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Center for Research and Development of Light-Activated Materials Daniel Engebretson, Director
Light-Activated Research <ul><li>Definition: </li></ul><ul><ul><li>Materials or Processes that are produced or enabled by ...
Light-Activated Materials <ul><li>Examples of Light-Activated Materials already in the Marketplace: </li></ul><ul><ul><li>...
Collaborators – Institutions
Senior Researchers <ul><li>USD Chem/Physics </li></ul><ul><ul><li>Dan Engebretson </li></ul></ul><ul><ul><li>Mary Berry </...
Solar Energy – Opportunity <ul><li>Photovoltaics, the direct conversion of sunlight to electricity, is the ONLY identified...
Solar Energy <ul><li>Teaming with Researchers from SDSU and SDSMT </li></ul><ul><li>Problem – Much of the solar spectrum u...
Photocatalysis – Opportunity <ul><li>Rapidly Expanding Market </li></ul><ul><li>Opportunities in: </li></ul><ul><ul><li>Bu...
Photocatalysis <ul><li>Problem – Most Applications Require Ultraviolet Light </li></ul><ul><li>2010 Solution – Design New ...
Detectors and Sensors <ul><li>In vitro diagnostics market >$20 billion in 2005 </li></ul><ul><li>Nucleic Acid Testing to g...
Detectors – Opportunity <ul><li>Problem – Most diagnostic tests require highly skilled technicians and specialized equipme...
Bioadhesives – Opportunity  <ul><li>“ In the next five to 10 years, surgical tissue  ADHESIVES  will be delivered which wi...
Bioadhesives <ul><li>Problem – Current Bioadhesives are either toxic or weak </li></ul><ul><li>2010 Solution – Design new ...
Bioadhesives Research <ul><li>Formulation Set for FDA Approval </li></ul><ul><li>Identified New Variants </li></ul><ul><ul...
Bioadhesives – Applications  <ul><li>Ophthalmology </li></ul><ul><ul><li>LASIK </li></ul></ul><ul><ul><li>Tethering Drugs ...
Commercial – PhotoBioMed  <ul><li>Licensed in South Dakota </li></ul><ul><li>Biotech Company Incorporated in Texas </li></...
Outcomes – Jobs Created <ul><li>*Daniel Engebretson, USD Chemistry </li></ul><ul><ul><li>Director CRDLM </li></ul></ul><ul...
Intellectual Property <ul><li>Andrew Sykes – USD Chemistry </li></ul><ul><ul><li>Filed Disclosure on Luminescent Sensors f...
Outcomes – Grant Activities <ul><li>Eight Research Grants Awarded </li></ul><ul><ul><li>3 Related to Energy </li></ul></ul...
Outcomes – NPURC  <ul><li>NSF – Northern Plains Undergraduate Research Center </li></ul><ul><li>7 Regional Colleges and Un...
NPURC – Goals  <ul><li>Revise Curricula at Regional Schools </li></ul><ul><ul><li>Introduce students to research early in ...
2010 and Beyond <ul><li>Annual Revenue ~$2 Million </li></ul><ul><li>11 New Academic Jobs </li></ul><ul><ul><li>1 New Facu...
South Dakota People  <ul><li>Dan Engebretson, Director </li></ul><ul><li>Kaia Kloster, USDSM/Avera </li></ul><ul><li>Laura...
CRDLM/Community <ul><li>Help Develop Innovative Applications </li></ul><ul><ul><li>Sugar production </li></ul></ul><ul><ul...
