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Ivms bms general principles usmle web maps


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Ivms bms general principles usmle web maps

  1. 1. USMLE WEB MAPS-BMS GENERAL PRINCIPLES IVMS is the ultimate medical student Web 2.0 companion. This SDL-Face to Face hybrid courseware is a digitally tagged and content enhanced replication of the United States Medical Licensing Examinations Cognitive Learning Objectives (Steps 1, 2 or 3). Including authoritative reusable learning object (RLO) integration and scholarly Web Interactive PowerPoint-driven multimedia shows/PDFs. Comprehensive hypermedia BMS learning outcomes and detailed, General Principles and Organ System USMLE Web Maps content enriched learning objectives. COMPONENT I: BIOCHEMISTRY AND MOLECULAR BIOLOGY delves into gene expression, protein synthesis, energy metabolism and the metabolic pathways associated with diseases. GENE EXPRESSION: DNA STRUCTURE, REPLICATION AND EXCHANGE1.1.1 DNA structure: single- and double-stranded DNA, stabilizing forces, supercoiling HGP.pdf DNA and Molecular Genetics DNA Structure and Analysis Gene expression: DNA structure, replication, and exchange1.1.2 Analysis of DNA: sequencing, restriction analysis, PCR amplification, hybridization DNA Sequence Analysis: Introduction 1.1.3 DNA replication, mutation, repair, degradation, and inactivation DNA Synthesis.ppt DNA Synthesis. notes IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  2. 2. 1.1.4 Gene Structure and Organization; chromosomes, centromere and telomere Genes and Gene Organization Gene Structure and Genomic Sequence 1.1.5 Recombination, insertion sequences, transposons DNA Recombination Insertion Sequences. Notes Transposons: Mobile DNA .notes1.1.6 Mechanisms of genetic exchange: transformation, transduction, conjugation, cross-over, recombination, linkage Genetic Exchange Mechanisms Slides 4-13 Microbial Genetic Exchange 1.1.7 Plasmids and bacteriophages Cells Alive and T4 Bacteriophages Introduction to the Bacteriophages T4 Virus Inserting a DNA Sample into a Plasmid GENE EXPRESSION: TRANSCRIPTION (INCLUDING DEFECTS)1.2.1 Transcription of DNA into RNA, enzymatic reactions, RNA, RNA degradation Dr Chromos School: transcription of DNA into RNA Transcription-Synthesis of Messenger RNA (mRNA)1.2.2 Regulation: cis-regulatory elements, transcription factors, enhancers, promoters, silencers,repressants, splicing Transcription Regulation Gene Regulation: Summary Principles and Overview .PDF GENE EXPRESSION: TRANSLATION INCLUDING DEFECT 1.3.1 The genetic code Introduction to Bioinformatics The Genetic Code The Human Genome Project Genetic Code Table and the 20 Amino Acids DNA-Basics of Structure and Analysis IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  3. 3. 1.3.2 Structure and function of tRNA Structure and function of transfer RNA Transfer RNA 1.3.3 Structure and function of ribosomes Ribosome Structure and Function Ribosome Structure and Assembly 1.3.4 Protein synthesis Protein Synthesis Comprehensive Protein Synthesis (Animation) Protein Synthesis Summary.ppt 1.3.5 Regulation of translation Regulation of Translation. Illus. notes Translation.ppt 1.3.6 Post-translational modifications (phosphorylation, addition of CHO units) Post-Translational Modifications 1.3.7 Protein degradation Protein Degradation Resource. notes STRUCTURE & FUNCTION OF PROTEINS 1.4.1 Principles of protein structure and folding Protein Structure: The Very Basics .pps 1.4.2 Enzymes: kinetics, reaction mechanisms Symbolism and Terminology in Enzyme Kinetics Enzymes and Enzyme Complexes 1.4.3 Structural and regulatory proteins: ligand binding, self-assembly Regulatory Protein Coordinating Gene Expression 1.4.4 Regulatory propertiesRegulation of Enzyme Activity.pptEnzyme Regulatory Mechanisms ENERGY METABOLISM (METABOLIC SEQUENCES & REGULATION) & DISORDERS IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  4. 4. 