicolson<br />Director, Global Accounts<br />484-678-9090<br />dnicolson@definiens.com <...
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Definiens Tissue Studio Advanced Digital Pathology Image Analysis Solution

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The Most Advanced Digital Pathology Image Analysis Solution

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Definiens Tissue Studio Advanced Digital Pathology Image Analysis Solution

  1. 1. Definiens Tissue Studio™<br />The Most Advanced Digital Pathology Image Analysis Solution <br />
  2. 2. Definiens Tissue Studio™ overview<br />Enables simple, fast, and accurate ROI detection via the new Definiens Composer Technology™<br />Provides multi-parametric quantitationon a cell-by-cell basis<br />Handles heterogeneous tissue samples<br />Works with whole slides and TMAs<br />Handles images acquired from any source<br />Operates as a dedicated workstation or as a client server application<br />
  3. 3. Definiens Composer Technology™<br />What is it?<br />Definiens Composer Technology™ was developed to enable the user to easily teach the system how to identify regions of interest (ROIs). <br />How does it work?<br />Simply load up to 4 representative images, and use the “paintbrush tool” on a few representative ROIs in your images. Then click the “Learn” button.<br />How does this differ from other approaches? <br />Training the system with 4 representative images ensures a robust image analysis solution without over fitting.<br />Combines machine learning, pattern recognition and auto adaptive analysis algorithms based on Definiens eCognitionNetwork Language ™.<br />Definiens Tissue Studio™ is faster and more flexible.<br />
  4. 4. ROI Detection and Cell by Cell Analysis across and within selected ROIs<br />Definiens Tissue Studio™ Workflow<br />
  5. 5. Load training images<br />
  6. 6. Define image analysis solution<br />
  7. 7. Load up to four different images:Detect tissue / Background / Segment images<br />
  8. 8. Definiens Composer Technology™:“Paint” on a few representative ROIs<br />
  9. 9. Definiens Composer Technology™:After painting a few ROIs, click the “Learn” button<br />
  10. 10. Definiens Composer Technology™:Computer has now been “trained”<br />
  11. 11. Definiens Composer Technology™:Merge “Object Primitives”<br />
  12. 12. Second Definiens Composer step:Re-classify Islets into “tumor” and “normal”<br />
  13. 13. Select ROIs in tumor islets<br />
  14. 14. ROIs at 20xParameters can be adjusted and previewed here<br />
  15. 15. Detect nuclei<br />
  16. 16. Batch Process:Analyze selected images<br />
  17. 17. Export multi-parametric quantitative features<br />
  18. 18. List of supported instruments<br />Hamamatsu: Nanozoomer<br />Zeiss: Mirax<br />Aperio: Scanscope<br />Applied Imaging: Ariol<br />TissueGnostics<br />Bacus WebSlide<br />DMetrix<br />Generic (tif, jpg, etc.)<br />
  19. 19. Summary<br />Deeper insights <br />Quantifies nuclear, membrane and cytoplasmic biomarkers on a cell-by-cell basis <br />Supports all standard IHC tissue stains (blue, brown and red), H&E and IF <br />Analyzes all slides and TMA images from all major image acquisition devices  <br />Faster results <br />Identifies regions of interest automatically<br />Operates through a simple, intuitive user interface <br />Offers unlimited throughput with parallel batch processing <br />Better decisions <br />Delivers accurate and reproducible results <br />Enables multiparametric investigations to identify underlying correlations <br />Supports translational research through rapid iterative investigation of biomarkers <br />
  20. 20. Questions Contact:<br />Daniel R. Nicolson<br />Director, Global Accounts<br />484-678-9090<br />dnicolson@definiens.com <br />

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