First designation of “Interferon” from Isaacs notebook
I N V I T A T I O N
Jean Lindenmann Symposium
September 27, 2004
to celebrate and honour
Jean Lindenmann’s 80th Birthday
We cordially invite you to attend this celebration
Otto Haller Peter Staeheli
Institut für Med. Mikrobiologie und Hygiene
Flash Gordon cartoon depicting “first” human use of Interferon circa early 1960s
Photo Courtesy of the National Institute for Biological Standards and Control, UK
From: Glasgow, L.A. Interrelationships of interferon and immunity during viral infections.
J. Gen. Physiol. 56S: 212-226, 1980.
W.E. Stewart II, 'The Interferon System' Springer Verlag 1980
Nature. 1980 Mar 27;284(5754):316-20.
Synthesis in E. coli of a polypeptide with
human leukocyte interferon activity.
• Nagata S, Taira H, Hall A, Johnsrud L, Streuli M, Ecsodi J,
Boll W, Cantell K, Weissmann C.
Double-stranded cDNA prepared from the 12S fraction
of poly(A) RNA from interferon (IF)-producing human
leukocytes was cloned in Escherichia coli using the
pBR322 vector. One of the resulting clones had a 910-
base pair insert which could hybridise to IF mRNA and
was responsible for the production of a polypeptide
with biological IF activity. Up to 10,000 units IF activity
per g of cells was obtained from some clones.