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David J. Howe - Resume                                         Wayland, Massachusetts 01778                               ...
David J. Howe (508) 397-5371•   Provide a complete installation record for each deployment.•   Coordinate required user tr...
David J. Howe (508) 397-5371Managed Projects•   Migrated three hundred and fifty research computers from Windows 2000 to W...
David J. Howe (508) 397-5371    potential studies for a Joint Development Project Proposal for Intel exploring the effect ...
David J. Howe (508) 397-5371EDUCATION  PHD                                         MS                                     ...
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David J. Howe - Resume/CV - Lab Informatics Chemist - - djh94001


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David J. Howe - Resume/CV - Lab Informatics Chemist - - djh94001

  1. 1. David J. Howe - Resume Wayland, Massachusetts 01778 Cell: 508.397.5371 Home: 508.655.1172 plus years experience in high-throughput, GLP, R&D and pharmaceutical labs and informationsystems. Excellent communicator, particularly with chemists and engineers. Ability to construct clear,concise documentation for non-technical, scientific and regulatory audiences. Self-starting professionalwith a natural interest in learning, solving problems and helping people. Strong knowledge of: • Design, validation and support of scientific applications • Chemistry and chemical analysis • Specialty chemical development and troubleshooting Industries: Pharmaceuticals, Specialty Chemicals, Research and Development, Manufacturing Skills: Lab Informatics, Web Applications, Oracle, NuGenesis SDMS, Waters MassLynx, Millennium32 and Empower, Cambridgesoft ChemOffice, ChemInventory and ELN, Spotfire, Pipeline Pilot, MDL ISIS Desktop, Accelrys Accord Enterprise, Symyx Arthur eNotebook, Chemstation, TotalChrom, Sciex Analyst, Softmax Pro, LabX direct, TOAD, Axure, MS Office (Word, Excel, PowerPoint, Outlook) , Lotus Notes, Visio, MS Windows, TCP/IP, VB Script, Windows Script, Basic, Analytical Chemistry, Electrochemistry, ChromatographyPROFESSIONAL EXPERIENCE WATERS CORPORATION 2010 - present ENTERPRISE SUPPORT SERVICES – CONTRACT CONSULTANT Informatics Technical Support Specialist Responsible for the implementation and maintenance of Waters’ informatics products in their internal Milford, Massachusetts and Regional Labs. Assist the labs with the effective use of these tools in both their day to day operations as well as in demonstrations for visiting external customers. Lab Data Managemment and Workflow Automation • Gather User Requirements for each desired data management or workflow automation solution: Determine and document the data generation, use and management profile for each lab deployment of Nugenesis SDMS. Design appropriate metadata extraction templates and archive schedule. Elicit and document lab workflow and notebook documentation processes. Design Nugenesis Vision Publisher templates for the desired automation of these operations. • Configure and deploy the required software, servers and workstations. Page 1 of 5
  2. 2. David J. Howe (508) 397-5371• Provide a complete installation record for each deployment.• Coordinate required user training with the Training Manager.• Manage data collection and archival from Empower chromatography data systems.• Coordinate with the lab managers and staff for planed additions and modifications to the lab equipment or processes that are supported by the Informatics products. Update informatics configurations as required.Implementation Procedure Development• Develop and document Implementation Methods and Procedures for Informatics Product Releases.• Provide the Support Team with detailed documentation that can be used to troubleshoot problems.• Provide support to outside customers, System Engineers and the Sales Team.BROAD INSTITUTE OF HARVARD AND MIT 2007 - 2010CHEMICAL BIOLOGY PLATFORMBusiness Analyst/Application Engineer III Worked closely with chemists, biologists and software engineers to translate user requirements into Oracle based LIMS systems for managing the production, distribution, quality control and screening of small molecule libraries. Gathered requirements, designed and prototyped web based application UIs, and planned and executed validations. Provided training and support, and documented and resolved software issues.Analytical Laboratory Informatics• Designed, delivered and supported informatics enabling compound library QC and purification.• Integrated Waters NuGenesis SDMS with the Broad’s Chemical Biology Informatics Platform, enabling presentation and annotation of LC-MS QC data by chemists.• Maintained and administered the SDMS system in coordination with IT support and DBAs. Compound Management Informatics• Designed, delivered and supported data management systems that ensure compounds and plates associated with screens are adequately tracked and made available to project teams.• Facilitated analytical compound quality assessment.• Participated in configuration, validation, documentation and deployment of new systems.BIOGEN IDEC 2006 - 2007RESEARCH INFORMATICS SUPPORT – CONTRACT CONSULTANTChemistry Application Support SpecialistSupported Chemistry and Laboratory Informatics• Coordinated all aspects of chemistry application evaluation projects. Tested applications prior to version and equipment upgrades.• Coordinated application installations and upgrades remotely and on site.• Analyzed and troubleshot problems encountered by chemists related to vendor and custom software applications. Followed through on issues to ensure that they were resolved to the end user’s satisfaction.• Coordinated with IT, vendors and researchers on instrument computer software support and upgrades.• Maintained all required system and support documentation and records.• Managed license and maintenance contracts for supported applications. Page 2 of 5
