How do drugs work?

Dr. Francisco Pérez García
Departament de Farmacologia
Donat el caràcter i la finalitat exclusivament docent i eminentment
il·lustrativa de les explicacions a classe d'aquesta p...
The term pharmacology comes from the Greek words:
•pharmakon - drug or medicine
•logos - the truth about or a rational dis...
A synthesis of several biomedical sciences….

Pharmacology

…but unique in its own right
Pharmacologists Study Science at Every Level
(2α,4α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-13-{[(2R,3S)- 3-(benzoylamino)2-hydroxy-3-phenylpropanoyl]oxy}- 1,7-dihydroxy-9-...
FROM AMINOACIDS TO PROTEIN DRUG RECEPTORS
RELATIONSHIP BETWEEN PROTEIN STRUCTURE AND FUNCTION
Function relies on interactions with other molecules
Binding of molecu...
Kd = Kon/Koff = [D][R]/[DR]
Ka = 1/Kd = Koff/Kon =
[DR]/[D][R]
Induced fit model vs lock and key model
ACKNOWLEGMENTS
The project «Contemporary Sciences and Research» (2012-2014)
belongs to the Integrated Plan for Foreign Lan...
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
How do drugs work?
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How do drugs work?

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Science Week 2013 Activity
Centre Cultural de Martorell
Integrated Plan for Foreign Languages
Institut Pompeu Fabra

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How do drugs work?

  1. 1. How do drugs work? Dr. Francisco Pérez García Departament de Farmacologia
  2. 2. Donat el caràcter i la finalitat exclusivament docent i eminentment il·lustrativa de les explicacions a classe d'aquesta presentació, l’autor s’acull a l’article 32 de la Llei de Propietat Intel·lectual vigent respecte de l'ús parcial d'obres alienes com ara imatges, gràfics o altre material contingudes en les diferents diapositives
  3. 3. The term pharmacology comes from the Greek words: •pharmakon - drug or medicine •logos - the truth about or a rational discussion
  4. 4. A synthesis of several biomedical sciences…. Pharmacology …but unique in its own right
  5. 5. Pharmacologists Study Science at Every Level
  6. 6. (2α,4α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-13-{[(2R,3S)- 3-(benzoylamino)2-hydroxy-3-phenylpropanoyl]oxy}- 1,7-dihydroxy-9-oxo-5,20-epoxytax11-en-2-yl benzoate = TAXOL A LITTLE BIT OF CHEMISTRY AND A LITTLE BIT OF BOTANY
  7. 7. FROM AMINOACIDS TO PROTEIN DRUG RECEPTORS
  8. 8. RELATIONSHIP BETWEEN PROTEIN STRUCTURE AND FUNCTION Function relies on interactions with other molecules Binding of molecules to proteins is reversible LOCK AND KEY THEORY Ligand = molecule bound reversibly by a protein Binding site = site on protein where ligand binds HIV protease + drug inhibitor
  9. 9. Kd = Kon/Koff = [D][R]/[DR] Ka = 1/Kd = Koff/Kon = [DR]/[D][R]
  10. 10. Induced fit model vs lock and key model
  11. 11. ACKNOWLEGMENTS The project «Contemporary Sciences and Research» (2012-2014) belongs to the Integrated Plan for Foreign Languages of Departament Of Education, Government of Catalonia More info at www.formaciovirtual.com/cs and www.tecnologies.net 52

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