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Dr. Phil Mollica on Ozone in Dentistry

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Dr. Phil Mollica on Ozone use in Dentistry for the AFDC spreecast

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Dr. Phil Mollica on Ozone in Dentistry

  1. 1. AMERICAN COLLEGE OF INTEGRATIVE MEDICINE AND DENTISTRY 
 PRESENTS OXYGEN/OZONE THERAPY IN DENTISTRY
  2. 2. FUNDAMENTAL SCIENTFIC FACTS ABOUT OXYGEN/OZONE UNIVERSITY OF HAVANA, CUBA DEPARTMENT OF PHARMACOLOGY PROF. OLGA SONIA LEON FERNANDEZ VIENNA, OCT. 8 -10, 2011 *DISINFECTION PROPERITES *NON-TOXIC WOUND CLEANING *IMPROVED AND ACCERATED WOUND HEALING
  3. 3. FUNDAMENTAL SCIENTFIC FACTS ABOUT OXYGEN/OZONE UNIVERSITY OF HAVANA, CUBA DEPARTMENT OF PHARMACOLOGY PROF. OLGA SONIA LEON FERNANDEZ VIENNA, OCT. 8 -10, 2011 +ACTIVATION OF RED BLOOD CELL METABOLISM WITH IMPROVED OXYGEN RELEASE +ACTIVATION OF ENZYMATIC ANTIOXIDANTS AND RADICAL SCAVENGERS
  4. 4. FUNDAMENTAL SCIENTFIC FACTS ABOUT OXYGEN/OZONE *ACTIVATION OF IMMUNOCOMPETENT CELLS AND RELEASE OF CYTOKINES SUCH AS INTERFERONES AND INTERLEUKINS. MODULATION OF THE IMMUNE SYSTEM UNIVERSITY OF HAVANA, CUBA DEPARTMENT OF PHARMACOLOGY PROF. OLGA SONIA LEON FERNANDEZ VIENNA, OCT. 8 -10, 2011
  5. 5. FUNDAMENTAL SCIENTFIC FACTS ABOUT OXYGEN/OZONE UNIVERSITY OF HAVANA, CUBA DEPARTMENT OF PHARMACOLOGY PROF. OLGA SONIA LEON FERNANDEZ VIENNA, OCT. 8 -10, 2011 *INCREASED ANTIOXIDANT CAPACITY THROUGH ACTIVATION OF CELLULAR ANTIOXIDANT SYSTEMS CATALASE, SUPEROXIDE DISMUTATSE CATALASE
  6. 6. FUNDAMENTAL SCIENTFIC FACTS ABOUT OXYGEN/OZONE *ANTIINFLAMMATORY EFFECT *INCREASED CIRCULATIONVIA NITRIC OXIDE *HIGH REDOX POTENTIAL
  7. 7. WHAT IS OZONE ?
  8. 8. • A chemical compound consisting of three oxygen atoms (O3). • The elemental form of oxygen occurring naturally as a result of ultraviolet energy or lightning causing a temporary recombination of oxygen atoms into groups of three. • The form of oxygen that is formed by an electric discharge field of a corona discharge generator (simulates lightning). • Oxygen is the only gas that can accept and carry an electrical charge. Remember, the terminal electron acceptor.
  9. 9. HOW IS OZONE CREATED?