  3. 3. David J. Howe (508) 397-5371Managed Projects• Migrated three hundred and fifty research computers from Windows 2000 to Windows XP. Project Lead.• Developed Automated Software Inventory System for Research in Cambridge, Massachusetts and San Diego, California. Project Lead.• Upgraded Waters Millennium32 chromatography software to Empower 2. Coordinated with vendor and lab researchers.• Upgraded Symantec Antivirus on all laboratory computers. Coordinated with IT.Charles River Laboratories 2004 - 2006PRE-CLINICAL SERVICESScientific Systems AdministratorImproved Efficiency of Systems Implementation and Support• Eliminated seventy item back log in approximately nine months while improving turn around times for ongoing support by formalizing a process to coordinate and track internal, IT and QA projects supporting Bioanalytical systems.• Provided management with metrics for objective decision support.• Designed and initiated pre-validation software selection and evaluation process resulting in improved supportability of non-GLP systems and reduced validation cycle time for GLP.• Initiated formal specification and documentation of systems availability and security requirements, design and monitoring.Evaluated and Implemented (GLP) Informatics Systems• Lead member of administrative teams responsible for the specification, installation and validation of all of the bioanalytical departments scientific software systems.• Team members included Senior Management, the Validation Group, Engineers, QA and the IT department.• Coordinated user, functional and security requirements assessments.• Formulated IQ/OQ processes and documentation.• 21 CFR Part 11 Compliance Assessments.Administered Applications• Responsibilities included account maintenance, performance and security monitoring, problem reporting and resolution, change control and SOP maintenance.ROHM AND HAAS ELECTRONIC MATERIALS 1996 - 2004ANALYTICAL SERVICES GROUPAnalytical Chemist• Conducted analytical investigations utilizing GC, GC-MS, Pyrolysis and Headspace GC, HPLC, FTIR, UV- Vis, Thermal Analysis, electron microscopy and wet chemical methods in support of R&D, Quality Control and Customer Service - full line of microelectronic and circuit board manufacturing chemistries.• Maintained instrument hardware and software.• Designed, executed and statistically evaluated measurement capability studies using JMP• Electrochemical Research - Dual Damascene program support involved voltammetric and open circuit Page 3 of 5
  4. 4. David J. Howe (508) 397-5371 potential studies for a Joint Development Project Proposal for Intel exploring the effect of complexing agents on Cu/Zn alloy plating.Lab InformaticsProvided informatics solutions for Corporate Research and Development• Collaborated with Corporate Library Services to develop and pilot test a wireless Lotus Notes based electronic laboratory notebook.• Enhanced efficiency and effectiveness of analytical lab operations, optimized space utilization and retention of information content and enhanced chemical communications.• Developed analytical services sample request and workflow system using Visual Basic.• Migrated sample request workflow system to Lotus Notes.• Worked with consultants, Valid Systems, to include email based reporting, automated report archiving and version control.• Implemented hard drive image repository for lab instruments computers using Norton Ghost.• Automated lab data archival in accordance with a three year record retention policy.• Enabled bi-directional data transfer between business and lab networks.• Installed and configured Galactic Grams32/ Spectral DB Server for both lab and business network access.• Established galactic SPC format as standard for raw data delivery.• Facilitated analytical reporting and presentation.• Developed applications allowing any windows based instrument to print data and reports directly to PDF, WMF or BMP formats.Developed applications for instrument control and data analysis• Developed cyclic voltammetry simulation and fitting application using BASIC.• Automated control of PAR M273 Potentiostat and Galvanostat using Headstart Script.• Developed graphical process and measurement capability analysis tool using JMP Script.Designed and implemented laboratory networking standard• Designed corporate standard TCP/IP laboratory network for Windows and Macintosh data systems.• Designed firewall interface between lab and business networks.• Installed six R&D and quality control lab networks.• Responsible for interfacing new instrumentation to the analytical services network.• Coordinated virus protection updates for lab networks.• Enabled corporate email, Lotus Notes and internet access at all lab computers.Corporate knowledge management• Led cross functional team to develop corporate intranet subject index using Lotus Notes.• Participated on team to develop first corporate public web site using Lotus Notes Domino.• Participated in scientific knowledge management at the corporate level.• Championed and developed “Tech Talk” Lotus Notes discussion database for R&D. Page 4 of 5
  5. 5. David J. Howe (508) 397-5371EDUCATION PHD MS BS Chemistry Chemical Engineering Chemistry and Physical Sciences University of Connecticut Tufts University Trinity College Storrs, CT Medford, MA Hartford, CTHONORS Connecticut High Technology Scholarship for outstanding graduate work in chemistry, awarded by State of Connecticut President of Chemistry Honor Society, UCONN Chapter of Phi Lambda Upsilon Krieble Scholarship (Trinity) - full tuition scholarship for outstanding work in chemistry, awarded by Loctite Corporation Division of Analytical Chemistry of the American Chemical Society Undergraduate Award Page 5 of 5