Building AI-Driven Apps Using Semantic Kernel.pptx
I-ironic
1. G. De Micheli,
Q. Huang, L. Thoeny-Meyer, Y. Leblebici,
C. Dehollain, F. Grassi, S. Carrara
Implantable/Wearable System for
on-line Monitoring
of Human Metabolic Conditions
(Implantable-IRONIC)
2. Implanted devices for monitoring
In/Out tubing
Almost only for diabetes A. Menarini Diagnostics, Florence
Almost only for glucose
GlucoDay® and GlucoMenDay® consist of a micro-pump
and a biosensor coupled to a micro-dialysis system
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3. Target objective
Cylinder: about 2 mm in diameter
and below 20 mm in length
Fully implanted system with
sensors, electronics and transmission 5
4. Challenges in implant design
Miniaturization:
Small size, low-power consumption, low-impact
Biocompatibility:
Membrane design
A set of target measurements
Molecules, pH, temperature, pressure
Reliable, highly-sensitive readout electronics
Data processing and/or transmission
Commercial feasibility is related to volume production
Platform-based design
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5. The platform and its components
Specific components
Probes and electrodes
Chambers and fluidic circuits
Electronic components
Transconductance amplifier and data conversion
Transmission and powering
Probes
Electrodes
Readout Potentiostat
Signal processing
Transmission
Powering
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6. The electrochemical sensing principles
Oxidation peak
Oxidation Potential
V
Reduction Potential
I
Reduction peak
Peak position returns the molecule signature the sample
Peak current returns the concentration of the target
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7. Electrode functionalization
A probe is a molecule reacting with a selected target
Many possibilities
Our goal is modularity and targeting proteins
Oxidases (e.g., glucose oxidase)
React with target and release H2O2
H2O2 oxidizes at a specific potential (close to 650mv) generating
current
Chronoamperometry – measure current in a time window
Cytochrome P450 (family of enzymes)
React with target(s) and generate current at specific potentials
Cyclic voltammetry– measure current while sweeping voltage
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13. Single/multiple target sensing
Extending or arraying the probes
Proximity and interference of molecules
Separate chambers and fluidics
Using probe with different redox potentials
Cyclic voltammetry
Analyze different redox peaks
Etoposide electrochemical detection
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14. Platform design challenges
Design modular platform that can be adapted to
Single/multiple targets
Parametrize components and potentiostat
Potentials must vary slowly
Watch out for drifts and noise
Transconductance amplifier
High-sensitivity, linearity, low noise
Overall low-power consumption for data acquisition,
processing and transmission
Power can be transmitted as magnetic field
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24. Conclusions
Medical implants are an important testbed for
advanced electronic and sensor design
Specific issues relate to co-design of sensors and
electronics:
New materials, nanostructuring, new circuits
Low-energy sensing and computation
Platform-based design is key to low-cost production
and to commercialization
Challenges to integration are both technical and commercial
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25. Thank you
PhD Students
1. Jacopo Olivo
2. Sara Ghoreishizadeh
3. Irene Taurino
4. EnverGürhan Kilinç
5. Giulia Siciliano
6. Roger Ulrich Scientists and Collaborators:
7. Tom Kleier 1. Thomas Burger
8. Beat Muheim 2. Michele Proietti
9. Michael Fairhead 3. Renate Reiss
10. Michael Richter 4. Thomas Ramsauer
5. Frank Gürkaynak
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Editor's Notes
It has been shown that administration of ATP at micro-molar concentrations can block tumor growth18-20. A possible application of our sensor, which is sensitive to micro-molar concentrations, is the monitoring of ATP in tumors: ensuring constant control of ATP concentration may represent a tool to personalize the anticancer therapy, helping to minimize the side effects coming from over-dosage of the compound, and to establish the optimal amount for the maximum therapeutic effect.