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In this work, a novel finite element model using the mechanical homogenization techniques of the human annulus fibrosus (AF) is proposed to accurately predict relevant moduli of the AF lamella for tissue engineering application. A general formulation for AF homogenization was laid out with appropriate boundary conditions. The geometry of the fibre and matrix were laid out in such a way as to properly mimic the native annulus fibrosus tissue’s various, location-dependent geometrical and histological states. The mechanical properties of the annulus fibrosus calculated with this model were then compared with the results obtained from the literature for native tissue. Circumferential, axial, radial, and shear moduli were all in agreement with the values found in literature. This study helps to better understand the anisotropic nature of the annulus fibrosus tissue, and possibly could be used to predict the structure-function relationship of a tissue-engineered AF.