1.5.1 Generation of energy from carbohydrates, fatty acids, and essential amino acids; glycolysis, pentose phosphate pathway, tricarboxylic acid cycle, ketogenesis, electron transport and oxidative phosphorylation, glycogenolysis Step by Step Krebs cycle Metabolic Pathways and Energy Production.ppt Krebs citric acid cycle Energy Production.ppt Summary Diagram of the Krebs cycle Electron Transport and Oxidative Phosphorylation .pps 1.5.2 Storage of energy: gluconeogenesis, glycogenesis, fatty acid and triglyceride synthesis How Cells Store Energy: ATP. Notes (with Quiz) Metabolism and Energy Balance.ppt1.5.3 Thermodynamics: free energy, chemical equilibria and group transfer potential,energetics of ATP and other high-energy compounds Energy is conserved: The First Law of Thermodynamics. Notes Laws of Thermodynamics METABOLIC PATHWAY OF SMALL MOLECULES AND ASSOCIATED DISEASES Medical Biochemistry Page IndState-Dr King Inborn Errors of Amino Acid Metabolism.html notes Biochemical Pathways-Metabolic Pathways-Comprehensive Map1.6.1 Biosynthesis and degradation of amino acids (eg, homocystinuria)1.6.2 Biosynthesis and degradation of purine and pyrimidine nucleotides (eg, gout, Lesch-Nyhan syndrome)1.6.3 Biosynthesis and degradation of lipids (eg, dyslipidemias, carnitine deficiency,adrenogenital syndromes)1.6.4 Biosynthesis and degradation of porphyrins1.6.5 Biosynthesis and degradation of other macromolecules and associated abnormalities,complex carbohydrates (eg, lysosomal storage disease), glycoproteins, and proteoglycans NetBiochem: Topics, Tables and Still and Animated Graphics Biochemistry Pathways Illustrated Interactive Concepts in Biochemistry - Interactive Animations IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  5. 5. COMPONENT II: CELLULAR BIOLOGY with emphasis on structure and function of organelles, adaptive mechanisms and apoptosis.2.1 Signal transduction: second messenger systems - voltage- and ligand-gated channels andreceptors Mechanisms of Single Transduction Single Transduction with Link to Vitamin & Coenzymes Notes2.2 Cell components (eg, endoplasmic reticulum, plasma membrane, nucleus, ribosomes) UTMB- Illustrated Cell Biology Topics Cellular and Molecular Processes-Comprehensive Map Tutorial on Biological Membranes 2.3 Cytoskeleton (including cell movement and intracellular transport) Cytoskeleton Tutorial 2.4 Secretion and exocytosis, endocytosis, transcytosis Eukaryote vs Prokaryote Secretion, Endocytosis and Exocytosis.ppt2.5 Cell cycle: mitosis, meiosis, structure and regulation of spindle apparatus, control points Mitosis: Labeled Diagram Cell Cycle and Mitosis Tutorial Cell Division and Genetic Consequences Meiosis Tutorial Cell Cycle, Mitosis and Cell Differientation.ppt2.6 Epithelial cells (including surface specialization, intercellular junctions, gap junctions, anddesmosomes) Tissues /e-Histology. Net Membrane Structure and Function: Cell Junction Proteins IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  6. 6. Cells gap junctions, tight junctions and desmosomes (Slides 37-48) Junctions Between Cells2.7 Fibroblasts, endothelial cells, and mesenchymal cells: basement membrane, extracellularmatrix, proteoglycans, fibronectins, adhesion molecules, annexins Connective Tissues .ppt Cytology and Histology of Connective Tissue2.8 Muscle cells (cardiac, smooth, skeletal): structure and regulation of contractile elements,excitation-contraction coupling Cardiac and Smooth Muscle Muscle Mechanism of Contraction and Neural Control.ppt Muscle Physiology and Design. Illus. notes2.9 Adaptive mechanism: cell response to injury (eg, hypertrophy, metaplasia) The Immune Response to Burn Injury Hypertrophy, heart, gross Cell Injury Illustrated Lecture Notes2.10 Mechanisms of cell injury and necrosis (including free radical mediated cell injury) Cell Injury and Adaptation Mechanisms Inflammation 2.11 Apoptosis (programmed cell death) Apoptosis.html notes Apoptosis.html-Another Look IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  7. 