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Someone who knows how to cope with innovation and no financial return on investment is Melissa Penny, professor at the Swiss TPH. She shared her insights on finding therapies for neglected diseases, which are often non-profitable. Her approach is to ensure evidence of a new therapeutic or cure for those diseases is “profitable” from a global health perspective. By utilising modelling and simulating as well as data analytics the effectiveness of an intervention throughout the whole value chain can be demonstrated to support payers to make the best decision possible.