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Blood transfusion

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Blood transfusion

  1. 1. *BLOOD TRANSFUSION - Dr.Chintan (9441375293)
  2. 2. * * Blood loss – accidents, surgical operations * Severe anemia (Pregnancy & emergency surgery – quick restoration of Hb) * Exchange transfusion * Blood diseases – Aplastic anemia, agranulocytosis, leukemias, hemophilia, purpura, clotting & bleeding disorders * Acute CO poisoning
  3. 3. * * Donor selection * Cross matching * Major – Donor cell with recipient plasma * Minor – Recipient cells with donor plasma * Universal donor (O –ve) * Universal recipient (AB +ve)
  4. 4. *
  5. 5. * * Chills, rigors, fever, skin rash, itching, urticaria * Anaphylactic shock * Circulatory overload * Iron overload – hemosiderosis * Transmission of diseases, alloimmunization * Infection * Thrombophlebitis * Air embolism * Hyperkalemia * Hypocalcaemia * Hypothermia → cardiac arrest → sudden death
  6. 6. * * Hemolysis – hemoglobinemia & hemoglobinuria (red urine), heart rate ↑, BP ↓, dyspnea, bronchospasm, nausea, vomiting,, pulmonary edema, CCF…………. Jaundice * Chest pain, back pain * Renal stone * Renal shutdown – anuria * Renal vasoconstriction, circulatory shock, kidney tubules blockage * Uremia, Coma, death * TRALI, FNHTR, DHTR, GVHD
  7. 7. * * 1 unit of blood (300 ml) – every 3 months * ACD mixture (21 days) * Cold storage - RBC swell (loss of K, ↑ in Na, water) - 80 % - 24 hrs. – Destroyed at 1% / day - WBCs, Platelets – absent after 24 hrs. * Blood components – PCV, FFP, Platelets
  8. 8. *THANQ……

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