7. COMPONENT III: GENETICS & HUMAN DEVELOPMENT with stress on embryogenesis, Mendelian genetics, population genetics, pedigree analysis, genetic abnormalities and counseling.3.0. Embryology: fertilization, cleavage, blastulation, gastrulation, neurulation, and structuresarising out of primary germ cell. Early Development Human Growth and Development The Visible Embryo ProjectEmbryogenesis: programmed gene expression, tissue differentiation and morphogenesis,homeotic genesEmbryology-In the Womb Human Embryogenesis 3.1. Congenital abnormalities: principles, patterns of anomalies, dysmorphogenesis Congenital Anomalies 3.2. Principles of pedigree analysis: inheritance patterns, occurrence and recurrence risk General Principles of Medical Genetics 3.3. Population genetics: Hardy-Weinberg law, founder effects, mutation-selection equilibrium Population Genetics Population Genetics for 1st Year Medical Students 3.4. Genetic mechanisms: chromosomal abnormalities, mendelian inheritance, multifactorial diseases Terms to Know in Mendelian Genetics Genetic Linkage and Mapping Mendelian genetics Problem Sets and Tutorials Chromosomal Aberrations (simplified lecture notes) General Principles of Medical Genetics (Comprehensive lecture notes) Medical Genetics Comprehensive PDF Notes IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  8. 8. 3.5. Clinical correlates of genetics: genetic testing, prediagnosis, newborn General Principles of Medical Genetics-Clinical Correlates COMPONENT IV: IMMUNOLOGY: BASIC & APPLIED It explains the functions of the cells involved in immune response, classification of response, genetic regulation of immunogenicity (MHC class molecules), immune impairment and the laboratory techniques in immunologic investigations.Immune system: goal, division & general function Immune System.html notes Adaptive -Innate Immunity Interplay Animation: Neutralization I Opsonization I Classical complement pathway I Alternatecomplement pathway 4.1. Histoimmunology: production and function of granulocytes, natural killer cells, macrophages An Immune System Glossary Granulocytes, Macrophages and Natural Killer Cells.htm notes 4.2. Production and function of T lymphocytes, T lymphocyte receptors The Immune Response System The Adaptive Immune Response -T4 Lymphocytes B lymphocytes- T lymphocyte interactions.ppt 4.3. Production and function of B lymphocytes and plasma cells; immunoglobulin and antibodies: structure and biologic properties The Immune System-Humoral Development of B-Cells.ppt Immunoglobulin Structure 4.4. Antigenicity and immunogenicity; antigen presentation; cell activation and regulation; tolerance and clonal deletion IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  9. 9. Hematopoiesis.htm notes 4.5. Immunologic mediators: chemistry, function, molecular biology, classic and alternative complement pathways, cytokines, chemokines The Complement System.html Lect Notes The Role of Complement in Elimination of Microorganisms Complement System -Lectin Pathway 4.6. Immunogenetics; MHC structure and function, class I, II molecules; erythrocyte antigens; transplantation Histocompatability Molecules (Excellent illustration of MHC I & II Molecules) Class I and II MHC 4.7. Immunizations: vaccines, protective immunity Epidemiology and Prevention of Vaccine Preventable Diseases 4.8. Immunopathology: Alterations in immunologic response & function Immunological Defects 4.8.1 T or B lymphocyte deficiencies B-Cell and T-Cell Screening Test.htm Primary Immune Deficency.htm 4.8.2 Deficiencies of phagocytic cells Phagocytic Cell Defects 4.8.3 Combined immunodeficiency disease Severe Combined Immunodeficency.htm notes Primary Immune Deficiency Disease.html notes 4.8.4 HIV infection/AIDS and other acquired disorders of immune responsiveness HIV/AIDS-What it is -a consumer level overview.html4.9. Immunopharmacology: drug-induced alterations in immune responses Immunopathology: immunologically mediated disorders- hypersensitivity (types I-IV) Immunopathology.html IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  10. 