Amebiasis(Amebic Dysentery)Causal agent: Entamoeba histolytica is well recognizedas a pathogenic amoeba.Geographic Distribution: Worldwide, with higherincidence of amebiasis in developing countries.In industrialized countries, risk groups include malehomosexuals, travelers and recent immigrants, andinstitutionalized populations.History: Loosh was first described in 1875
Epidemiology• Prevalence of amebic infection varies with level of sanitationand generally higher in tropics and subtropics than intempearate climates.• *Worldwide prevalence is about 10% to 50%• *Cyst passers are important source of infection• The true estimated prevalence of E. histolytica is close to 1%worldwide.• Entamoeba histolytica is the second leading cause ofmortality due to parasitic disease in humans. (The first beingmalaria). Amebiasis is the cause of an estimated 50,000-100,000 deaths each year.
Transmission• 1-driect contact of person to person( fecal-oral)• 2- Veneral transmission among homosexualmales( oral-anal• 3- Food or drink contaminated with feces containingthe E.his. cyst• 4- Use of human feces (night soil) for soil fertilizer• 5- contamination of foodstuffs by flies, and possiblycockroaches
Pathogenesis• Effective factores:• 1- strain virulence:• 2- susceptibility of the host; nutrition status, immune-sys.• 3- breakdown of immunologic barrier (tissue invasion)
This is an amebic abscess of liver. Abscesses may arise in liver when there is seeding ofinfection from the bowel, because the infectious agents are carried to the liver from theportal venous circulation.
• The abscesses persist after the acuteintestinal illness has passed and may, rarely,reach the lung and the heart by directextension from the liver.
AMEBIC COLITIS• Simulate ulcerative colitis or Crohn’s disease• Gross: ulceration covered by exudate, with normalintervening mucosa• Site: cecum and ascending colon• L/M: nonspecific• Flask shaped ulcer,• Trophozoites of E. histolytica• Erythrocytosis by trophozoites usually present• Can be detected by Heidenhain’s iron hematoxylinstain and PAS
• Amebae may also spread via thebloodstream into the kidneys and brain.
Clinical features• Abdominal pain, bloody diarrhea, or weightloss. Occasionally, acute necrotizing colitisand megacolon occur, and both areassociated with significant mortality.
Treatment• The parasites lack mitochondria or Krebscycle enzymes and are thus obligatefermenters of glucose. Therefore,metronidazole, which inhibits the enzymepyruvate oxidoreductase that is required forfermentation, is the most effectivetreatment.
Morphology• Ingested Mycobacterium tuberculosis inciteschronic inflammation and granulomaformation in mucosal lymphoid tissue--particularly Peyer’s patches in the terminalileum– and regional lymph nodes
TUBERCULOSIS• Site: ileocecal area• Gross: ulceration with diffuse fibrosisextending through wall→ stenosis andobstruction• Tuberculous peritonitis• L/M: ulceration, granuloma and desmoplasia• Vasculitis, non-specific, diffuse, chronicinflammation with fibrosis• AFB for definite diagnosis
TYPHOID FEVER• Typhoid fever, also referred to as entericfever, is caused by Salmonella typhi andSalmonella paratyphi.