Inflammation ospe rapid review

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Inflammation ospe rapid review general pathology

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Inflammation ospe rapid review

  1. 1. INFLAMMATION - OSPE RAPID REVIEW A N By bbas aseem abbas_naseem@yahoo.com
  2. 2. “ Education is a progressivediscovery of our own ignorance ” Will Durant
  3. 3. First A look @ Slides from BIG ROBIN – 8th edition
  4. 4. Nature of leukocyte infiltrates in inflammatory reactions. The photomicrographs are representative of the early (neutrophilic) (A) and later (mononuclear) cellular infiltrates (B) seen in an inflammatory reaction in the myocardium following ischemic necrosis (infarction).
  5. 5. The characteristic histopathology of acute inflammation.A, Normal lung shows thin (virtually invisible) blood vessels in the alveolar walls and no cells in the alveoli.B, The vascular component of acute inflammation is manifested by congested blood vessels (packed with erythrocytes), resulting from stasis.C, The cellular component of the response is manifested by large numbers of leukocytes (neutrophils) in the alveoli.
  6. 6. Serous inflammation.Low-power view of a cross-section of a skin blister showing the epidermis separated from the dermis by a focal collection of serous effusion.
  7. 7. Fibrinous pericarditis.A, Deposits of fibrin on the pericardium.B, A pink meshwork of fibrin exudate (F) overlies the pericardial surface (P).
  8. 8. Purulent inflammation.A, Multiple bacterial abscesses in the lung, in a case of bronchopneumonia.B, The abscess contains neutrophils and cellular debris, and is surrounded by congested blood vessels.
  9. 9. The morphology of an ulcer.A, A chronic duodenal ulcer.B, Low-power cross-section of a duodenal ulcer craterwith an acute inflammatory exudate in the base.
  10. 10. Chronic inflammation in the lung, showing all three characteristic histologic features:(2) collection of chronic inflammatory cells (*),(2) destruction of parenchyma (normal alveoli are replaced by spaces lined by cuboidal epithelium, arrowheads),and replacement by connective tissue (fibrosis, arrows). B, By contrast, in acute inflammation of the lung (acute bronchopneumonia), neutrophils fill the alveolar spaces and blood vessels are congested.
  11. 11. A focus of inflammation showing numerous eosinophils. (orange red/dark granules)
  12. 12. Typical tuberculous granuloma showing an area of central necrosis surrounded by multiple Langhans- type giant cells, epithelioid cells, and lymphocytes.
  13. 13. Now …. Exclusive Other Slides for OSPE Preparation(including Slides from Robins Pathology)
  14. 14. Lymphocyte, neutrophil nd plasma cell
  15. 15. Monocyte
  16. 16. Eosinophil(orange red/dark granules), lymphocyte
  17. 17. Basophil(densely granular)
  18. 18. Eosinophil neutrophil Lymphocyte BasophilMonocyte
  19. 19. Neutrophil Margination 21
  20. 20. Vascular changes
  21. 21. Pneumonia - Exudation
  22. 22. Lymphocytes and macrophages
  23. 23. Macrophages in infarcted brain:
  24. 24. Plasma cells
  25. 25. Lymphocytes around a blood vessel:
  26. 26. Lymphoid follicles:
  27. 27. Granulomas seen in lung
  28. 28. Suppurative or purulent inflammation ischaracterized by the production of large amountsof pus or purulent exudate consisting ofneutrophils, necrotic cells, and edema fluid.
  29. 29. Serous inflammation is marked by theoutpouring of a thin fluid that, depending onthe size of injury, is derived from either theplasma or the secretions of mesothelial cellslining the peritoneal, pleural, and pericardialcavities (called effusion).
  30. 30. FIBRINOUS INFLAMMATIONWith more severe injuries and the resultinggreater vascular permeability, larger moleculessuch as fibrinogen pass the vascular barrier, andfibrin is formed and deposited in theextracellular space
  31. 31. An ulcer is a local defect, or excavation, of thesurface of an organ or tissue that is produced bythe sloughing (shedding) of inflammatorynecrotic tissue
  32. 32. -------- eXclusive OSPE PICS -------- acute inflammationThe redness corresponds to the rubor of acute inflammation and calor (heat)is due to histamine-dependent arteriolar vasodilatation.Pain (dolor) in acute inflammation is due to bradykinin and PGE2
  33. 33. Leukocyte-margination andpavementing
  34. 34. Neutrophils in acute inflammation
  35. 35. Monocytes
  36. 36. Cell number 1 is an eosinophil.Cell number 2 is a basophil.
  37. 37. Granulomatous inflammationNote the presence of multinucleated giant cells. Also note that lymphocytes predominate in the areas surrounding the granuloma.
  38. 38. Granulomatous inflammation: Langhans giant cellNote that the nuclei are arranged at the periphery of the cell. This is a characteristic of Langhans giant cells. These cells are prominent in areas of granulomatous inflammationbut are not required for a diagnosis.
  39. 39. Abscess brain - Acute inflammation
  40. 40. Fibrinous pericarditis – Acute Inflammation
  41. 41. Purulent meningitis – Acute Inflammation
  42. 42. Pulmonary tuberculosis - chronic inflammation
  43. 43. Pulmonary tuberculosis - chronic inflammation
  44. 44. Pulmonary tuberculosis (detail 2)
  45. 45. Chronic inflammation Tuberculous lymphadenitis (tuberculous granuloma)
  46. 46. Tuberculous lymphadenitis (tuberculous granuloma)Detail -1
  47. 47. Tuberculous lymphadenitis (tuberculous granuloma)Detail - 2
  48. 48. Chronic Inflammation Foreign body granuloma
  49. 49. “ The whole art of teaching isonly art of awakening the naturalcurosity of young minds for thepurpose of satisfying itafterwards ” Anatole France
  50. 50. Lymphocytic inflitration and the formation of non-caseating granuloma
  51. 51. Giant Cell
  52. 52. Touton Giant Cell
  53. 53. foreign body type giant cell
  54. 54. foreign body type giant cell
  55. 55. foreign body type giant cell
  56. 56. Abscess formation lung , gross
  57. 57. Acute and chronic inflammation , microscopic
  58. 58. Chronic inflammation with destruction ofbronchial wall , microscobic
  59. 59. Chronic inflammation with scarring , bronchus ,Gross
  60. 60. chronic interstitial inflammation lung ,microscobic
  61. 61. Erythema,Gross
  62. 62. exudate (pseudomemberanous enterocolitis),gross
  63. 63. Exudation microscopic
  64. 64. Exudation of fibrin, Microscopic
  65. 65. Fibrinous exudate pericardium ,gross
  66. 66. Fibrinous exudate pericardium ,microscopic
  67. 67. foamy macrophage 1
  68. 68. foamy macrophage 2
  69. 69. foamy macrophage 3
  70. 70. foamy macrophage 4
  71. 71. Inflammation with necrosis high powermicroscopic
  72. 72. Inflammation with necrosis low powermicroscopic
  73. 73. Margination &diapedesis of neutrophil ,Microscopic
  74. 74. Microscopic Neutrophilia
  75. 75. Ulceration , gastreic mucosa , Gross
  76. 76. Ulceration esophagus , microscobic
  77. 77. Ulceration larynx , Gross
  78. 78. macrophage phagocytosis
  79. 79. THE ENDTHANK YOU “ Yesterday I dared to struggle Today I dare to win ” Bernadette Devlin For Comments & Suggestions abbas_naseem@yahoo.com Abbas Naseem Dated: April 3, 2010

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