INTRODUCTION TO MLT429
By the end of this module, you should be able to answer the following questions.. and more.. <ul><li>Nucleotides?  Composi...
HISTORY OF MEDICAL GENETICS
Gregor Mendel  1822-1884 <ul><li>An  Austrian scientist  who conducted research in a Czechoslovakian monastery. </li></ul>...
Thomas Hunt Morgan   1866-1945 <ul><li>Drosophilia </li></ul><ul><li>He bred a single  white-eyed  male fly with a  red-ey...
<ul><li>Morgan then bred these male and female  siblings </li></ul><ul><li>Result = some offspring red eyes and some with ...
Francis Harry Compton Crick James Dewey Watson   1916 1928   <ul><li>double helix structure.. </li></ul><ul><li>Explanatio...
 
Biotechnology <ul><li>Stanley Cohen and Herbert Boyer 1973  Recombinant DNA techniques: isolation and amplification of gen...
Upcoming SlideShare
Loading in …5
×

History

490 views

Published on

Published in: Technology
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
490
On SlideShare
0
From Embeds
0
Number of Embeds
11
Actions
Shares
0
Downloads
5
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

History

  1. 1. INTRODUCTION TO MLT429
  2. 2. By the end of this module, you should be able to answer the following questions.. and more.. <ul><li>Nucleotides? Composition? </li></ul><ul><li>Central dogma of genetics ? </li></ul><ul><li>Protein synthesis? </li></ul><ul><li>Mitosis/meiosis? </li></ul><ul><li>Disorders due to genetic variation? </li></ul><ul><li>Sources and conseq of mutations ? </li></ul><ul><li>Current trends in molecular medicine? </li></ul><ul><li>Recombinant DNA technology </li></ul>
  3. 3. HISTORY OF MEDICAL GENETICS
  4. 4. Gregor Mendel 1822-1884 <ul><li>An Austrian scientist who conducted research in a Czechoslovakian monastery. </li></ul><ul><li>Established the basis of modern genetic science. </li></ul><ul><li>Objective = understand how physical traits are passed from a parent to its offspring. </li></ul>                                    
  5. 5. Thomas Hunt Morgan 1866-1945 <ul><li>Drosophilia </li></ul><ul><li>He bred a single white-eyed male fly with a red-eyed female . </li></ul><ul><li>Result = All the offspring produced by this union male/female had red eyes.                            </li></ul>
  6. 6. <ul><li>Morgan then bred these male and female siblings </li></ul><ul><li>Result = some offspring red eyes and some with white </li></ul><ul><li>All of the flies with white eyes were males. </li></ul><ul><li>Theory = genes, arranged on the chromosomes, carry hereditary factors that are expressed in different combinations. </li></ul><ul><li>1933 = Nobel Prize for his discovery of &quot;hereditary transmission mechanisms in Drosophilia .&quot; </li></ul>
  7. 7. Francis Harry Compton Crick James Dewey Watson 1916 1928 <ul><li>double helix structure.. </li></ul><ul><li>Explanation of how the DNA molecule duplicates itself by forming a sister strand to complement each single, ladder-like DNA template. </li></ul><ul><li>1962 Nobel Prize for Physiology or Medicine </li></ul><ul><li>                                   </li></ul>
  8. 9. Biotechnology <ul><li>Stanley Cohen and Herbert Boyer 1973 Recombinant DNA techniques: isolation and amplification of genes, or DNA segments, and insertion them into another cell. </li></ul><ul><li>1982 = researchers produced human insulin : the first commercial application of recombinant DNA technology. </li></ul>

×