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New Genetic Modification Technologies for Stem Cells
Description: XTNTM TALENs Out-cut the Competition- Get the best- Not ...
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New Genetic Modification Technologies for Stem Cells

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XTNTM TALENs Out-cut the Competition- Get the best- Not all Talens are equal. Transposagen uses the superior protein engineering to deliver high performance talens, Enhanced targeting, better high performance, variable repeats and codon optimization make all the difference. Have them fast- we utilize our own XTN high-throughputs production system to deliver your TALENs quikly.More Flexible- XTN Talens have a wide genome targeting range, making any project possible. Results Delivered- Higher efficiencies tranlate to better results. Stay out of trouble- XTN Talens have minimal off-target effects and low toxicity.
Wildtype CRISPR- The good: Inexpensive, fast product, Highly active, Flexible targeting range, Can multiplex. The bad- Very high off-target mutation rates, Some design constrain, Not always active in certain cell types. The Next Generation CRISPR: NextGENTM CRISPR- Cas9 inactivated; clevage activity depends on the dimerzation of Foki, Only true dimeric CRISPR system, Wide target range, but some limits due to spacer and PAM requirements, More complex to design, Multiplex ability, High efficiency (comparable to WT CRISPR).Therapeutic uses of Footprint-FreeTM Gene Editing, Summary- NextGen CRISPR demonstrates good targeting efficency and low to no-off site mutagenesis. piggyBac is extremely efficient at delivering transgenes of any size to stom cells and is completely reversible.

Published in: Health & Medicine
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New Genetic Modification Technologies for Stem Cells

  1. 1. New Genetic Modification Technologies for Stem Cells Description: XTNTM TALENs Out-cut the Competition- Get the best- Not all Talens are equal. Transposagen uses the superior protein engineering to deliver high performance talens, Enhanced targeting, better high performance, variable repeats and codon optimization make all the difference. Have them fast- we utilize our own XTN high-throughputs production system to deliver your TALENs quikly. More Flexible- XTN Talens have a wide genome targeting range, making any project possible. Results Delivered- Higher efficiencies tranlate to better results. Stay out of trouble- XTN Talens have minimal off-target effects and low toxicity. Wildtype CRISPR- The good: Inexpensive, fast product, Highly active, Flexible targeting range, Can multiplex. The bad- Very high off-target mutation rates, Some design constrain, Not always active in certain cell types. The Next Generation CRISPR: NextGENTM CRISPR- Cas9 inactivated; clevage activity depends on the dimerzation of Foki, Only true dimeric CRISPR system, Wide target range, but some limits due to spacer and PAM requirements, More complex to design, Multiplex ability, High efficiency (comparable to WT CRISPR). Therapeutic uses of Footprint-FreeTM Gene Editing, Summary- NextGen CRISPR demonstrates good targeting efficency and low to no-off site mutagenesis. piggyBac is extremely efficient at delivering transgenes of any size to stom cells and is completely reversible. Reference URL: http://medical.wesrch.com/paper-details/pdf-ME1XXFT06FLCM-new-genetic- modification-technologies-for-stem-cells

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