INFLAMMATION - OSPE RAPID REVIEW A N By bbas aseem email@example.com
“ Education is a progressivediscovery of our own ignorance ” Will Durant
First A look @ Slides from BIG ROBIN – 8th edition
Nature of leukocyte infiltrates in inflammatory reactions. The photomicrographs are representative of the early (neutrophilic) (A) and later (mononuclear) cellular infiltrates (B) seen in an inflammatory reaction in the myocardium following ischemic necrosis (infarction).
The characteristic histopathology of acute inflammation.A, Normal lung shows thin (virtually invisible) blood vessels in the alveolar walls and no cells in the alveoli.B, The vascular component of acute inflammation is manifested by congested blood vessels (packed with erythrocytes), resulting from stasis.C, The cellular component of the response is manifested by large numbers of leukocytes (neutrophils) in the alveoli.
Serous inflammation.Low-power view of a cross-section of a skin blister showing the epidermis separated from the dermis by a focal collection of serous effusion.
Fibrinous pericarditis.A, Deposits of fibrin on the pericardium.B, A pink meshwork of fibrin exudate (F) overlies the pericardial surface (P).
Purulent inflammation.A, Multiple bacterial abscesses in the lung, in a case of bronchopneumonia.B, The abscess contains neutrophils and cellular debris, and is surrounded by congested blood vessels.
The morphology of an ulcer.A, A chronic duodenal ulcer.B, Low-power cross-section of a duodenal ulcer craterwith an acute inflammatory exudate in the base.
Chronic inflammation in the lung, showing all three characteristic histologic features:(2) collection of chronic inflammatory cells (*),(2) destruction of parenchyma (normal alveoli are replaced by spaces lined by cuboidal epithelium, arrowheads),and replacement by connective tissue (fibrosis, arrows). B, By contrast, in acute inflammation of the lung (acute bronchopneumonia), neutrophils fill the alveolar spaces and blood vessels are congested.
A focus of inflammation showing numerous eosinophils. (orange red/dark granules)
Typical tuberculous granuloma showing an area of central necrosis surrounded by multiple Langhans- type giant cells, epithelioid cells, and lymphocytes.
Now …. Exclusive Other Slides for OSPE Preparation(including Slides from Robins Pathology)
Suppurative or purulent inflammation ischaracterized by the production of large amountsof pus or purulent exudate consisting ofneutrophils, necrotic cells, and edema fluid.
Serous inflammation is marked by theoutpouring of a thin fluid that, depending onthe size of injury, is derived from either theplasma or the secretions of mesothelial cellslining the peritoneal, pleural, and pericardialcavities (called effusion).
FIBRINOUS INFLAMMATIONWith more severe injuries and the resultinggreater vascular permeability, larger moleculessuch as fibrinogen pass the vascular barrier, andfibrin is formed and deposited in theextracellular space
An ulcer is a local defect, or excavation, of thesurface of an organ or tissue that is produced bythe sloughing (shedding) of inflammatorynecrotic tissue
-------- eXclusive OSPE PICS -------- acute inflammationThe redness corresponds to the rubor of acute inflammation and calor (heat)is due to histamine-dependent arteriolar vasodilatation.Pain (dolor) in acute inflammation is due to bradykinin and PGE2
Cell number 1 is an eosinophil.Cell number 2 is a basophil.
Granulomatous inflammationNote the presence of multinucleated giant cells. Also note that lymphocytes predominate in the areas surrounding the granuloma.
Granulomatous inflammation: Langhans giant cellNote that the nuclei are arranged at the periphery of the cell. This is a characteristic of Langhans giant cells. These cells are prominent in areas of granulomatous inflammationbut are not required for a diagnosis.