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Implmentation of TMS at BHH
Mass Spectrometry ,[object Object]
General Principles
LC ,[object Object],[object Object],[object Object],[object Object]
General Principles
Inlet (Source) ,[object Object],[object Object],[object Object]
Interface
General Principles
Ionisation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ESI ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ESI Soft ionisation technique; little fragmentation Large molecules may be protonated more than once Peaks seen for same compound with different m/z ratios
 
 
APCI ,[object Object],[object Object],[object Object]
 
General Principles
Mass Separation ,[object Object],[object Object],[object Object],[object Object]
Mass Separation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Mass Separation
General Principles
Detection ,[object Object],[object Object],[object Object],[object Object],[object Object]
Electron Multiplier
Electron Multiplier ,[object Object],[object Object],[object Object]
TMS
 
 
 
Data Acquisition Modes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Data Acquisition Modes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MRM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MRM
TMS
Compound Dependent Parameters ,[object Object],[object Object],[object Object]
Compound Dependent Parameters ,[object Object],[object Object],[object Object]
 
 
 
Source Optimization Parameters ,[object Object],[object Object],[object Object]
Source Optimization Parameters ,[object Object],[object Object],[object Object],[object Object]
Common Problems ,[object Object],[object Object],[object Object]
 
 
 
Ion Suppression ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adducts and Clusters Formed in LC-MS Cluster/Adduct Source of Cluster Occurence Mass of Cluster Ion [M + CH3COO]- Acetic Acid APCI & IS -ve mode M + 59 [M + Cl]- Chlorinated Solvent APCI & IS -ve mode M + 35 [M + NH4]+ Ammonia APCI & IS +ve mode M + 18 [M + Na]+ Sodium Salts APCI & IS +ve mode M + 23 [M+K]+ Potassium Salts APCI & IS +ve mode M + 39 [M + CH3CNH]+ Acetonitrile APCI & IS +ve mode M + 42 [M+CH3OHH]+ Methanol APCI & IS +ve mode M + 33 [M+H3O]+ Water APCI & IS +ve mode M + 19
Plans ,[object Object],[object Object],[object Object],[object Object]
 
 
 
 
Simultaneous Detection of following Drugs by LC-MS/MS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
DOA screening by LC-MS/MS ,[object Object],[object Object],[object Object]
Proposed Service for Heartlands ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
LC-MS/MS Method ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
152.1 300.2 Codeine 153 293.1   171.3 293.1 Benzoylcgonine-D3 181.2 292.2   152.1 292.2 Morphine-D6 150.1 290.1   168.1 290.1 Benzoylcgonine 198.2 290.1   154.1 290.1 Diazepam-D5 165.2 286.1   152.1 286.1 Morphine 192.9 285.1   154.1 285.1 Diazepam 180.2 282.2   236.2 282.2 Nitrazepam 249.1 278.2   234 278.2 EDDP 208.3 271.1   165.2 271.1 Nordiazepam 224.2 252.1   121.2 252.1 7-aminonitrazepam 119 150.1   91 150.1 Metamphetamine 66.9 142.2   93.1 142.2   125.1 142.2 Amphetamine-D6 119.2 136   91 136 Amphetamine Q3 Q1 Drug
Urine top std
Accuracy
 
Steroids on the LC-MS/MS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Proposed method for Steroids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Testosterone by LC-MS/MS (ESI)

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Implementation of TMS and LC-MS/MS Services at BHH

  • 2.
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  • 10.
  • 11. ESI Soft ionisation technique; little fragmentation Large molecules may be protonated more than once Peaks seen for same compound with different m/z ratios
  • 12.  
  • 13.  
  • 14.
  • 15.  
  • 17.
  • 18.
  • 21.
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  • 24. TMS
  • 25.  
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  • 30.
  • 31. MRM
  • 32. TMS
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  • 39.
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  • 41.  
  • 42.  
  • 43.  
  • 44.
  • 45. Adducts and Clusters Formed in LC-MS Cluster/Adduct Source of Cluster Occurence Mass of Cluster Ion [M + CH3COO]- Acetic Acid APCI & IS -ve mode M + 59 [M + Cl]- Chlorinated Solvent APCI & IS -ve mode M + 35 [M + NH4]+ Ammonia APCI & IS +ve mode M + 18 [M + Na]+ Sodium Salts APCI & IS +ve mode M + 23 [M+K]+ Potassium Salts APCI & IS +ve mode M + 39 [M + CH3CNH]+ Acetonitrile APCI & IS +ve mode M + 42 [M+CH3OHH]+ Methanol APCI & IS +ve mode M + 33 [M+H3O]+ Water APCI & IS +ve mode M + 19
  • 46.
  • 47.  
  • 48.  
  • 49.  
  • 50.  
  • 51.
  • 52.
  • 53.
  • 54.
  • 55. 152.1 300.2 Codeine 153 293.1   171.3 293.1 Benzoylcgonine-D3 181.2 292.2   152.1 292.2 Morphine-D6 150.1 290.1   168.1 290.1 Benzoylcgonine 198.2 290.1   154.1 290.1 Diazepam-D5 165.2 286.1   152.1 286.1 Morphine 192.9 285.1   154.1 285.1 Diazepam 180.2 282.2   236.2 282.2 Nitrazepam 249.1 278.2   234 278.2 EDDP 208.3 271.1   165.2 271.1 Nordiazepam 224.2 252.1   121.2 252.1 7-aminonitrazepam 119 150.1   91 150.1 Metamphetamine 66.9 142.2   93.1 142.2   125.1 142.2 Amphetamine-D6 119.2 136   91 136 Amphetamine Q3 Q1 Drug
  • 58.  
  • 59.
  • 60.