  10. 10. OXYGEN AND A ENERGY SOURCE
  11. 11. A MEDICAL GRADE OXYGEN FED COLD CORONA DISCHARGE OZONE UNIT
  12. 12. AND SEARCH “OZONE DENTISTRY” PubMed US National Library of Medicine National Institutes of Health Search term Search database All DatabasesPubMedProteinNucleotideGSSESTStructureGenomeBioProjectBioSampleBioSystemsBooksConserved DomainsClonedbGaPdbVarEpigenomicsGeneGEO DataSetsGEO ProfilesHomoloGeneMeSHNCBI Web SiteNLM CatalogOMIAOMIMPMCPopSetProbeProtein ClustersPubChem BioAssayPubChem CompoundPubChem SubstancePubMed HealthSNPSRATaxonomyToolKitToolKit ozone dentistry Search RSSSave searchLimitsAdvanced Help Display Settings: Summary,20 per page,Sorted by Recently Added << First< PrevPage 1 of 10Next >Last >> Results: 1 to 20 of 191 1. Treatment of Root Canal Biofilms of Enterococcus faecalis with Ozone Gas and Passive Ultrasound Activation. Case PD, Bird PS, Kahler WA, George R, Walsh LJ. J Endod. 2012 Apr;38(4):523-6. Epub 2012 Feb 2. PMID: 22414842 [PubMed - in process] Related citations 2. Ozone therapy in dentistry: A strategic review. Saini R. J Nat Sci Biol Med. 2011 Jul;2(2):151-3. PMID: 22346227 [PubMed - in process] Free PMC Article 191 articles
  13. 13. PRIMARY ISSUES IN DENTISTRY • TRAUMA • INFECTION • BACTERIAL • FUNGAL • VIRAL • PARASITIC
  14. 14. These infections can be: • Acute • Chronic • Bacterial • Viral • Fungal • Parasitic • OR… A some combination of the above • And RESISTANT to current therapeutics
  15. 15. IntegrativeTreatment Regimens • Antibiotics • Antifungals • Antivirals • Antiparasitics • Antiseptics • Essential Oils/Plant Extracts • Homeopathics • Lasers • Ultraviolet Light • Oxygen/Ozone Therapies
  16. 16. All of these regimens have proven to be effective in the treatment of infections
 BUT…
  17. 17. MOST OFTHE REGIMENS HAVE 
 SIGNIFICANT SIDE EFFECTS
 EXCEPT…
  18. 18. OXYYGEN/OZONETHERAPY
  19. 19. Multitude of resources for use in human treatment.
 
 When used at a therapeutic level
 

  20. 20. DOSE AND LANGUAGE USE FOR 
 OZONETHERAPY IN DENTISTRY • EXPRESSED AS MICROGRAMS PER MILLILITERS OF OXYGEN (mcg/ml) • ALSO EXPRESSED AS “GAMMA” • INTERNAL USE RANGE: 6 - 30µg/ml (dependent on application) • EXTERNAL USE RANGE: 40- 50µg/ml (root canal therapy & caries) • **START with a LOW dose and GO SLOW***
  21. 21. What Treatment Regimens will
 Effectively Eliminate: • BACTERIA • VIRUSES • FUNGI • PARASITES
  22. 22. 1. Bacteria 2. Ozone contacts cell membrane 3. Ozone (peroxides) penetrates cell membrane 4. Rupture of cell membrane begins 5. Membrane loses integrity 6. Bacteria lyses due to ozone
  23. 23. OZONE IS PRODUCED BY ANTIBODIES DURING BACTERIAL KILLING IN INFLAMMATION
 THE SCRIPPS RESEARCH INSTITUTE
 NOVEMBER 18, 2002
 LERNER,WENTWORH ET AL. SCIENCE 

  24. 24. WHITE BLOOD CELLS/
 PLASMA CELLS/
 ANTIBODIES
  25. 25. OXIDATION /BIOFILM The cover story in “THE JOURNAL OFTHE AMERICAN DENTAL ASSOCIATION,” Vol 140, No 8 978-986 is “Periodontitis:An Archetypical Biofilm Disease” It states that “Periodontitis is a classic example of biofilm-mediated diseases.” The article concluded that,“Periodontitis, like other biofilm infections, is refractory to antibiotic agents and host defenses because the causative microbes live in complex communities that persist despite challenges that range from targeted antibiotic agents to phagocytosis.” The clinical implications concluded that “The regular delivery of non targeted anti-biofilm agents may be an effective strategy for treating biofilms, especially if these agents include oxidative agents that dissolve the biofilm matrix.” OZONE OXIDIZES / DESTROYS BIOFILM
  26. 26. BIOFILM DISEASES • Periodontal Disease • Carious Disease • Endodontic Disease • Post Extraction • Implant Issues
  27. 27. CurrentTherapies in Dentistry • Caries (tooth decay) • Infection of head and neck • Periodontal Disease • Root CanalTherapy • Enhanced wound healing (post-surgical) • Soft tissue lesions
  28. 28. ISTHIS A LOCAL OR SYSTEMIC PROBLEM?