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  1. 1. Center for Research and Development of Light-Activated Materials Daniel Engebretson, Director
  2. 2. Light-Activated Research <ul><li>Definition: </li></ul><ul><ul><li>Materials or Processes that are produced or enabled by light </li></ul></ul><ul><li>Fields: </li></ul><ul><ul><li>Energy – Solar, Hydrogen </li></ul></ul><ul><ul><li>Photocatalysis – Environmental Remediation </li></ul></ul><ul><ul><li>Detectors and Sensors – Environmental, Biomedical </li></ul></ul><ul><ul><li>Bioadesives – Wound Healing, Drug Delivery </li></ul></ul><ul><li>Goal: </li></ul><ul><ul><li>Create businesses and jobs based on our technology </li></ul></ul>
  3. 3. Light-Activated Materials <ul><li>Examples of Light-Activated Materials already in the Marketplace: </li></ul><ul><ul><li>Energy – solar powered calculators, watches, etc. </li></ul></ul><ul><ul><li>Photocatalysts – anti-fog glass, self-cleaning glass, etc. </li></ul></ul><ul><ul><li>Detectors and Sensors – medical assays (diagnostics), hazardous materials </li></ul></ul><ul><ul><li>Healthcare </li></ul></ul><ul><ul><ul><li>Bioadhesives – UV cure resins in dentistry </li></ul></ul></ul><ul><ul><ul><li>Photodynamic Therapy – acne, cancer </li></ul></ul></ul>
  4. 4. Collaborators – Institutions
  5. 5. Senior Researchers <ul><li>USD Chem/Physics </li></ul><ul><ul><li>Dan Engebretson </li></ul></ul><ul><ul><li>Mary Berry </li></ul></ul><ul><ul><li>James Hoefelmeyer </li></ul></ul><ul><ul><li>Ranjit Koodali </li></ul></ul><ul><ul><li>Stan May </li></ul></ul><ul><ul><li>Grigoriy Sereda </li></ul></ul><ul><ul><li>Yongchen Sun (Phys.) </li></ul></ul><ul><ul><li>Andrew Sykes </li></ul></ul><ul><li>USDSM </li></ul><ul><ul><li>Kaia Kloster (Avera) </li></ul></ul><ul><ul><li>Gudiseva Chandrasekher </li></ul></ul><ul><li>SDSU Chemistry </li></ul><ul><ul><li>Ron Utecht </li></ul></ul>
  6. 6. Solar Energy – Opportunity <ul><li>Photovoltaics, the direct conversion of sunlight to electricity, is the ONLY identified technology that can meet all four criteria: </li></ul><ul><ul><li>Affordable </li></ul></ul><ul><ul><li>Reliable </li></ul></ul><ul><ul><li>Secure </li></ul></ul><ul><ul><li>Sustainable </li></ul></ul><ul><li>AND satisfy WORLD electricity demand…. </li></ul>-Smalley and Lewis, IEEE PVSC Jan. 2005
  7. 7. Solar Energy <ul><li>Teaming with Researchers from SDSU and SDSMT </li></ul><ul><li>Problem – Much of the solar spectrum unused </li></ul><ul><li>2010 Solution – Design new molecules to “funnel” the solar spectrum </li></ul>
  8. 8. Photocatalysis – Opportunity <ul><li>Rapidly Expanding Market </li></ul><ul><li>Opportunities in: </li></ul><ul><ul><li>Building Materials </li></ul></ul><ul><ul><li>Air Purification </li></ul></ul><ul><ul><li>Sterilization </li></ul></ul>Image Copyright PPG, Inc.
  9. 9. Photocatalysis <ul><li>Problem – Most Applications Require Ultraviolet Light </li></ul><ul><li>2010 Solution – Design New Materials that Utilize Visible Light </li></ul>
  10. 10. Detectors and Sensors <ul><li>In vitro diagnostics market >$20 billion in 2005 </li></ul><ul><li>Nucleic Acid Testing to grow from $2.25 billion in 2004 to $6.5 billion in 2009 </li></ul>Nucleic Acid Testing, Navigant Consulting, 2004
  11. 11. Detectors – Opportunity <ul><li>Problem – Most diagnostic tests require highly skilled technicians and specialized equipment </li></ul><ul><li>2010 Solution – Design and develop test kits that require minimal skills and common equipment </li></ul>
  12. 12. Bioadhesives – Opportunity <ul><li>“ In the next five to 10 years, surgical tissue ADHESIVES will be delivered which will REVOLUTIONIZE the art of surgery by replacing sutures in the majority of operations performed in the country… the age of commercially produced, effective surgical adhesives is now arriving in the US.” </li></ul>-- Dr. William Spotnitz, Director of the Tissue Adhesive Center at the Virginia Health Sciences Center, 2000
  13. 13. Bioadhesives <ul><li>Problem – Current Bioadhesives are either toxic or weak </li></ul><ul><li>2010 Solution – Design new Bioadhesives that are Safe and Strong </li></ul>
  14. 14. Bioadhesives Research <ul><li>Formulation Set for FDA Approval </li></ul><ul><li>Identified New Variants </li></ul><ul><ul><li>Ability to “Tune” Bond Strength </li></ul></ul><ul><li>Investigate Chemical Mechanisms </li></ul><ul><ul><li>Understanding  Applications </li></ul></ul><ul><li>Good Manufacturing Practices (GMP) </li></ul><ul><ul><li>Essential for in vitro Studies </li></ul></ul>