10. Hypersensitivity .htm 4.11.1 Transplant rejection Hypersensitivity Reactions and Tissue Injury4.11.2 Risks of transplantation, transfusion (eg, graft-versus-host disease), hemolytic disease of the newborn IMMUNOLABORATORY: immunologic principles underlying diagnostic laboratory tests(eg, ELISA, complement fixation, RIA, agglutination) link to commonly utilized immunologic tests) COMPONENT V: MICROBIOLOGY & INFECTIOUS DISEASES this component commences with taxonomy, and delves into bacteriology, virology, mycology and parasitology. Throughout the presentation, reference is made to the laboratory diagnosis and the mechanisms of infectivity. 4.0. TAXONOMY: microbial classification and its basis Classification of Microorganisms. PDF Classification of Microorganisms.ppt Prokaryotes.ppt Classification of Microorganisms.html illustrated notes5.1. BACTERIOLOGY: Bacteria and bacterial diseases IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  11. 11. Bacterial Structure in Relation to Pathogenicity Microbiology Laboratory Techniques.ppt Bacteriology Tutorials.htmStructure and composition Gram Negative Bacteria.html notes Bacteria Structure and Growth.ppt Structure -Function Pathogenicity RelationshipMetabolism, physiology, genetics and regulationNature and mechanisms of action of virulence factors Bacterial MetabolismPathophysiology of infection Principles of Pathogenesis Bacterial Infection.pptBacterial PathogenesisEpidemiology and ecology Infectious Disease EpidemololgyRoute of infection 4.17 Principles of cultivation, assay, and laboratory diagnosis 5.2. VIROLOGY: Viruses and viral diseases- physical and chemical properties - replication (viral genetics) Principles of cultivation, assay, and laboratory diagnosis - molecular basis of pathogenesis of infection latent and persistent infections –epidemiology- oncogenic viruses IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  12. 12. 5.3. MYCOLOGY: Fungi and fungal infections - structure, physiology, cultivation, and laboratory diagnosis - pathogenesis and epidemiology 5.4. PARASITOLOGY: parasites and parasitic diseases, physiology, and laboratory diagnosis- pathogenesis and epidemiology LABORATORY TECNIQUES: principles of sterilization and pure culture technique COMPONENT VI: GENERAL PATHOLOGY: PATHOGENESIS AND BIOLOGY OF TISSUE RESPONSE TO DISEASE deals with inflammation (cells & mediators), reparative process and the basic concepts in neoplasia including carcinogenesis, tumor immunology and cancer epidemiology, prevention and control. 6.1. INFLAMMATION (CELLS AND MEDIATORS)IVMS-General Pathology- Inflammation PPt. Index HTML. Page(excellent, most comprehensive pathologic basis of inflammation – highly recommended) inflammation and mediator systems (pharmacologic mediators)IVMS-Anti-Inflammatory and Autacoid Pharmacology- NSAIDsVascular response to injury (including mediators) Inflammatory cell recruitment (adherence andcell migration) and phagocytosis IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  13. 13. Bactericidal mechanisms and tissue injuryClinical manifestations (including pain, fever, leukocytosis, leukemoid reaction, and chills) inflammationCHRONIC INFLAMMATION AND WOUND HEALINGIVMS Inflammation Notes 6.2. REPARATIVE PROCESSES Inflammation and Repair Illustrated LecturesWound healing, hemostasis, and repair: thrombosis, granulation tissue, angiogenesis, fibrosis,and scar/keloid formation wounds heal and tumors form Regenerative processes 6.3. NEOPLASIA (excellentclassification of neoplasm) Classification, histologic diagnosis Grading, and staging of neoplasms (Biology & epidemiology ofcancer)Cell biology, biochemistry, and molecular biology of neoplastic cells: transformation, oncogenes,altered cell differentiation, and proliferation neoplastic disordersInvasion and metastasis (mechanism & subtypes) biologic mechanism ofmetastasis IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  14. 