  29. 29. BOTH!!!
  30. 30. Pulp Exposure?
  31. 31. Deep Caries? What’s under sealants?
  32. 32. ARRESTMENT OF CARIES
  33. 33. THE CASE FOR PIT AND FISSUE SEALENTS WITH OXYGEN/OZONE
  34. 34. 60 second exposure 46µg/cc
  35. 35. 2 minutes post exposure
  36. 36. 46 micrograms/cc – 60 second exposure
  37. 37. OZONE
  38. 38. ENDODONTIC REALITY
  39. 39. FUMIGATION PROCEDURE WITH 40 – 50 µg/cc EACH ROOT EXPOSURE TIME 40-60 SEC.
  40. 40. A “Dry Socket”?
  41. 41. Periodontal Problems?
  42. 42. CODE #162
  43. 43. TWO MONTHS OFTREATMENT
 DR. JOSE DE CASTRO-COIMBRA
  44. 44. History of Ozone CHRISTIAN FREDRICH SCHONBEIN DISCOVERED OZONE IN 1840
  45. 45. • 1881- John Harvey Kellogg, MD, from Battle Creek, MI used ozone to treat diptheria. • 1896- Nikola Tesla patented first O3 generator and sold them to doctors for medical use. • 1898- Benedict Lust, MD, New York- Founder of Naturopathy, wrote about ozone therapy.
  46. 46. 1885 Florida Medical Association
 Published: Ozone • Written by Charles J. Kenworthy M.D. • Practicing medicine in Jacksonville, Florida. • Proved that ozone was in regular medical usage in the United States before 1885. • Therefore, it predates the 1906 Pure Food and Drug Act and the FDA. • Ozone for medical usage is grandfathered in the United States, and held perfectly legal for use without censure.
  47. 47. Ozone History in Dentistry • 1932 - E.A. Fisch, a dentist uses ozonated water in dental procedures and pioneered its use in medicine. (1932-1998 rise and fall of antibiotics) • 1998 - Edward Lynch publishes a series of articles investigating the efficacy of ozone on dental infection. • 1998 – Mollica, Harris first introduced to oxygen/ozone therapy in dentistry to United States • 2000 – Harris delivers first comprehensive oxygen/ozone lecture at Capital University of Integrative Medicine. • 2000 – Oxygen/Ozone becomes curriculum based at CUIM. • 2000 – Oxygen/Ozone Therapy in Dentistry introduced in the clinical setting at National Integrative Health Associates – CUIM clinic • 2002 – Mollica, Harris Oxygen-Ozone Therapy “Applications in Biologic Dentistry”. Presented at first continuing education on oxygen/ozone in dentistry
  48. 48. • 2004 – Edward Lynch – chief editor – Ozone: The Revolution in Dentistry • 2007 – Mollica, Harris Cyto-Immunologic Nutritional Supportive Therapies for Oxygen/Ozone Therapy • 2008 – International Academy of Oral Medicine and Toxicology accepts Oxygen/Ozone Therapy in Dentistry as scientifically valid. • 2008 – IAOMT scientifically validates endodontic therapy with oxygen/ozone (G. Cole) • 2009 – IAOMT publishes Oxygen/Ozone in Dentistry • 2009 – Academy of General Dentistry introduces subject code 162 – Ozone Therapy
  49. 49. THE
 SCIENCE
 OF 
 OZONETHERAPY CORONA DISCHARGE
  50. 50. Properties of Ozone InVitro (ExVivo) Powerful Oxidizer –Kills bacteria, fungi and viruses at lower concentrations than chlorine (1 molecule of ozone = 3,000 to 10,000 molecules of chlorine) AND kills 3500 times faster than chlorine. ●Also oxidizes phenolics (poisonous compounds of methanol and benzene), pesticides, detergents, chemical manufacturing wastes and aromatic compounds more rapidly and effectively than chlorine, yet WITHOUT chlorine’s harmful residues (Trihalomethanes, etc.).
