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Focused Ultrasound
DisclosureInSightec board member and shareholder
3  Focused UltrasoundNew, revolutionary, noninvasive therapeutic technologyAlternative or adjunct     Surgery     Radiat...
Essential Tremor
Essential Tremor
Essential Tremor
Essential Tremor
Functional Testing  Before Procedure   After Procedure
Thalamic Lesion Created to Treat Essential Tremor
Uterine Fibroid Treatment     Pre-treatment   MR scan of fibroid
Uterine Fibroid Treatment ComparisonHysterectomy         Focused UltrasoundMajor surgery        Noninvasive, no incisionGe...
Uterine Fibroid Treatment  Pre-treatment                    9 months post-treatment   Nine months after treatment, the fib...
Breast CancerPre treatment   2 weeks post treatment
What is Focused Ultrasound?
Marriage of Two Breakthrough TechnologiesFocused Ultrasound: therapy Treat tissue deep in body   •   Noninvasively   •   ...
Focused UltrasoundAnalogous to a magnifying glass focusing rays of the sun…
Focused UltrasoundMultiple intersectingbeams of ultrasound        Focused with extreme         accuracy        Point: 1 ...
Effects at Focal PointDestroy tissue: thermal ablation, cavitationDeliver drugsDissolve clots: sonothrombolysisRadiation s...
Destroy Tissue: Thermal AblationHeating any tissue to 130 F (56 C) for one secondDestroys any tissue, normal or abnormal.
Focal Drug DeliveryDeliver drugs in high concentrations Precisely where needed Minimizing systemic toxicityDrugs Chermo...
Drugs contained in microbubbles released by ultrasoundonly at the target 1/5
Drugs contained in microbubbles released by ultrasoundonly at the target 2/5
Drugs contained in microbubbles released by ultrasoundonly at the target 3/5
Drugs contained in microbubbles released by ultrasoundonly at the target 4/5
Drugs contained in microbubbles released by ultrasoundonly at the target 5/5
Focused Ultrasound ProcedureSteps in procedure Targeting Planning Treating Confirming
Procedure: Targeting                   Structures               to be avoided                  Region to                  ...
Procedure: Planning              Automatic planning
Procedure: Treatment              Real time guidance                 Temperature                 measurement
FUS Advantages vs Radiation    Single treatment    Immediate and verifiable effect    Greater precision and accuracy  ...
Global Development Landscape
Imagine the Future: 2020Advances in technology    Imaging    Focused ultrasound    Focal drug deliveryUndreamed-of appl...
SNAKE OIL: CURE-ALL33
Limitations: Cannot be used for all conditions       Scoliosis                Leukemia                              Trauma...
Potential Impact, Urgent NeedTechnology widely available    Delay = unnecessary death, disability, suffering    Countles...
Focused UltrasoundFoundation  It’s all about the patients
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Celebration of science final

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FUSF Presentation giving at the Celebration of Science conference.

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Celebration of science final

  1. 1. Focused Ultrasound
  2. 2. DisclosureInSightec board member and shareholder
  3. 3. 3 Focused UltrasoundNew, revolutionary, noninvasive therapeutic technologyAlternative or adjunct  Surgery  Radiation therapy  Drug deliveryEarly stage, MR 25 years ago, additional R&DAs important to therapy as MR is to diagnosesTransform treatment of a variety of serious medical disorders  Benign and malignant tumors  Metastatic cancer  Parkinson’s disease & epilepsy  Back pain, hypertensionReal today, infancy
  4. 4. Essential Tremor
  5. 5. Essential Tremor
  6. 6. Essential Tremor
  7. 7. Essential Tremor
  8. 8. Functional Testing Before Procedure After Procedure
  9. 9. Thalamic Lesion Created to Treat Essential Tremor
  10. 10. Uterine Fibroid Treatment Pre-treatment MR scan of fibroid
  11. 11. Uterine Fibroid Treatment ComparisonHysterectomy Focused UltrasoundMajor surgery Noninvasive, no incisionGeneral anesthesia Conscious sedationPainful Minimal discomfortHospitalization Outpatient6 weeks recovery 1 day recoverySide effects No side effectsNo more children Preserved fertility
  12. 12. Uterine Fibroid Treatment Pre-treatment 9 months post-treatment Nine months after treatment, the fibroid has been absorbed
  13. 13. Breast CancerPre treatment 2 weeks post treatment
  14. 14. What is Focused Ultrasound?
  15. 15. Marriage of Two Breakthrough TechnologiesFocused Ultrasound: therapy Treat tissue deep in body • Noninvasively • Accurately and preciselyMagnetic Resonance (MR) or Ultrasound (US) Imaging Identify and target tissue to be treated Guide and control treatment in real time Immediate confirmation of effectiveness
  16. 16. Focused UltrasoundAnalogous to a magnifying glass focusing rays of the sun…
  17. 17. Focused UltrasoundMultiple intersectingbeams of ultrasound  Focused with extreme accuracy  Point: 1 mm diameter  Deep in bodyIndividual beams pass harmlessly through tissuePoint of convergence: profound effectAdjacent tissue unaffected
  18. 18. Effects at Focal PointDestroy tissue: thermal ablation, cavitationDeliver drugsDissolve clots: sonothrombolysisRadiation sensitizationDrug activity enhancementCoagulate blood vesselsAmplification of cancer biomarkersImmunomodulationNeuromodulationVasodilation Variety of effects, variety of disorders Abundant research opportunities
  19. 19. Destroy Tissue: Thermal AblationHeating any tissue to 130 F (56 C) for one secondDestroys any tissue, normal or abnormal.
  20. 20. Focal Drug DeliveryDeliver drugs in high concentrations Precisely where needed Minimizing systemic toxicityDrugs Chermotherapeutic agents Antibotics Genes Growth factors
  21. 21. Drugs contained in microbubbles released by ultrasoundonly at the target 1/5
  22. 22. Drugs contained in microbubbles released by ultrasoundonly at the target 2/5
  23. 23. Drugs contained in microbubbles released by ultrasoundonly at the target 3/5
  24. 24. Drugs contained in microbubbles released by ultrasoundonly at the target 4/5
  25. 25. Drugs contained in microbubbles released by ultrasoundonly at the target 5/5
  26. 26. Focused Ultrasound ProcedureSteps in procedure Targeting Planning Treating Confirming
  27. 27. Procedure: Targeting Structures to be avoided Region to be treated
  28. 28. Procedure: Planning Automatic planning
  29. 29. Procedure: Treatment Real time guidance Temperature measurement
  30. 30. FUS Advantages vs Radiation  Single treatment  Immediate and verifiable effect  Greater precision and accuracy  Real time localization  No cumulative dose  No limitations on lesion size  No limitations on number of treatments  No secondary tumors  100% cell death  Sharp margins
  31. 31. Global Development Landscape
  32. 32. Imagine the Future: 2020Advances in technology  Imaging  Focused ultrasound  Focal drug deliveryUndreamed-of applications
  33. 33. SNAKE OIL: CURE-ALL33
  34. 34. Limitations: Cannot be used for all conditions Scoliosis Leukemia Traumatic Injuries Lung Tumors
  35. 35. Potential Impact, Urgent NeedTechnology widely available  Delay = unnecessary death, disability, suffering  Countless individuals: friends, family, you!Focused Ultrasound Foundation  Shorten time to wide-spread use  Saving time, saving lives
  36. 36. Focused UltrasoundFoundation It’s all about the patients

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