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Interferon History Files as of February 2020

History of Interferon

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Interferon History Files as of February 2020

  1. 1. Papers Reporting the Discovery of Interferon Proc. Royal Soc. London 147:258-267, 1957 Proc. Royal Soc. London 147:268-273, 1957
  2. 2. Dr. Alick Isaacs -1957
  3. 3. First designation of “Interferon” from Isaacs notebook
  4. 4. I N V I T A T I O N Jean Lindenmann Symposium September 27, 2004 to celebrate and honour Jean Lindenmann’s 80th Birthday We cordially invite you to attend this celebration Otto Haller Peter Staeheli Abteilung Virologie Institut für Med. Mikrobiologie und Hygiene UNIVERSITÄTSKLINIKUM FREIBURG
  5. 5. Plaque assay used to measure Interferon
  6. 6. Dr. Alick Isaacs and Dr. Sam Baron
  7. 7. Flash Gordon cartoon depicting “first” human use of Interferon circa early 1960s
  8. 8. Photo Courtesy of the National Institute for Biological Standards and Control, UK
  9. 9. From: Glasgow, L.A. Interrelationships of interferon and immunity during viral infections. J. Gen. Physiol. 56S: 212-226, 1980.
  10. 10. W.E. Stewart II, 'The Interferon System' Springer Verlag 1980
  11. 11. Nature. 1980 Mar 27;284(5754):316-20. Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. • Nagata S, Taira H, Hall A, Johnsrud L, Streuli M, Ecsodi J, Boll W, Cantell K, Weissmann C. Double-stranded cDNA prepared from the 12S fraction of poly(A) RNA from interferon (IF)-producing human leukocytes was cloned in Escherichia coli using the pBR322 vector. One of the resulting clones had a 910- base pair insert which could hybridise to IF mRNA and was responsible for the production of a polypeptide with biological IF activity. Up to 10,000 units IF activity per g of cells was obtained from some clones.
  12. 12. Copyright:Time Magazine
  13. 13. First Paper using Interferon to treat Hepatitis C
  15. 15. Original boxes Kari Cantell used to ship interferon