  51. 51. Important Aspect to Consider *AGAIN* Oxygen/Ozone can accept AND Carry an electrical charge Biofilm, Bacteria,Virus, Fungi, Parasites, Infection and Inflammation all are positively charged Ozone has a negatively charged area
  52. 52. The In Vivo 
 Therapeutic Oxidative
 BURST 0Z0NE PLASMA REACTIVE OXYGEN SPECIES ROS (early phase) LIPID OXIDATION PRODUCTS LOPs (late phase) O3 H2O2 O1
  53. 53. –Ozonated Water: Ozone gas is bubbled through water, creating a solution that has a shelf life of 10 hours at room temperature and 5 days in the refrigerator. Ozonated water is used to treat: • Wounds • Burns • Intestinal problems • Slow healing skin infections • Gynecological Infections • Also used for colonics • and enemas
  54. 54. – Ozonated Oil (primarily olive oil): Ozone is bubbled through oil until it forms a salve/balm type consistency. This is used to treat: • Skin conditions, infections with bacteria, fungi and viruses. • Hemorrhoids • Vulvovaginitis • Insect bites/bee stings • Gingivitis • Placed on capsules and ingested to treat ulcers, gastritis and giradiasis
  55. 55. TMD Applications FOLLOW “Standard of Care Procedures” IF symptoms fail to resolve THEN consider ozone treatment due to the probability of an infection/inflammation in the joint(s) or chronic inflammation of ligaments, tendons, muscles or ganglia
  56. 56. THE SCIENCE/RESEARCH OF OXYGEN/OZONE
 ALLOWS FOR…….!!! • NON-TOXIC SAFE AND EFFECTIVE APPLICATION • TRUE BIOLOGIC AGENT • MINIMALTO NO SIDE EFFECTS • ECONOMICTHERAPY
  57. 57. IN A BIOLOGIC SENSE……. • THE CREATION OF A THERAPEUTIC OXYGEN/OXIDATIVE “BURST” WHICH INDUCES A MULTI-FACTORIAL BIOCHEMICAL/ PHYSIOLOGIC RESPONSE THERE BY REVERSING A STATE OF ANAEROBIOSIS CONTAINED WITHIN THE AFFLICTED TISSUES….MOLLICA OTTO WARBURG
  58. 58. INTEGRATION OF OZONETHERAPY INTO DAILY BIOLOGIC DENTAL PRACTICE
  59. 59. NASAL INSUFFLATION
  60. 60. +O3 C10H18O3 TRIOZONIDE OF TRIOLEIN NOT AN OXIDANT OXIDATION OF OLIVE OIL 
 SO WHAT’STHE POINT?
 

  61. 61. – Inhalation of Ozonides: An ozone/oxygen mixture is bubbled through olive oil and gaseous compounds are created that are a species of triozonides of triolein (C10H18O3) that are safe to inhale. These triozonides decompose at the aqueous level of the lung alveolus. The thereby create oxidative peroxides that are used to treat: Allergies Asthma Other respiratory diseases Sinus infections Foundational procedure THE CREATION OF AROMATIC TERPENES!
  62. 62. BIOFILM An aggregate of microbes with a distinct colonizing architecture.
