Research Funding: Navigating the NIH Grant

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Research Funding: Navigating the NIH Grant

  1. 1. Research Funding: Navigating the NIH Grant Maze Special thanks: Marianna Bledsoe, M.A. Resources Development Branch Cancer Diagnosis Program, National Cancer Institute
  2. 2. NIH Structure <ul><li>27 Institutes and Centers (ICs) </li></ul><ul><ul><li>Institutes </li></ul></ul><ul><ul><ul><li>e.g. National Cancer Institute, National Heart, Lung, and Blood Institute, National Institute of Dental and Craniofacial Research , National Institute of Neurological Disease and Stroke, National Institute of Biomedical Imaging and Bioengineering </li></ul></ul></ul><ul><ul><li>Centers: </li></ul></ul><ul><ul><ul><li>e.g. Center for Scientific Review (CSR); National Center for Research Resources </li></ul></ul></ul>
  3. 3. Who’s Who <ul><li>Review Staff </li></ul><ul><ul><li>Center for Scientific Review (CSR) or Institute/Center staff- these are the people who can answer general questions </li></ul></ul><ul><ul><li>Responsible for receipt, referral and review of applications </li></ul></ul><ul><li>Program Staff </li></ul><ul><ul><li>Responsible for the scientific funding and oversight of grants </li></ul></ul>
  4. 4. What is NIH Looking For ? <ul><li>The best science </li></ul><ul><li>Expertise and resources to get it done </li></ul><ul><li>Who Can Get One? </li></ul><ul><ul><li>Any qualified scientist with academic credentials and experience appropriate to the application </li></ul></ul><ul><ul><li>Institution is the grantee (exceptions: fellowships and career rewards) </li></ul></ul><ul><ul><li>Shared responsibilities </li></ul></ul><ul><ul><li>Domestic or Foreign </li></ul></ul>
  5. 5. Updates on Budget 2003 <ul><li>Continuous resolution funding levels low </li></ul><ul><ul><li>NCI: </li></ul></ul><ul><ul><ul><li>New Investigator RO1 17% </li></ul></ul></ul><ul><ul><ul><li>Continued grant RO1 17% </li></ul></ul></ul><ul><ul><ul><li>New initiatives RO1 12% </li></ul></ul></ul><ul><li>2003 Senate and House Approved Budget </li></ul><ul><ul><li>$27.3 billion to NIH (16.2% increase over 2002) </li></ul></ul>
  6. 6. Types of NIH Grants <ul><li>Training Grants </li></ul><ul><li>Investigator-Initiated </li></ul><ul><ul><li>Regular Research Grant: R01 </li></ul></ul><ul><ul><li>Program Project Grant: P01 </li></ul></ul><ul><ul><li>Specialized Programs of Research Excellence (SPORE) </li></ul></ul><ul><ul><li>Other </li></ul></ul><ul><ul><li>Small Business </li></ul></ul><ul><ul><ul><li>Innovative Research Grant (SBIR) </li></ul></ul></ul><ul><ul><ul><ul><li>R43, R44 </li></ul></ul></ul></ul><ul><ul><ul><li>Technology Transfer Research (STTR) </li></ul></ul></ul><ul><ul><ul><ul><li>R41, R42 </li></ul></ul></ul></ul>
  7. 7. Keep up with NIH Initiatives <ul><li>Initiatives </li></ul><ul><ul><li>Used by Institutes and Centers to stimulate research in particular areas </li></ul></ul><ul><ul><li>Announced in NIH Guide </li></ul></ul><ul><ul><ul><li>http://grants.nih.gov/grants/guide/index.html </li></ul></ul></ul><ul><ul><li>Program Announcements </li></ul></ul><ul><ul><ul><li>No set aside, Usually reviewed by CSR </li></ul></ul></ul><ul><ul><ul><li>Exploratory Grants R21 </li></ul></ul></ul><ul><ul><ul><li>R21/R33 </li></ul></ul></ul>
  8. 8. The Application Process <ul><ul><li>PHS 398 for most competing grants </li></ul></ul><ul><ul><li>Instructions critical-don’t miss the deadline </li></ul></ul><ul><ul><li>Special requirements for animals, human subjects, inclusion of women, minorities, and children </li></ul></ul><ul><ul><li>Call appropriate NIH staff or research officers of University for help </li></ul></ul>
  9. 9. … and more Process <ul><li>Receipt and Assignment </li></ul><ul><ul><li>Applications submitted to Center for Scientific Review-Study section organization in process of review and restructure </li></ul></ul><ul><ul><li>Assigned to an IC and an appropriate Scientific Review Group (SRG) </li></ul></ul><ul><li>Initial Peer Review </li></ul><ul><ul><li>Managed by Scientific Review Administrators (CSR or IC staff) </li></ul></ul><ul><ul><li>Generally 3 reviewers, make recommendation and discussed in section if viewed in upper half. </li></ul></ul><ul><ul><li>Some initiatives and grant types have special review process </li></ul></ul>