14. immunology manifestations of cancerIVMS-Gen Tumors, Host and Paraneoplastic Syndromes epidemiology, control and prevention COMPONENT VII: BEHAVIORAL SCIENCES with materials covering organic correlates of behavior, life cycle, human behavior in illness, patients’ interview and medical law and ethics. Medical law & ethics is treated with emphasis on patients’ rights, physician-patient relationship, beginning & end of life issues, clinical research & human experimentation and the ethics of managed care.Gender, ethnic, and behavioral considerations affecting disease treatment and prevention(including psychosocial, cultural, occupational, and environmental)7.0 BEHAVIORAL CORRELATES: neuroanatomical, neurochemistry, neuropharmacologic,genetic & Psychologic; DSM IV classification of mental illness; Common psychotropic agentsAmerican Psychiatric Association - DSM-IV-TReMedicine - PsychiatryLong - Internet Mental Health brain.htmNeurotramsnitters IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  15. 15. Neurotransmitters7.1 LIFE CYCLE: progression through the life cycle (birth through senescence)7.1.1. Cognitive, language, motor skills, and social and interpersonal development Child and Adolescent Development 7.1.2. HUMAN SEXUALITY: sexual development (eg, puberty, menopause) 7.1.3. Influence of developmental stage on physician/patient interview HUMAN BEHAVIOR IN ILLNESS (psychologic and social factors influencing patientbehavior) 7.2.1. Personality traits or coping style (coping mechanisms) International Encyclopedia of Social and Behavioral Science (excellent on personality theory) on defense mechanism) 7.2.2. Psychodynamic and behavioral factors, related past experience 7.2.3. Family and cultural factors, including socioeconomic status, ethnicity, and gender Adaptive and maladaptive behavioral responses to stress and illness (eg,drug-seeking behavior, sleep deprivation) 7.2.4. Interactions between the patient and the physician or the health care system (eg, transference) IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  16. 16. 7.2.5. Patient adherence (general and adolescent) Patient Adherence /Compliance Assessment Instrument.htm Self-assessment of Personality Theory Guide to Personality Theory with quiz.htm7.3. PATIENT INTERVIEWING, CONSULTATION & INTERACTIONS WITH FAMILY Establishing and maintaining rapport Data gathering 7.3.3. Approaches to patient education relationship 7.3.4. Enticing patients to make life-style changes 7.3.5. Communicating bad news 7.3.6. “Difficult” interviews (eg, anxious or angry patients) 7.3.7. Multicultural ethnic characteristics Clues. NotesCultural Competency Resources Guidelines/. Html 7.4. MEDICAL LAW & ETHICS 7.4.1. PATIENTS’ RIGHTS: consent and informed consent to treatment 7.4.2. Physician-patient relationships (eg, ethical conduct, confidentiality) 7.4.3. END OF LIFE - death and dying, right to die? IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  17. 17. 7.4.4. BEGINNING OF LIFE – Legal & Ethical Birth-related issues 7.4.5. HUMAN EXPERIMENTATION (issues related to patient participation in research – clinical trials & informed consent) - research 7.4.6. Interactions with other health professionals (eg, referral) 7.4.7. HUMAN SEXUALITY and the profession, other “boundary” issues 7.4.8. Ethics of managed care 7.4.9. Organization and cost of health-care delivery IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  18. 18. COMPONENT VIII: EXTERNAL (EXTRINSIC) FACTORS IN DISEASE This component treats of nutritional issues (nutrients classification, functions of nutrients & nutritional deficiencies), thermoregulation, and adaptation to environment and homeostasis.MULTI-SYSTEM PROCESSESEnvironmental Pathology Overview 1. NUTRITIONGeneration, expenditure, and storage of energy at the whole-body levelGlycolysis.html notesGluconeogenesis.html notesAssessment of nutritional status across the life span (eg, calories, protein, essential nutrients,hypoalimentationNutrition navigator: http://navigator.tufts.eduAmerican Dietetics Association:http://www.eatright.orgHealthy People: of nutrients (essential, transfatty acids, cholesterol)Nutrients, Vitamins, Minerals and Dietary InformationCholesterol Management Health Center-WebMD malnutritionNutritional Disorders IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  19. 