Hepatitis correlation2

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Microscopic features of different types of Hepatitis

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Hepatitis correlation2

  1. 1. GANDAKI MEDICAL COLLEGECORRELATION SEMINAR GI SYSTEM PRESENTED BY: SAJANA BHANDARI SUDARSHAN ACHARYA
  2. 2. OBJECTIVE TO DESCRIBE THE MICROSCOPIC FEATURES OF DIFFERENT TYPES OF HEPATITIS
  3. 3. HEPATITISIt is the inflammationof liver .Usually 2 types: VIRAL HEPATITIS NON-VIRAL HEPATITIS
  4. 4. VIRAL HepatitisHepatitis A – Infectious hepatitisHepatitis B – Serum hepatitisHepatitis C – Non-A non-B or Post transfusion hepatitisHepatitis D – associated with Hep BHepatitis E - Epidemic hepatitis
  5. 5. NON-Viral hepatitis Staph aureus (toxic shock) Gram-Negative (Cholangitis) Parasitic (liver fluke) Amoeba (abscesses) AUTOIMMUNE ALCOHOLIC HEPATITIS
  6. 6. MORPHOLOGY OF ACUTE AND CHRONIC HEPATITISAcute HepatitisHepatocyte injuryHepatocyte necrosisRegenerative changesSinusoidal cell reactive changesPortal tracts changes
  7. 7. 1.Hepatocyte injuryDiffusedswelling(ballooning degeneration)Cholestasis:canalicular bileplugHCV: Focal fattychanges of
  8. 8. 2.Hepatocyte necrosis Isolated cellsCytolysis orApoptosisBridgingnecrosis(portal-portal , central –central, portal –portal)Lobulardisarray: loss ofnormalarchitecture
  9. 9. 5.Portal tracts: Mixture ofinflammatory cells:mainlymononuclearInterfacehepatitis
  10. 10. 3.Regenerative changes:  hepatocyte proliferation 4.Sinusoidal cell reactive changes: Accumulation of phagocytosed cellular debris in kupffer cells  Hypertrophy and hyperplasia of Kupffer cells
  11. 11. Chronic hepatitis Like acute hepatitis has similar; Hepatocyte injury,necrosis , regeneration, sinusoidal cell reactive changes  Portal tract changes Inflammatio Fibrosis n
  12. 12. “Councilman” Bodies
  13. 13. FIBROSIS • Hallmark: deposition of fibrous tissue 1 • HBsAg: “Ground – glass 2 hepatocytes” • HCV infection: Lymphoid aggregation and Bile duct damage 3
  14. 14. Fibrosis of liver
  15. 15. Fulminant Hepatitis
  16. 16. Fulminant Hepatitis Hepatic insufficiency leading to hepatic encephalopathyHistology: 2 formsA) Submassive necrosis Orderly regeneration Partial necrosis usually in centrilobular and mid zone Collapsed reticulin framework
  17. 17. B)Massive necrosis • Necrosis of entire lobule • Loss of hepatic parenchyma • Collapsed and condensed reticulin framework • Disordered regeneration • Fibrosis doesn’t occur
  18. 18. ANY …. ….. ….. ….. ……. Queries...?
  19. 19. THANK U !!!!!

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