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Digital Biomarkers in Neuroscience Research

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At the DayOne Experts - Next Generation Clinical Trials event, Catherine Wu from Roche provided insight into how digital technologies may open up new possibilities for enhancing clinical trials, especially in the field of neurology.

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Digital Biomarkers in Neuroscience Research

  1. 1. Digital Biomarkers in Neuroscience Research Catherine Wu Digital Health Manager F. Hoffmann-La Roche Ltd DayOne Experts - Next Generation Clinical Trials 25th June 2019
  2. 2. Clinical disease activity is the tip of an iceberg Clinical detection MRI detection Accumulation of neurological damage
  3. 3. Generating insights from digital biomarkers Disease insightsH C 0 1 2 3 4 -1 0 1 2 **** Data processing & analysis GPS Magnetometer Touch Sound Light Connectivity Accelerometer Gyroscope Sensors
  4. 4. Lipsmeier, Florian et al. (2018). Evaluation of smartphone-based testing to generate exploratory outcome measures in a phase 1 Parkinson's disease clinical trial: Remote PD Testing with Smartphones. Movement Disorders. 33. 10.1002/mds.27376. Digital biomarkers of Parkinson’s Disease
  5. 5. Three pillars of the Digital Biomarker analysis A D H E R E N C E Patients collect data regularly 01 A G R E E M E N T S e n s o r d a t a c o r r e l a t e s w i t h c l i n i c a l s c a l e s 02 A U G M E N TAT I O N S e n s o r d a t a p r o v i d e s n o v e l i n s i g h t s b e y o n d c l i n i c a l s c a l e s 03
  6. 6. Balancing opportunities and challenges Precision Patient experience Data management
  7. 7. Catherine Wu Digital Health Manager F.Hoffmann-La Roche Ltd catherinemengwu@gmail.com Linkedin.com/in/catherine-meng-wu @Catherine_Wu34

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