19. Vitamin deficiencies and/or toxicities DEFICIENCY SYMPTOMSMineral deficiencies and toxicities disorders (eg, obesity, anorexia, bulimia) (excellent notes) 2. TEMPERATURE REGULATION 3. ADAPTATION TO ENVIRONMENTAL EXTREMES (including occupational exposures)Physical and associated disorders (eg, temperature; radiation; burns; decreased atmosphericpressure; high altitude sickness; increased water pressure)Trauma and Environmental Injury.html notes (eg, gases, vapors; smoke inhalation; agricultural hazards, volatile organic solvents,heavy metals; principles of poisoning and therapy) II DraftIND/6-3-9c(chem)HumanHealth.doc 4. HOMEOSTASIS: Fluid, electrolyte, and acid-base balance and disorders (eg, dehydration,acidosis, alkalosis) IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  20. 20. COMPONENT IX: INTRODUCTORY PHARMACOLOGY: PHARMACOKINETIC & PHARMACODYNAMIC PRINCIPLES Pharmacokinetics is the study of what the body does to a drug. Pharmacodynamics is the study of what a drug does to the body. and effect.9.1. GENERAL PRINCIPLESMedical Pharmacology 2000 General Principles--Introduction Pharmacokinetics PharmacodynamicsGeneral Principles of Medicinal Chemistry.html notes (selected pharmacologic agents notes)Pharmacokinetics: absorption, distribution, metabolism, excretion, dosage intervalsPharmacokinetics Tutorial of drug action, structure-activity relationships, receptors, signal transduction and dose-effect relationships (eg, efficacy, potency), types of agonists andantagonists and their actionsDrug Receptor InteractionsIndividual factors altering pharmacokinetics and pharmacodynamics (eg, age, gender, disease,tolerance, compliance, body weight, metabolic proficiency, pharmacogenetics)Absorption, distribution, metabolism and excretion.ppt(excellent on factors influencing absorption, distribution etc.)IVMS-General Principles of Pharmacology-Pharmacokinetics and PharmacodynamicsDrug side effects, overdosage, toxicology issues (eg, drug development, approval, scheduling) IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  21. 21. 2. GENERAL PROPERTIES OF AUTOCOIDS (including peptides and analogs, biogenic amines, prostanoids and their inhibitors, and smooth muscle/endothelial autacoids), Pulmonary and Renal Autocoids .PDF. 3. GENERAL PRINCIPLES OF AUTONOMIC PHARMACOLOGYAutonomic IntroductionAutonomic Medicinal Chemistry.htm (neurotransmitters) 4. GENERAL PROPERTIES OF ANTIMICROBIALS (including mechanisms of action and resistance) Antibacterial Agents 5. GENERAL PROPERTIES OF ANTI-NEOPLASTIC AGENTS, IMMUNOSUPPRESSANTS Chemotherapy: Introduction & General Principles Immunopharmacology COMPONENT X: BIOSTATISTICS AND EPIDEMIOLOGY (QUANTITATIVE METHODS) This component explains the elements of measures, types of measures and basic epidemiologic concepts & principles namely, risk ratio, relative risk, odds ratio, incidence, prevalence, association, sensitivity, specificity, predictive values etc. Study designs, and hypothesis testing & statistical inference are both discussed in detail, in allowing for adequate interpretation of medical literature.10.1. ELEMENTS OF MEASUREMENT (excellent links)Scales of measurement IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  22. 22. Distribution, centraltendency, variability, probability prevalence and incidence outcomes (eg, fatality rates) Notes.htmAssociations (correlation or covariance) impact (eg, risk differences and ratios), specificity, predictive values (predictive values) STUDY DESIGNS (discusses meta-analysis)Types of experimental studies (eg, clinical trials, community intervention trials) IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global
  23. 23. Types of observational studies (eg, cohort, case-control, cross-sectional, case series,community surveys)Sampling and sample size (PPT simplified on sampling) selection and exposure allocation (eg, randomization, stratification, self-selection,systematic assignment)Outcome…………assessment and external validity 10.3. HYPOTHESIS TESTING AND STATISTICAL INFERENCEConfidence intervals (95% CI) significance and type I error (simplified) power and type II error (detailed) (simplified)Designed,Developed and Curated by Marc Imhotep Cray,M.D.Please report broken links IVMS BMS GENERAL PRINCIPLES USMLE WEB MAPS-Global