Northwestern University Cardiovascular MR Imaging Research

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Researchers at Northwestern University shared this presentation and granted permission to CEI to distribute it, helping encourage others to use EnSight for 4D-Flow visualization of transient MRI data.

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Northwestern University Cardiovascular MR Imaging Research

  1. 1. Northwestern CardiovascularMR Imaging Research Departments of Radiology & Biomedical Engineering Northwestern University, Chicago, IL, USA
  2. 2. CV-MRI 4D Flow Flow sensitive 4D Data 3D Visualization• Adaptive navigator respiration control  4D (3D volume + time)• Res. ~ 2mm3, TRes ~ 40ms, TAcq ~ 10-15min flow (3-dir. velocity encoding) MRIMarkl M, et al. JMRI 2007; 25:824-831 Markl M, et al. JCMR 2011; 13:7Frydrychowicz A, et al. J Cardiovasc Magn Reson 2008;10:30
  3. 3. 4D Flow MRIApplications Fluckiger JU, et al. JMRI 2013 Barker AJ, et al. Circ Cardiovasc Imaging 2012:457-466 Markl M, et al. JMRI 2012:1015-1036 Stankovicz Z, et al. Radiology 2012; 262:862-873 Markl M, et al. JCMR 2011; 13:7 Geiger J, et al. Eur Radiol 2011; 21:1651-1657 Markl M, et. al. EJCTS 2011; 39 206-212 Frydrychowicz A, et al. Invest Radiol 2011; 46:317-325 Markl M, et al. Circ Cardiovasc Imaging 2010; 3:647-655 Harloff A, et al. Stroke 2010; 41:1145-1150 Harloff A, et al. MRM 2009; 61:65-74 Carotid arteries Portal vein Stalder AF, et al. MRM 2008; 60:1218-1231 Markl M, et al. JMRI 2007; 25:824-831 Wetzel S, et. al. AJNR 2007; 28:433-438
  4. 4. CV-MRI Thoracic 4D Flow MRI 3D blood flow characteristics in the aortic valve disease m Comprehensive evaluation of hemodynamics 3D flow jet patterns, wall shear stress, pressure m Significantly altered 3D flow and wall parameters Influence of valve morphology on disease progressions Structure-function relationship m Impact of surgical therapy on aortic hemodynamics Barker AJ, et al. Circ Cardiovasc Imaging 2012:457-466
  5. 5. CV-MRI Neurovascular Disease - AVM Arteriovenous malformation (AVM) m 3D visualization of AVM network Complex arterial feeding & venous draining patterns Pre-operative assessment & treatment planning m Intra-cranial blood flow quantification monitoring of treatment induced changes Ansari S, et al. AJNR 2013, in press
  6. 6. CV-MRI Neurovascular Disease - Aneurysm 3D Flow in Intracranial Aneurysms Complex blood flow & wall shear stress patterns inside the aneurysm 2 WSS [N/m] for 2 aneurysm groups 1.20 1.00 velocity [m/s] Group 1 Group 2 0.5 saccular aneurysm fusiform aneurysm 0.80 0.60 0 0.40 0.20 0.00 Mean 0.40 0.04 min 0.07 0.02 max 1.26 0.08 4D hemodynamics in cerebral aneurysms m 3D flow visualization inside the aneurysm Complex blood flow patterns, Impact of flow changes on aneurysm wall m Quantification of altered hemodynamics Correlation of disease progression with regional flow characteristics Risk stratification & treatment planning Schnell S, et al. J Magn Reson Imaging 2013, in press
  7. 7. CV-MRI 4D Flow MRI in CHD Fontan circulation single ventricle extracardiac TCPC Congenital heart Disease: Comprehensive evaluation of flow & anatomy 3D visualization of complex hemodynamics & mixing in CHD Flow pathways in cardiac chambers & vessels Retrospective flow quantification Full 3D coverage, no pre-defined 2D planes Markl M, et al. J Magn Reson Imaging 2012:933–937
  8. 8. CV-MRI 4D Flow MRI in CHD venous & pulmonary flow systemic flow Fontan circulation single ventricle extracardiac TCPC Congenital heart Disease: Comprehensive evaluation of flow & anatomy 3D visualization of complex hemodynamics & mixing in CHD Flow pathways in cardiac chambers & vessels Retrospective flow quantification Full 3D coverage, no pre-defined 2D planes Markl M, et al. J Magn Reson Imaging 2012:933–937
  9. 9. CV-MRI Whole Heart 4D Flow Atrial Fibrillation: Quantification of Left atrial 3D Hemodynamics Comprehensive evaluation of atrial 3D flow 3D visualization of atrial hemodynamics Flow pathways in cardiac chambers Retrospective quantification 3D velocity distribution, flow coherence Fluckiger JU, et al. J Magn Reson Imaging 2013
  10. 10. AcknowledgementsNorthwestern CardiovascularMR Imaging Research Michael Markl, PhD James Carr, MD Susanne Schnell , PhD Alex Barker , PhD Jacob Fluckiger , PhD Kelly Jarvis, BS Can Wu, MS Bradley Allen , MD Julio Garcia Flores , PhD Pim van Ooij , PhD Pegah Entezari , MD Jeremy Collins , MD Zoran Stankovic , MDDepartments of Radiology & Biomedical EngineeringNorthwestern University, Chicago, IL, USA

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