FIGURE 1Localization of gonadotropinreleasing hormone (GnRH) in theretina. Schematic illustration of aretinal cross section shows threeparallel layers of cell nucleiseparated by two plexiform layers.A, B, C Immunohistological stainingof fibers containing.
FIGURE 2GnRH receptor type 1 expressionpattern in the retina. A In situhybridization with a probe againstGnRH-R1 mRNA revealed that a smallpercentage of cells in the amacrinecell layer with a sparse distributionexpress GnRH-R1 as shown by densely.
FIGURE 3Tyrosine hydroxylase-positive cells in theretina. A Whole-mounted retinashowing cellsimmunoreactive fortyrosine hydroxylase(red). Cells weredistributed across theretina within theamacrine layer in asomewhat regularpattern. Bar = 100μm.
FIGURE 4GnRH receptor type 2expression in theretina. A In situhybridization toGnRH-R2 mRNA revealedwidespread expressionin the ganglion celllayer (GCL). BNegative controlshows no signalpattern. INL = Innernuclear layer; ONL =outer nuclear layer.
FIG URE 5Th e ore tical m od e l ofG nR H e ffe cts in re tinalcircu itry. G nR Hre ach e s typ e 1re ce p tors ind op am ine rgic ce lls(D A) of th e am acrinece ll laye r and typ e 2re ce p tors in ganglionce lls (G ). Arrowsind icate th e d ire ction ofinform ation b e twe e n