  10. 10. Understand the system…. <ul><li>Scoring </li></ul><ul><ul><li>Priority scores: </li></ul></ul><ul><ul><ul><li>Each SRG member assigns a score ranging from 1 – 5; </li></ul></ul></ul><ul><ul><ul><li>1 = best; 5 = worst </li></ul></ul></ul><ul><ul><ul><li>Composite score calculated (100 best; 500 worst) </li></ul></ul></ul><ul><ul><li>Percentiles: </li></ul></ul><ul><ul><ul><li>Rank relative to other applications reviewed by SRG at the last three meetings </li></ul></ul></ul><ul><ul><ul><li>Range from .5 (best) to 99.5 (worst) </li></ul></ul></ul>
  11. 11. and the intent of Feedback <ul><li>Summary Statement (the pink sheet) </li></ul><ul><ul><li>Summarizes comments during review process </li></ul></ul><ul><ul><li>Provides an opportunity for revision based on reviewers comments-argue at your own risk! </li></ul></ul><ul><ul><li>will also include a summary of discussion of all members </li></ul></ul><ul><li>Advisory Council/Board Review </li></ul><ul><ul><li>Second level of peer review </li></ul></ul><ul><ul><li>Review applications for human subjects, animal welfare concerns; ensure that initial peer review is appropriate </li></ul></ul><ul><ul><li>Concurrence with initial peer review </li></ul></ul>
  12. 12. IC Funding Decisions <ul><ul><li>Pay lines </li></ul></ul><ul><ul><li>Scientific Merit </li></ul></ul><ul><ul><li>Programmatic Balance </li></ul></ul><ul><ul><li>Budgetary Factors </li></ul></ul><ul><ul><li>Other considerations </li></ul></ul>
  13. 13. You made it! <ul><li>Pre-Award </li></ul><ul><ul><li>IC staff review issues that must be resolved prior to funding </li></ul></ul><ul><ul><ul><li>Human subjects/animal welfare issues </li></ul></ul></ul><ul><ul><ul><li>Inclusion of women, minorities and children </li></ul></ul></ul><ul><ul><ul><li>Scientific overlap </li></ul></ul></ul><ul><li>Award </li></ul><ul><ul><ul><li>Negotiation by grants management staff </li></ul></ul></ul><ul><ul><ul><li>Notice of Grant Award </li></ul></ul></ul><ul><li>Post-Award </li></ul><ul><ul><ul><li>Non-competing continuation (yearly progress reports) </li></ul></ul></ul>
  14. 14. Don’t Forget <ul><li>Follow grant application instructions (PHS398 or other) </li></ul><ul><li>Identify yourself as a new investigator </li></ul><ul><li>If submitting in response to an initiative, address special requirements and specific points listed in the announcement-why is your application meritorious? </li></ul><ul><li>Pay careful attention to the review criteria </li></ul><ul><li>Develop clearly stated hypothesis </li></ul><ul><li>Neatness, spelling and presentation are very important. </li></ul>
  15. 15. Remember to <ul><li>Write clearly and concisely; KISS and FOCUS-your reviewer may not be an expert in your area </li></ul><ul><li>Document resources and institutional support </li></ul><ul><li>Demonstrate solid understanding of literature, strengths and weaknesses methods </li></ul><ul><li>Describe potential pitfalls and alternative approaches </li></ul><ul><li>Bring in collaborators to fill gaps in expertise and resources (document with letters of support) </li></ul>
  16. 16. Helpful Hints <ul><li>Include information essential to the review in the body of the application, not the appendix </li></ul><ul><li>Organize using outline format, numbers per the instructions. Highlight or ital key information so it is not missed. </li></ul><ul><li>Your CV is an opportunity to impress, don’t forget to update it and show a track record of productivity or reasons why not. </li></ul><ul><li>Base the budget on the science; justify and address overlap </li></ul><ul><li>Seek advice and have others read your final draft </li></ul>
  17. 17. Career Track Opportunities
  18. 18. cancer.gov/cancertraining Cancer Training Branch Website
  19. 19. http://cancertraining.nci.nih.gov /

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