  15. 15. Bioadhesives – Applications <ul><li>Ophthalmology </li></ul><ul><ul><li>LASIK </li></ul></ul><ul><ul><li>Tethering Drugs </li></ul></ul><ul><li>Dermatology </li></ul><ul><li>General Surgery </li></ul><ul><li>Cardiology </li></ul><ul><li>Orthopedics </li></ul>
  16. 16. Commercial – PhotoBioMed <ul><li>Licensed in South Dakota </li></ul><ul><li>Biotech Company Incorporated in Texas </li></ul><ul><li>Role: Identify Industry Partners </li></ul><ul><li>Bioadhesives Research Conducted in SD </li></ul><ul><li>Participated in World’s Best Technology Competition in Dallas, TX </li></ul><ul><li>Won Governor Round’s Giant Vision Business Plan Competition </li></ul><ul><ul><li>PhotoBioMed Corporation TM : Strong and Safe Medical Adhesives TM </li></ul></ul>
  17. 17. Outcomes – Jobs Created <ul><li>*Daniel Engebretson, USD Chemistry </li></ul><ul><ul><li>Director CRDLM </li></ul></ul><ul><li>*Gudiseva Chandrasekher, USDSM </li></ul><ul><ul><li>Ophthalmologic Applications of Bioadhesives </li></ul></ul><ul><li>Ranjit Koodali, USD Chemistry </li></ul><ul><ul><li>Photoactivated Catalysis for Environmental Remediation </li></ul></ul><ul><li>*James Hoefelmeyer, USD Chemistry. </li></ul><ul><ul><li>Catalytic Activity of Metal Nanoparticles </li></ul></ul><ul><li>*Laura Koepsell, SDSU Chemistry </li></ul><ul><ul><li>2004 USD Chemistry Graduate (B.S.) </li></ul></ul>* New Position
  18. 18. Intellectual Property <ul><li>Andrew Sykes – USD Chemistry </li></ul><ul><ul><li>Filed Disclosure on Luminescent Sensors for Lead Detection Based on a Novel Photodynamic Mechanism </li></ul></ul><ul><li>Kloster and Utecht – USDSM/Avera and SDSU </li></ul><ul><ul><li>Filed Disclosure on Alternative Chemical Formulations for Tissue Bonding </li></ul></ul>
  19. 19. Outcomes – Grant Activities <ul><li>Eight Research Grants Awarded </li></ul><ul><ul><li>3 Related to Energy </li></ul></ul><ul><ul><li>2 Related to Photocatalysis </li></ul></ul><ul><ul><li>1 Related to Photodynamic Cancer Therapy </li></ul></ul><ul><ul><li>2 Related to Undergraduate Research (Photodynamics and Synthesis) </li></ul></ul><ul><li>5 Different Principal Investigators </li></ul><ul><li>Total value of awards nearly $3 Million </li></ul><ul><li>Many others submitted and planned </li></ul><ul><li>Teaming with 2010 Center for Accelerated Applications at the Nanoscale for SD EPSCoR </li></ul>
  20. 20. Outcomes – NPURC <ul><li>NSF – Northern Plains Undergraduate Research Center </li></ul><ul><li>7 Regional Colleges and Universities </li></ul><ul><ul><li>University of South Dakota (Vermillion, SD) </li></ul></ul><ul><ul><li>Mount Marty College (Yankton, SD) </li></ul></ul><ul><ul><li>Augustana College (Sioux Falls, SD) </li></ul></ul><ul><ul><li>Sinte Gleska University (Rosebud Reservation, Mission, SD) </li></ul></ul><ul><ul><li>Fort Berthold Community College (Tribal College, New Town, ND) </li></ul></ul><ul><ul><li>Buena Vista University (Storm Lake, IA) </li></ul></ul><ul><ul><li>Dordt College (Sioux Center, IA) </li></ul></ul>
  21. 21. NPURC – Goals <ul><li>Revise Curricula at Regional Schools </li></ul><ul><ul><li>Introduce students to research early in their academic careers </li></ul></ul><ul><li>Intensive Undergraduate Research </li></ul><ul><ul><li>Summer research experiences for undergraduates </li></ul></ul><ul><li>Engage High School Science Teachers </li></ul><ul><ul><li>Better prepare high school students for college </li></ul></ul><ul><li>Prepare Graduates to Participate in Tech-based Economy (Local or National) </li></ul><ul><ul><li>Graduates are resources rather than products </li></ul></ul>
  22. 22. 2010 and Beyond <ul><li>Annual Revenue ~$2 Million </li></ul><ul><li>11 New Academic Jobs </li></ul><ul><ul><li>1 New Faculty </li></ul></ul><ul><ul><li>10 New Postdoctoral Fellows/Research Scientists </li></ul></ul><ul><li>3 Small Businesses Started </li></ul><ul><ul><li>Small Business Innovative Research </li></ul></ul><ul><ul><li>10-15 New Jobs </li></ul></ul><ul><li>Royalty and License $ from Bioadhesives </li></ul>
  23. 23. South Dakota People <ul><li>Dan Engebretson, Director </li></ul><ul><li>Kaia Kloster, USDSM/Avera </li></ul><ul><li>Laura Koepsell, SDSU Chemistry </li></ul>
  24. 24. CRDLM/Community <ul><li>Help Develop Innovative Applications </li></ul><ul><ul><li>Sugar production </li></ul></ul><ul><ul><li>Feedlots </li></ul></ul><ul><li>Provide Conducive Atmospheres to Small Businesses </li></ul><ul><ul><li>Encourage citizenry to become “tech aware” </li></ul></ul><ul><ul><li>Libraries and Schools </li></ul></ul>

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