  63. 63. LUNG ALVEOLUS
 WITH BIOFILM FORMATION
 DYSFUNCTIONAL CILIA DUE TO MICROBIAL TOXINS FROM BIOFILM
  64. 64. EAR INSUFFLATION: 
 THE OXYGEN/OZONE BEING DELIVEREDTOTHETYMPANIC MEMBRANE MUST BE MOISTENED PRIORTO CONTACT! MOISTURE CAN BE DELIVERED VIA BUBBLING OXYGEN/OZONE THROUGH THE OZONATED WATER SNAKE OR MOISTENED AT THE CUPS OF THE STETHOSCOPE WITH WET GAUZE (use a fan to blow the gas away from the face)
  65. 65. Ear Infections
 (German Research) 17 patients received 15 sessions of rectal ozone plus ozonized oil drops for chronic suppurative O.M. 16 tested negative at the end of two cycles, and 14 improved their hearing loss. Mastoid x-ray improvement noted in 13. Another study remarked on the improvement noted using O2/O3 irrigations of theTM. This is the preferred therapy for recurrent otitis media as opposed to repeated and prolonged use of antibiotics.
  66. 66. • Vestn Otorinolaringol. 2009;(3):34-5. • [Treatment of patients with acute and chronic suppurative middle ear diseases using ozone preparations]. • [Article in Russian] • Sin'kov EV. • Abstract • Methods of clinical application of gaseous ozone and ozonated solutions are described with special reference to the treatment of patients with acute and chronic suppurative middle ear diseases. Results of otoscopy, microbiological and cytological studies confirm therapeutic efficiency of the above techniques as accelerating recovery of patients with this pathology. It is recommended to include ozonotherapy as an additional method in the combined treatment of acute and chronic suppurative otitis media. It is recommended to include ozonotherapy as an additional method in the combined treatment of acute and chronic suppurative otitis media.
  67. 67. Vestn Otorinolaringol. 1999;(2):48-9. [Reasons for the application of medical ozone in the treatment of chronic purulent mesotympanitis]. [Article in Russian] Shakov VIu, Edeleva AN. Abstract Ozone-oxygen mixture (ozone concentration 600 microg/l) was used in irrigations of the tympanic cavity in 52 patients with chronic purulent mesotympanitis (CPM). The course of the treatment consisted of 5-7 procedures. 18 CPM controls received standard treatment without the irrigations. The course of the ozone-oxygen irrigations produced good results: ear discharge and tympanic mucosa inflammation stopped in 81% of the irrigated patients, levels of myeloperoxidase which marks inflammation reduced significantly, bactericidal effects of the mixture were observed for all the detected pathogens, antibiotic sensitivity of the bacteria rose. Fast antiinflammatory result of ozone therapy was due not only to its bactericidal effect but also via its antihypoxic and immunomodulating mechanisms Fast antiinflammatory result of ozone therapy was due not only to its bactericidal effect but also via its antihypoxic and immunomodulating mechanisms
  68. 68. MULTI-TONSILULAR FORMS
  69. 69. TONSIL-FASCIA SPACE INFUSION TECHNIQUE • PRINCIPLE PART OF COMPREHENSIVE LYMPHATIC THERAPY • PURPOSE: TO DRAIN AND DISENFECT THE TONSILS, SURROUNDING FASCIA AND SOFT TISSUE(RETRO- PHARYNGEAL SPACE) • 6 TO 10µg/cc in syringe with 30g 1”needle • Insert needle up to hub through tonsil. • Slowing start infusion at the same time, slowly retract. This will dispense oxygen/ozone throughout area. • Infusion a total of 1 – 2cc per side • Expectations: 24 – 72 hours drainage and possible outbreak of pus-like lesions. This is good and will remediate within a few days.
  70. 70. ONE INFUSION 2-3CC AT 6 - 10µG/CC
  71. 71. QUESTIONS??

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