A CASE OF MESENCHYMAL CHONDROSARCOMA Department of Anatomical Pathology, University of Limpopo-MEDUNSA  CAMPUS References ...
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Extra-mesenchymal Chondrosarcoma

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A case report of extra-mesenchymal chondrosarcoma

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Extra-mesenchymal Chondrosarcoma

  1. 1. A CASE OF MESENCHYMAL CHONDROSARCOMA Department of Anatomical Pathology, University of Limpopo-MEDUNSA CAMPUS References Discussion Background Objective Materials & Methods Conclusion <ul><ul><ul><li>Arch Pathol Lab Med—Vol 131, February 2007 </li></ul></ul></ul><ul><ul><ul><li>Weis S, Goldblum J.  Cartilaginous Soft Tissue Tumors. In: Weis S, Goldblum J, editors.  Enzinger and Weis’s Soft Tissue Tumors, 4 th Edition. 2001. p 1361-1388. </li></ul></ul></ul><ul><li>A 41 year female with a large left thigh mass. </li></ul><ul><li>She also has a small mass on the back of the right shoulder which has a remarkable increase in contrast uptake on nuclear scan. </li></ul><ul><li>She has a previous history of an excision of a thyroid mass done at a private institution and the biopsy result was that of a Chondrosarcoma . </li></ul><ul><li>. </li></ul>. . <ul><li>The gross, histological features and immunohistochemical profile of this tumour are those of a extraskeletal mesenchymal chondrosarcoma. </li></ul><ul><li>An incisional biopsy of the left thigh mass was performed and the result was a mesenchymal chondrosarcoma. </li></ul><ul><li>Then an excisional biopsy was done. </li></ul>  Immunohistochemistry – S100 - Positive Vimentin - Positive; Cytokeratin AE/13 - Negative. . <ul><li>Microscopic findings – </li></ul><ul><li>The sections show a diffuse proliferation of pleomorphic small, round to oval cells. </li></ul><ul><li>In some areas, a haemangiopericytoma-like growth pattern is present. </li></ul><ul><li>Cartilagenious areas with mild pleomorphism of chondrocytes in the lacunae and calcifications are present. </li></ul>H & E SKOSANA KC, BIDA MN Vimentin S100 AE1/AE3 Results Introduction <ul><li>Mesenchymal chondrosarcomas constitute less than 2 % of all chondrosarcomas. </li></ul><ul><li>Approximately two thirds of cases of mesenchymal chondrosarcoma occur in bone while the rest occur in places outside of the bone—i.e.in extraskeletal locations. </li></ul><ul><li>They are aggressive lesions with a high propensity for metastases. </li></ul><ul><li>Mesenchymal chondrosarcoma is a fast growing tumor that spreads more often.  </li></ul><ul><li>They can remain dormant for long periods of time. </li></ul><ul><li>This case illustrates multi-focality, recurrence and metachronous nature of a extraskeletal mesenchymal chondrosarcoma. </li></ul>

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